Jonathan Pollack

We drove to Columbia and back. I have no sympathy for STL driving after I-70 terror.

Hope they enjoy WG. We've overall had a great experience here.

My $18K/mo version (I'm not paying for it) seems to be working really well, but if I can get 90% of the effect for $40...

Back when I was a C++ developer, my experience was that a lot of perl code (specifically focused around regexs) was extremely difficult to read and debug. I'm sure the same could be said about C++. Every language has its challenges to outsiders.

I've also found most LLMs highly skilled at Python.

But do they finally generate perl code that isn't write-only?

How does it stack up compared to TRF-budesonide?

Personally, at this point in my life I'd like someone who is proactive rather than reactive. An approach of wait-and-see isn't great when you've already waited and seen.

I think I saw this movie.

That's definitely been my experience, and it's awful.

My condition has stabilized over the past 6 months thanks to sparsentan and TRF-budesonide and sweeping dietary changes, but I am still Stage 3B (I was Stage 4). My PCP caught this and sent me to a nephrologist way too late.

I think if somebody has no capital, they're going to find it difficult to get a $30K 10 year loan at a good APR; 120-month amortization would be a higher rate than the typical 6-9% APR for somebody with no capital but excellent credit for an unsecured loan. Not an expert but that's my initial take.

I don't think the math maths on this, as you have to repay the loan with interest while it's invested.

Over. Always over.

Agreed. Are you managing it with meds?

Yes. I was diagnosed with IgAN in January.

You just made William of Ockham very proud.

Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy - Scientific Reports Scientific Reports - Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy

This seems like it could be important.

doi.org/10.1038/s415...

#IgAN #IgANephropathy #NephSky

I still miss the interactivity of early Twitter. Having time for that is a different question entirely.

#longfurby #furby #oilpainting

Curious how many people (doctors and patients) start doing research once they're diagnosed with a medical condition. Does my extremely deep dive as a patient with #IgANephropathy make me an outlier? #medsky #nephsky

Monthly REMS labs are tomorrow. Why do I get nervous every single blood draw? #IgANephropathy #IgAN #kidneydisease

Is this open to patients as well as practitioners?

Causal associations between environmental factors and risk of IgA nephropathy and membranous nephropathy: a bidirectional Mendelian randomization and mediation analysis - PubMed This study provides novel evidence of causal relationships between 20 genetically predicted environmental factors and the risk of IgAN and MN. These findings may inform targeted prevention strategies ...

I guess I should switch from a plant-based diet to eating copious amounts of cheese again now.

Me, too.

I've had this printed out in a clear plastic protector sitting on my desk since early this year. Great resource for patients, too.

Why didn't I get the water bottle? I got a Tarpeyo one.

This is my first-line treatment as well, and I never had any medical intervention until Filspari. UPCR dropped from 1.678 to 0.289 after about a month on sparsentan. Protein went from 99mg/dL to 11mg/dL over the same period. Just added Tarpeyo to the mix to hopefully knock IgAN into remission.

a photograph of the front cover of the Goldberg Passover Haggadah with a yellow background, black text in English and Hebrew, and a decorative border in red and black

Growing up, we used the Goldberg one and did everything in English and Hebrew.