Jonathan G. Stine, MD MSc, FACP

🖤 With deep sorrow, we announce the passing of Prof. Dr. Jaime Bosch, President of the Baveno Cooperation.

A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure.

Rest in peace, Jaime

Celebrated 8 incredible years of Stine Lab with a team lunch today! Grateful for the hard work, discoveries, and camaraderie that made our journey so impactful. Here’s to the science, the memories, and the friendships that last far beyond the lab. #MASLD #Research

The muscle–adipose–liver axis is critical, yet underrecognized, in #MASLD.

Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis.

Its time to standardize definitions and intervene early:

link.springer.com/article/10.1...

Graphic showing assessment methods for various domains of muscle quality and function in patients with MASLD including insulin resistance, myosteatosis, sarcopenia, and frailty.

📢Great to write this review for Hep Comms with Matt Armstrong & @jonathanstinemd.bsky.social

💪We've covered everything you need to know about #Muscle & #MASLD
- Insulin resistance
- Sarcopenia
- Myosteatosis
- Impact of weight loss drugs
- Benefits of exercise

🔗 shorturl.at/aFO1Q

#LiverSky

Skeletal muscle and MASLD: Mechanistic and clinical insights : Hepatology Communications , which all converge on the liver to drive disease progression and adverse patient outcomes. This review explores the mechanistic links between skeletal muscle and MASLD, including the role of abnorma...

It was an absolute delight to contribute to this high-impact work with @tom-marjot.bsky.social and @mattarmstrong95.bsky.social in which we review all things #MASLD and #Muscle!

If you're looking for holiday weekend reading, look no further:

journals.lww.com/hepcomm/page...

@ebtapper.bsky.social

People walking, cycling, and using wheelchairs on a safa road. Text reads: “Hit that step count, or hop on your bicycle! Reclaim your health, and the health of the planet.”

Choose to walk 🚶‍♂️ or cycle 🚲 whenever possible.

It can help improve:
♥️ your heart,
😇 your mind,
🌏 and the planet.

Learn more 👉 bit.ly/43eExcc #RoadSafety #BeActive

Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease Autophagy, a highly conserved cellular degradation pathway promotes cell survival via lysosomal degradation of aberrant cellular proteins and recyclin…

New review out! 🧬 Autophagy plays a key role in #MASLD, regulating lipid metabolism, insulin sensitivity & fibrosis. But effects vary by cell type. Precision targeting is key. Great work led by Prashant Nighot and Kofi Clarke

Read here: sciencedirect.com/science/arti...

Heading to the PA State Capitol tomorrow to advocate for continued funding of PA CURE program. This is critical for advancing clinical and biomedical research in PA. This investment saves lives and is even more important given the status of federal research funding. #ResearchMatters #PublicHealth

#Exercise may protect the liver by blocking ferroptosis, a key cell death pathway in #MASLD. 🏃‍♀️🧬

New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence

pubmed.ncbi.nlm.nih.gov/40206477/

Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors.
Here’s (almost) everything we know about it
erictopol.substack.com/p/the-breakt...

Ok, I couldn't resist this trend any longer... I had to have ChatGPT make my action figure based on my bio and here is what it generated 😂 😂 😂

Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction - Nature Communications MASLD is a growing global health concern. Here, the authors define a senescent hepatocyte gene signature (SHGS), demonstrate its clinical relevance, and identify senolytic therapies that selectively e...

🚨Steatotic liver disease driven by senescent hepatocytes

🔑Senescent hepato lose key functions
🧬Defined senescent hepato gene signature
🧩Senescent hepato gene enrichment correlates w/ multi-organ dysfunction
🎯Senolytics target senescent hepato & improve damage

www.nature.com/articles/s41...

Public Statement on Supporting Science for the Benefit of All Citizens TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...

I join >1900 members of US National Academies of Science, Engineering, and Medicine signing this letter, as individuals, decrying the present thoughtless assault on science, which is against our national interests. docs.google.com/document/d/1... Our health, wealth, and security depend on science.

HHS starts layoffs of thousands of workers across its agencies Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.

How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...

Effects of a 12‐Week Mediterranean‐Type Time‐Restricted Feeding Protocol in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Controlled Trial—The ‘CHRONO‐NAFLD Project’ This study corroborates the efficacy of the Mediterranean diet (MD) in ameliorating cardiometabolic risk factors such as body weight and blood pressure in patients with MASLD and overweight/obesity. ...

And the CHRONO-NAFLD study can be read here:

onlinelibrary.wiley.com/doi/full/10....

Editorial: Chrononutrition and MASLD—Its About Time (Restricted Feeding)! Click on the article title to read more.

🔥🆙 to publish alongside my pre-doc #HannahMohrMS in
AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study

Read the full paper here: onlinelibrary.wiley.com/doi/10.1111/...

The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth Continued investment in the NIH is essential to fighting current and emerging health threats and to ensuring the U.S. remains a global leader in medical innovation.

THIS: The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth
www.amfar.org/news/how-nih...

Aerobic exercise interventions lead to MASH resolution in... : Hepatology Communications An abstract is unavailable.

The liver loves aerobic exercise

journals.lww.com/hepcomm/full... #liversky

Thanks for sharing our work!

Cause-specific mortality in 13,099 patients with metabolic dysfunction-associated steatotic liver disease in Sweden Data on cause-specific mortality in metabolic dysfunction-associated steatotic liver disease (MASLD) are limited. We aimed to determine the rate and risk of death from different causes in patients wit...

New paper from us in @jhepatology.bsky.social: www.journal-of-hepatology.eu/article/S016...
Causes of death in >13,000 persons with #MASLD - check it out #liversky. So proud of co-senior author Axel Wester and first author medical student Gabriel Issa for the work!

Proud to have been your resident! #HoyaSaxa!

Our March member spotlight is Dr. Pooja Singhal! She discusses the critical role women #GI docs play in assisting the unique needs of female patients, her involvement in the @amergastroassn.bsky.social Women in GI Workshop & more: buff.ly/dFGqZ2d

In these unprecedented dark times for American life science and medical research (no less well beyond biomedicine), my coping mechanism is to laser focus on the unremitting and remarkable daily advances, and the fervent hope these will not be slowed or interrupted.

Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day - Penn State College of Medicine Continuing Education Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day is a continuing education program of Penn State College of Medicine taking place in Hershey, Pa.

Join us for Penn State Health MASH Day on June 12th for a high-yield medical conference covering the latest in MASLD/MASH diagnosis and management. Don't miss expert insights and practical takeaways!

Register here: ce.med.psu.edu/mash/

It’s free!

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

Stand up for science rally at Lincoln Memorial.

Stand up for science rally at Lincoln Memorial.

Stand up for science rally at Lincoln Memorial.

Pretty big turnout at Stand Up for Science, talked with scientists and non-scientists who came to DC from all over.

Today is #WorldObesityDay and a good reminder that obesity is a major driver of #MASLD affecting billions worldwide.

The good news? #Lifestyle interventions work! #Exercise can reverse liver fat & improve metabolic health.

Let’s turn awareness into action! #ExerciseIsMedicine

Obesity is complex. Say no to discrimination. Stand up against bullying. End the stigma.

Today is #WorldObesityDay.

#Obesity is a complex condition and each individual faces distinct needs & challenges.

A healthier society is possible only if we prioritize community support & stand up against discrimination and stigma 🔗bit.ly/3SAcdeE

Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 No country to date has successfully curbed the rising rates of adult overweight and obesity. Without immediate and effective intervention, overweight and obesity will continue to increase globally. Pa...

"Without drastic intervention, 3·80 billion adults over
the age of 25 years will have overweight and obesity by
2050."
www.thelancet.com/journals/lan... @thelancet.bsky.social