Jonathan Pollack

Sparsentan started as first-line therapy (still on that), Tarpeyo (completed the 9-month course last month), Farxiga (started in November), and just started Voyxact last month. Proteinuria dropped to remission level with Filspari alone and is now in the normal range - amazing given the scarring.

What were you on before this?

Keep me posted on how it goes! There are a lot of nephrologists here watching!

How does it carry everything?

Update: My insurance company has now approved Filspari after an appeal and fantastic letter of medical necessity from my nephrologist's office. Pay your staff well and tip your servers!

#IgANephropathy #NephSky #IgAN

Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+β7+ cells in IgA nephropathy

doi.org/10.1016/j.kint.2025.12.026

#NephSky #MedSky #IgAN

Also enough engineering and advanced math classes that I can no longer do basic math.

CS313
CS422
CS423
CS467
CS533

Look what my friend Ian made for retro computing. So cool!

#retrocomputing

Normalize double contractions.

I'mn't = I am not
they'lln't = they will not

Ah, well it is now. Have you asked about it? I started 3 days after my last Tarpeyo dose.

No Voyxact?

I started Filspari on 1/24/2025 and was in complete remission by 3/20/2025. Hope this tracks my progression.

#IgANephropathy #IgAN #NephSky

This trial in #ASNCJASN explored the association between complete remission of proteinuria and kidney function decline during sparsentan or irbesartan treatment. Read more: kidney.pub/CJASN0961

Tell me you've thoroughly read the KDIGO guidelines without telling me you've thoroughly read the KDIGO guidelines (except they're cited in the review).

#IgANepropathy #IgAN #NephSky

Coming off corticosteroids, even targeted-release formulation budesonide, is no joke. I've lost a pound a day since my last dose on Monday - weight that I didn't even realize I had gained. Fortunately, I haven't had any withdrawal symptoms.

#IgANephropathy #IgAN #NephSky

For a while, that happened every blood draw or injection. Self-administering today also caused it. I wish I knew why. At least I've gotten better about preventing syncope. BP was 70/46. 😮

✔️ First dose of Voyxact (sibeprenlimab) self-administered
✔️ Standard vasovagal response for me
✔️ Glad I did this at my wonderful nephrologist's office

Any questions?

#NephSky #IgANephropathy #IgAN

This happens to people without ADHD as well!

Saw this yesterday, amazing!

We have a huge problem when your insurer gets to decide your medication. In my case, the medication worked so well that I no longer met the criteria for INITIATING - but stopping it would mean that I slide backward and I guess qualify again? What junk.

As excited as I am to have Voyxact approved, I'm equally frustrated that Filspari - a medication I'm ALREADY ON and have had great success with - was denied just because I switched insurance companies. What a cluster.

#IgANephropathy #NephSky #NephJC #IgAN

Is the model released or public?

Primary care physicians need better education about CKD and when to refer.

So weird, I woke up and could have sworn I heard and felt something before rolling back to bed in an anxious state. I hate earthquakes but often feel phantom quakes.

I no longer have to get up an hour before eating to take Tarpeyo (Nefecon), so naturally I still woke up an hour earlier today. Other than maybe gaining a few pounds and waking up too early, I experienced no known side effects while taking Tarpeyo. Irritability was high (normal for me).

I feel fortunate on a daily basis that the nephrologist I chose knew exactly how to diagnose and treat IgA nephropathy in 2025 (and now in 2026).

I take my first dose of Voyxact (sibeprenlimab) this week and, as always, I remain your human guinea pig. (Maybe lab rodent is a better term?)

#IgANephropathy #NephSky #NephJC #IgAN

221 cases and the tonsillectomy crew looked spotless, remitting like they had a payoff. But when progression came collecting, only three dropped in that group, not enough bodies to hang the surgery. The stats snarl, but in a non-randomized town, bias is the trigger.

doi.org/10.1093/ndt/...

This is me just about every day.