Anthony Jones

🧵1/6
📄 New review: Fasting reshapes the gut microbiome, boosting health! Read here: inpst.net/gut-microbio...

🌐 #Fasting #GutMicrobiota #CRBIOTECH @hipecsurvivor.bsky.social @erlangen.bsky.social @sole25.bsky.social @castltrastondrs.bsky.social @alisyngayle.bsky.social @alfredodistefano.bsky.social

Exploring the Rise of Skin-Lightening Trend Among Medical Students A study reveals the widespread use of skin-lightening products among female medical students, highlighting gaps in knowledge, practice, and the influence of social norms.

Exploring the Rise of Skin-Lightening Trend Among Medical Students
#Dermatology
www.emjreviews.com/dermatology/...

🍃 🦠 Multiple Sclerosis (MS) Risk Increased by Common Virus
🧪
Epstein-Barr virus found to be possible cause of MS in humans

science.org/doi/10.1126/science.abj8222

Exclusive: retraction-prone editors identified at megajournal PLoS ONE Nature - Study says small editor group handled many problematic manuscripts — and a Nature investigation finds out who they are.

Nearly one-third of all retracted papers at PLoS ONE can be traced back to just 45 researchers who served as editors at the journal

go.nature.com/4frnv04

Understanding Peritoneal Cancer: Treatment Options, Hope, and Hard Question

Aug. 15 Webinar:
Understanding Peritoneal Cancer:Treatment Options, Hope, and Hard Questions
#PMP
#AppendixCancer
#AbdominalCancersAlliance
events.zoom.us/ev/AvnZ-pnuo...

Health Implications of p‑Phenylenediamine: The Aromatic Amine in Permanent Hair Dye Uncover the risks and realities of a key hair dye ingredient as science, safety, and regulation collide in the quest for perfect color.

Uncover the risks and realities of a key hair dye ingredient as science, safety, and regulation collide in the quest for perfect color. www.news-medical.net/health/Healt... #PPD

Blood taken from Danish babies ended up in huge genetic study—without consent The iPsych project, which investigates the genetics of psychiatric disorders, has sent 140,000 opt-out notices amid backlash

Blood taken from Danish babies ended up in huge genetic study—without consent: The iPsych project, which investigates the genetics of psychiatric disorders, has sent 140,000 opt-out notices amid backlash | Science | AAAS www.science.org/content/arti...

‘Told Her Stage 4 Cancer Was Inoperable,’ a 38-Year-Old Therapist Defies Prognosis, Advocating for Additional Treatment—Now It’s Undetectable. Her Message: Always Seek a Second Opinion - NewsBreak A 38-year-old woman who experienced worsening stomach pain and a growing lump in her belly, but her initial doctor dismissed it—only at the ER was she told

‘Told Her Stage 4 Cancer Was Inoperable,’ a 38-Year-Old Therapist Defies Prognosis, Advocating for Additional Treatment—Now It’s Undetectable. Her Message: Always Seek a Second Opinion
#AppendixCancer
www.newsbreak.com/survivornet-...

Remembering Iconic 'Breakfast at Tiffany's' Star Audrey Hepburn— The Major Advances & New Mystery Since Appendix Cancer Took The Actress's Life The fashion and film world lost an iconic actress when Audrey Hepburn died after being diagnosed with cancer of the appendix 30 years ago.

August is Appendix Cancer Awareness month. By chance, we were reading Breakfast at Tiffany’s at our book group so I’m also remembering Audrey Hepburn who died aged 63 in 1993 of this cancer. www.survivornet.com/articles/rem...

How Does a Late Hypertension Diagnosis Impact Cardiovascular Outcomes? Find out how delayed hypertension diagnosis affects heart health—keep reading for key evidence guiding earlier intervention.

How Does a Late Hypertension Diagnosis Impact Cardiovascular Outcomes?
www.emjreviews.com/cardiology/n...

Does Acupuncture Improve Postconcussion Symptoms After Mild Traumatic Brain Injury? Learn how acupuncture offers long-term relief for postconcussion symptoms in mild traumatic brain injury.

Does Acupuncture Improve Postconcussion Symptoms After Mild Traumatic Brain Injury?
www.emjreviews.com/radiology/ne...

YouTube video by WBAL-TV 11 Baltimore Study shines light on misdiagnosed appendix cancer

Study shines light on misdiagnosed appendix cancer
#AppendixCancer
youtu.be/T2GgHKqW9WM

Mercy Medical Center study shines informs about appendix cancer Twenty years ago, appendix cancer was virtually unheard of — because many cancers were misdiagnosed.

Mercy Medical Center study shines light on why appendix cancer used to be unheard of
#HIPEC
#AppendixCancer
www.wbaltv.com/article/merc...

Pseudomyxoma Peritonei With Suspected Gastroesophageal Junction Mass: A Rare and Atypical Presentation Pseudomyxoma peritonei (PMP) is a rare clinical entity characterized by the accumulation of mucinous ascites and peritoneal implants, most commonly originating from appendiceal or ovarian neoplasms. I...

Pseudomyxoma Peritonei With Suspected Gastroesophageal Junction Mass: A Rare and Atypical Presentation
www.cureus.com/articles/391...

Here’s a structured summary of the main findings and insights from the article “A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation” published in Molecular Systems Biology: ________________________________________ 🧬 Key Findings 1. Persistent Epigenetic Changes After Mild SARS-CoV-2 Infection • Both asymptomatic and mildly symptomatic infections induce similar DNA methylation changes, even when gene expression returns to baseline. • These methylation changes persist for months, resembling patterns seen in autoimmune and inflammatory diseases. 2. Methylation Clock Model • Researchers developed a machine learning model using methylation data to: o Distinguish between pre-, during-, and post-infection states. o Accurately predict time since infection. • The methylation clock revealed distinct temporal clusters of methylation changes, each associated with specific immune cell types and transcription factors. 3. Anti-Protective Epigenetic State • Contrary to the concept of trained immunity, the post-infection methylation state was found to be anti-protective: o Individuals with a pre-infection methylation pattern resembling the post-infection state had higher viral loads and worse outcomes. o This state was not induced by BCG vaccination, suggesting it is distinct from known protective epigenetic responses. ________________________________________ 🔍 Comparative Insights 4. Overlap with Other Diseases • The post-SARS-CoV-2 methylation signature showed significant overlap with: o Systemic Lupus Erythematosus (SLE) o Chronic infections (e.g., HIV, Hepatitis C) • No significant overlap was found with asthma, allergies, or tuberculosis. 5. Age and Epigenetic Vulnerability • The post-infection-like methylation state increased with age, suggesting cumulative immune challenges may predispose individuals to less effective viral suppression. ________________________________________ 🧠 Conceptual Implications 6. Epigenetic Memory o…

Even mild or asymptomatic SARS-CoV-2 infections can leave a lasting imprint on the immune system—one that may resemble patterns seen in autoimmune diseases and chronic infections.

This challenges the assumption that recovery from mild illness is complete.
www.embopress.org/doi/full/10....

This is figure 2, which shows the effect of COVID-19 and the pandemic on brain ageing.

Rates of brain ageing accelerated during the COVID-19 pandemic, even among those who did not get infected with SARS-CoV-2, suggests a study of nearly 1,000 UK adults published in Nature Communications. go.nature.com/4lZA5Xf #medsky 🧪

Microbiota/gut/neuron axis promotes Drosophila ageing via Acetobacter, Tachykinin, and TkR99D https://www.biorxiv.org/content/10.1101/2025.07.31.667994v1

"Analyses of cancer survivors databases reveal that SARS-CoV-2 infection substantially increases the risk of cancer-related mortality and lung metastasis compared with uninfected cancer survivors."

Mice data show #COVID drives the proliferation of previously dormant cancer cells.

Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies: 9783319285689: Medicine & Health Science Books @ Amazon.com

Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies
#AppendixCancer
a.co/d/gYRougC

Here is a resource on heat and meds:

www.cdc.gov/heat-health/... Heat and Medications – Guidance for Clinicians | Heat Health | CDC

With a few more days of big heat, these cities will experience the brunt of it Widespread heat indexes of 105 or higher will cover the eastern Plains, Midwest, Mid-South and Southeast including Florida. Similar conditions are expected up the East Coast to the east of the Appalac...

If you’re sweltering, you’re not alone 🥵 A reminder that some psych meds can increase heat sensitivity, so touch base with your prescriber or pharmacist and be careful out there!

www.washingtonpost.com/weather/2025...

Bifidobacterium was not found in 25% of infants and levels were insufficient in 76%.
#microbiome
www.healio.com/news/allergy...

Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis - Communications Biology The My Baby Biome Study demonstrates that three gut microbiome community clusters exist in infants in the United States. These compositions vary on the prevalence and abundance of Bifidobacterium and ...

Widespread Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis
www.nature.com/articles/s42...
Missing beneficial bacteria in infant guts linked to rising asthma and allergy cases
medicalxpress.com/news/2025-07...
Fecal samples from participants in 48 of 50 US states

Comprehensive Analysis of Factors Associated with Treatment Delays in Asian, Native Hawaiian, and Other Pacific Islander Patients with Colorectal Cancer - Journal of Gastrointestinal Cancer Introduction Colorectal cancer (CRC) is the second most common cause of cancer death in the USA. Many modifiable factors affect prognosis, including but not limited to diet, smoking, alcohol, and time of diagnosis to initial treatment (TTT). Studies have found that patients who had a delay in surgery of greater than one month during the COVID pandemic and a TTT of greater than 31 days were at increased risk of death. The purpose of this study is to uncover the factors associated with treatment delay (surgery, systemic therapy, or radiation therapy) in patients with CRC. Method We analyzed data from patients diagnosed with CRC between 2000 and 2022 at Queen’s Medical Center in Honolulu, Hawaii. Patients initiating treatment ≥ 31 days after diagnosis were categorized as having a delayed treatment. Binary logistic regressions were used to identify predictors, adjusting for clinical and pathological factors. Result A total of 3192 patients were analyzed. 1128 (35.3%) patients experienced delayed treatment. On multivariable analysis, patients with older age demonstrated a progressively increased odds of delayed treatment, with odds ratio (OR) ranging from 1.35 (95% CI 1.02–1.79; p = 0.039) for patients aged 50–59 years to 1.81 (95% CI 1.32–2.47; p < 0.001) for those aged ≥ 80 years compared with patients under 50 years. Patients with Medicaid or being uninsured had significantly higher odds of delayed treatment compared with patients with private insurance (OR 1.54, 95% CI 1.25–1.89; p < 0.001). Stages 2 and 3 CRC were associated with lower odds of delay compared with stage 1. Tumor location was associated with delayed treatment. Compared with right-sided tumors, patients with rectal tumors (OR 3.16, 95% CI 2.56–3.90; p < 0.001) and left-sided colon cancer were significantly more likely to experience delayed treatment (OR 1.40, 95% CI 1.15–1.71; p < 0.001). Gender, race, and histopathology grading were not significantly associated with TTT ≥ 31 days. Conclusion Older age, having Medicaid or being uninsured, and having a rectal or left-sided tumor location were associated with delayed initiation of treatment in patients with colorectal cancer. Further research is needed to explore the underlying reasons for treatment delays in patients with these specific characteristics. Specific interventions, such as improving insurance access or addressing logistical challenges, may reduce time to initial treatment.

Delayed treatment linked to age and insurance status in CRC patients

by Tanariyakul M, Wannaphut C (...) Acoba J et 2 al. in J Gastrointest Cancer #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Figure. Screening and Diagnostic Algorithm for Early-Onset Gastrointestinal Cancers

Most viewed this week from JAMA: Early-onset gastrointestinal cancers are among the largest subset of early-onset cancers globally. This Review summarizes current evidence on early-onset gastrointestinal cancers.

ja.ma/4m6KfEU

#AppendixCancer

What if you could monitor and modulate your gut microbiome via your smartphone app?!
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Intense Grief Can Raise Your Risk of Death by Nearly 90% - Neuroscience News While grief is a natural part of loss, some people experience persistently high levels that can have long-term health consequences. A decade-long study in Denmark found that individuals with intense, ...

Intense Grief Can Raise Your Risk of Death by Nearly 90%
- Neuroscience News
neurosciencenews.com/intense-grie...

1/6
🍯Honey improves metabolic health, gut microbiota & inflammation! Read here: inpst.net/is-honey-a-h...

🌐 #FunctionalFood #INPST #NutritionScience @hipecsurvivor.bsky.social @gmpinglish.bsky.social @pjsgaveitaway.bsky.social @mlbinwa.bsky.social @chrisssali.bsky.social l @holyunknown.bsky.social