Dodonova Group β Organisational principles and 3D architecture of archaeal chromatin
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? βοΈπ§¬π§«
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter β svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
15.10.2025 10:38 β π 6 π 5 π¬ 0 π 0
EMBLβs 2025 Kendrew alumni award recipient may know how to make fairy tales come true.
Irma Querques (@irmaquerques.bsky.social) repurposed the βSleeping Beautyβ transposon as a genetic tool for new therapeutics, particularly against cancer.
www.embl.org/news/people-...
14.10.2025 11:46 β π 20 π 5 π¬ 0 π 0
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
03.10.2025 16:06 β π 48 π 86 π¬ 0 π 3
Applications now open for our PhD studentship programme - Dunn School
Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.
Our PhD studentship programme is officially open; pass it on
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
08.09.2025 11:15 β π 21 π 20 π¬ 1 π 0
Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation.
edu.nl/h436k
If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!
08.09.2025 13:48 β π 6 π 8 π¬ 0 π 0
Excited to share our latest work, driven by my recently graduated PhD student Kaitlyn Barrack, exploring the mechanisms of bacterial dysbiosis in the CF gut - including a role for a colorectal cancer-associated genotoxin in this competition.
www.biorxiv.org/content/10.1...
@kbarrack.bsky.social
05.09.2025 12:57 β π 20 π 9 π¬ 1 π 1
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
31.08.2025 18:44 β π 134 π 58 π¬ 3 π 4
Our newest manuscript on the gut-lung axis in CF, lead by Rebecca Valls, explores sex and intestinal regional differences in response to Bacteroides. Check it out!
www.biorxiv.org/content/10.1...
28.08.2025 12:10 β π 12 π 5 π¬ 2 π 1
We are excited to be a part of a collaboration lead by Tarafder and Bharat titled "Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms" - this work has exciting implications for biofilm-targeted therapeutics.
www.biorxiv.org/content/10.1...
29.07.2025 13:08 β π 13 π 4 π¬ 1 π 1
Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms
led by @abultarafder.bsky.social
Great collaboration with @pearce-maths.bsky.social and @geiselbiofilm.bsky.social
www.biorxiv.org/cgi/content/...
29.07.2025 09:34 β π 38 π 14 π¬ 2 π 3
Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.
11.07.2025 10:22 β π 59 π 17 π¬ 1 π 0
Exciting study from @kiranrpatil.bsky.social and colleagues. Hannah Ochner from the group performed cryo FIB imaging.
Congrats!
01.07.2025 10:04 β π 16 π 5 π¬ 1 π 0
Excited to share our latest review on histone-mediated chromatin organization in prokaryotes and viruses! 𧬠@mpi-bio-fml.bsky.social
30.06.2025 09:33 β π 15 π 4 π¬ 0 π 0
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance
Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multi drug resistant tuberculosis. Clinical bedaqu...
Bedaquiline resistance driven by the MmpS5L5 efflux pump is threatening the drug regimens used to treat MDR-TB.
In our new preprint, we used structural and genetic approaches to better understand how MmpS5L5 effluxes bedaquiline and how future resistance may evolve. π§΅π½
#TBsky #MicroSky #TB
26.06.2025 10:30 β π 25 π 11 π¬ 2 π 1
Joe Greener
Excellent opportunity for a postdoc to join @jgreener64.bsky.socialβs group at the LMB.
Youβll help develop novel molecular simulation methods to optimise sequences for diverse design tasks in computational protein design.
See: www.nature.com/naturecareer...
Apply by 13 JUL
#PostdocJobs #ScienceJobs
25.06.2025 13:49 β π 6 π 4 π¬ 0 π 0
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance
Exciting paper by Adam Fountain and Lalita Ramakrishnan. Cryo-ET by @janboehning.bsky.social
Congrats!
www.biorxiv.org/content/10.1...
25.06.2025 10:59 β π 31 π 7 π¬ 1 π 0
Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi
Out in @pnas.org
Congrats @janboehning.bsky.social @abultarafder.bsky.social Miles Graham @mathieucoureuil.bsky.social
@mrclmb.bsky.social @hopitalnecker.bsky.social
www.pnas.org/doi/10.1073/...
23.06.2025 10:25 β π 57 π 18 π¬ 1 π 1
Portrait photo of Tanmay Bharat
Congratulations to @tbharat-lab.bsky.social, Group Leader in the LMBβs Structural Studies Division, who has received the Gold Medal from @embo.org for his research on prokaryotic surface molecules.
Read more here: www2.mrc-lmb.cam.ac.uk/tanmay-bhara...
#LMBNews
05.06.2025 12:07 β π 63 π 13 π¬ 3 π 1
A snapshot of the HLp tetramer (purple) wrapping ~60 bp of DNA (green).
Excited to share our new preprint on HLpβa bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1...
@mpi-bio-fml.bsky.social
12.05.2025 09:16 β π 88 π 37 π¬ 4 π 3
Latest news from Dept of Protein Evolution. This preprint reveals the first structurally detailed look at how a bacterial histone wraps DNA, offering new insights into genome organization in bacteria. Check it out: shorturl.at/GTIpA
Findings & author info in @vikramalva.bsky.social thread below.
12.05.2025 09:57 β π 9 π 6 π¬ 0 π 1
Exciting job opportunities!
Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.
More info: my.corehr.com/pls/uoxrecru...
07.05.2025 08:26 β π 27 π 25 π¬ 0 π 2
Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social
Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.
23.04.2025 14:07 β π 73 π 30 π¬ 4 π 2
The electron cryo-microscope adapted for use at liquid nitrogen temperatures within its custom-made black box.
A colder frontier in cryo-EM π§ͺπ¬
Chris Russoβs group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
23.04.2025 08:49 β π 49 π 23 π¬ 0 π 3
#MicroSky
23.04.2025 10:35 β π 11 π 3 π¬ 0 π 0
Left: The atomic model of the PS2 lattice is shown in top and side views. PS2 hexamers are repeated in the 2D sheet with a lattice constant of 176 Γ
. Each PS2 monomer is colored and labeled separately within the hexamer, which repeats throughout the lattice (with pore dimensions highlighted). The side view of the lattice shows the smooth surface facing the extracellular space and rough surface with coiled-coil segments protruding towards the MM. Top right: Interactions at the hexameric and trimeric interfaces are stabilized by both hydrophilic and hydrophobic residues. Bottom right: A cell envelope tomogram was used to overlay the cryo-EM structure of the S-layer onto the in situ S-layer tomographic density. A single slice of the tomogram is shown, with the overlayed PS2 S-layer lattice in green and the tomogram in grayscale. The S-layer (surface layer), MM (mycomembrane), IM (inner membrane), and Cytosol are labeled.
The unique #CellEnvelope of #corynebacteria: @tbharat-lab.bsky.social &co map the C. glutamicum cell surface, revealing a patchy S-layer & specific assembly of the PS2 protein, thereby informing our understanding of cell envelopes that contain #MycolicAcids @plosbiology.org π§ͺ plos.io/3Y6JNgw
23.04.2025 08:22 β π 14 π 5 π¬ 1 π 1
We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.
16.04.2025 17:25 β π 37 π 38 π¬ 0 π 1
Image processing for cryo-electron microscopy
Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, β¦
We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.
18.03.2025 19:06 β π 31 π 18 π¬ 1 π 4
Great opportunity in a fantastic lab
14.03.2025 15:49 β π 2 π 1 π¬ 0 π 0
Investigator scientist @MRC-LMB
grigoriefflab.umassmed.edu/
Staff scientist @biozentrum.unibas.ch using algorithms to look at tiny stuff inside cells, or #cryoET if you prefer. Here I talk mostly about my research. Views my own. π§π· in π¨π
Postdoc in Bharat group at MRC-LMB | structural biology enthusiast | S-layers | cryo-EM | cryo-ET | conjugative transposons
Assistant Prof and Group Leader at Max Perutz Labs, University of Vienna
Postdoc in Bharat group at MRC-LMB | cryo-EM | cryo-ET |
https://www.ucl.ac.uk/~ucahppe/
π¬π§π―π² Fellow Uni. of Edinburgh. Theoretical physicist, active and living matter, statistical physics.
Prev: INI Research Fellow Cambridge, UCL, Uni of Lux., Uni of Toronto, London Centre for Nano.
Web: www.drlukekdavis.com
Senior Lecturer Imperial College London
Microbiology Bacteriology Scientist Biofilm Bacteria Nature T6SS and bacterial competition
PI of York Bioenergetics Lab in YSBL/ Department of Chemistry, University of York. Interested in biophysical methods to explore bioenergetics and microbiology, especially in tuberculosis
lab website : bioenergetics.site
ORCID: 0000-0001-5420-2116
Elmer R. Pfefferkorn, PhD, Professor of Microbiology & Immunology at the Geisel School of Medicine, EiC of the Journal of Bacteriology; Bacterial Biofilms, Surface Sensing, c-di-GMP Signaling, Polymicrobial Communities & Gut Microbiota in Cystic Fibrosis
BBSRC NEEDL PhD student in the Salgado lab @ Newcastle University.
Working on Cell wall proteins and S-layers of C. difficile π¦ π§«π¬
PhD student in the Jakobi lab @Bionanoscience, Delft | Imaging cool things with electrons | cryo-ET
MD-PhD student at The Ohio State University. Interested in academic medicine and translational research on chronic biofilm-mediated bacterial infections.
β
PhD (2025)
π MD in progress (2027)
π Physician Scientist (forever)
(All views are my own)
Post-doc using cryoET to investigate Alzheimer's pathology at the Astbury Centre University of Leeds π§ π¬
PostDoc in the Ramakrishnan/Luisi labs at University of Cambridge.
Bedaquiline resistance in Mycobacterium tuberculosis #ENDTB
Relaying microbiology news, articles and comments relevant to aspects on bacteria, fungi, viruses and other microbes / microorganisms. Microbes are πͺ
Cryo-EM @Prof Daniel Wilson Lab, Uni of Hamburg, Germany
Single particle cryo-EM, cryo-electron tomography
#cryoem #teamtomo #volumeEM #thermofisherscientific
Yosemite is my happy place