Cravedi Lab

Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model Despite much-improved protocols that broadly suppress the adaptive immune cells, most allografts are still lost to chronic rejection, in which macrophages have been prominently featured in the graft. ...

Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model - American Journal of Transplantation www.amjtransplant.org/article/S160...

Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy Membranoproliferative glomerulonephritis (MPGN) is currently stratified into complement C3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). However, classification is subject to contin...

Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy - Kidney International www.kidney-international.org/article/S008...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...

How Propensity Scores Work This Stats, STAT! animated video explores the use of propensity scores — a method of controlling for observed confounders in non-randomized studies.

How Propensity Scores Work | NEJM Evidence evidence.nejm.org/doi/full/10....

Treatment Approaches for Alport Syndrome

journals.lww.com/jasn/abstrac...

Noncanonical functions of T follicular helper cells We review the roles TFH cells play in regulating immune responses and maintaining homeostasis that extend beyond helping B cell responses.

Noncanonical functions of T follicular helper cells | Science Immunology www.science.org/doi/10.1126/...

Inhibitory immune checkpoints in cancer immunotherapy Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

Inhibitory immune checkpoints in cancer immunotherapy | Science Immunology www.science.org/doi/10.1126/...

Enzyme-converted O kidneys allow ABO-incompatible transplantation without hyperacute rejection in a human decedent model - Nature Biomedical Engineering An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

www.nature.com/articles/s41...

First human transplant of kidney modified to have ‘universal’ blood type Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.

www.nature.com/articles/d41...

The kidney slit diaphragm resembles a fishnet An essential component of the kidney filtration barrier, the slit diaphragm, is a specialized cell-cell junction composed of the cell adhesion molecules Nephrin and Neph1.

The kidney slit diaphragm resembles a fishnet - Kidney International www.kidney-international.org/article/S008...

NIH races to spend its 2025 grant money — but fewer projects win funding Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.

www.nature.com/articles/d41...

Randomized, double-blind, placebo-controlled phase 2a study assessing the efficacy and safety of felzartamab for IgA nephropathy Felzartamab is a fully human anti-CD38 monoclonal antibody under investigation for treatment of IgA nephropathy (IgAN). IGNAZ (NCT05065970) is a randomized, double blind, placebo-controlled Phase 2a s...

Randomized, double-blind, placebo-controlled phase 2a study assessing the efficacy and safety of felzartamab for IgA nephropathy - Kidney International www.kidney-international.org/article/S008...

The Truth About Organ Donation: Facts Behind the Headlines Make a difference in the field of transplantation by donating to support our cause.

In Case You Missed It!

Organ donation saves thousands of lives each year, and the system is designed to be safe and reliable. Help your community get the facts - share this article with your patients or on your social channels.

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T cells to fix a broken heart In vivo engineered T cells provide a promising approach to treat cardiac diseases

T cells to fix a broken heart | Science www.science.org/doi/10.1126/...

Normothermic Kidney Perfusion: Current Status and Future Perspectives Normothermic machine perfusion (NMP), the most recent advancement in solid organ preservation, enables ex situ maintenance of grafts in a physiologically active state, offering a significant advantage...

Normothermic Kidney Perfusion: Current Status and Future Perspectives - Kidney International Reports www.kireports.org/article/S246...

🔥 New episode of the Night Science Podcast with Akiko Iwasaki @virusesimmunity.bsky.social Yale & HHMI professor, and one of Time Magazine’s 100 most influential people in 2024! Akiko explains how leading large collaborations requires managing expectations, not micromanaging the research.

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | NEJM In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi...

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | New England Journal of Medicine www.nejm.org/doi/full/10....

Exosome-primed T cell immunity is facilitated by complement activation Extracellular vesicles (EVs) contain proteins, lipids, and nucleic acids from their cells of origin. By delivering these cargo to distant acceptor cells, EVs modulate many biologic processes, includin...

Exosome-primed T cell immunity is facilitated by complement activation - American Journal of Transplantation www.amjtransplant.org/article/S160...

Implications of the New NIH Policy on Animal Research for Transplant Science

Implications of the New NIH Policy on Animal Research for Transplant Science

www.sciencedirect.com/science/arti...

The impact of the Banff v-lesion on rejection classification and outcomes: Insights from a multicenter study According to the Banff classification, intimal arteritis (v-lesion) contributes to diagnosing T cell–mediated rejection (TCMR) and antibody-mediated rejection (AMR) and signifies more severe TCMR. Thi...

The impact of the Banff v-lesion on rejection classification and outcomes: Insights from a multicenter study - American Journal of Transplantation www.amjtransplant.org/article/S160...

Your risk of dying from chronic disease has dropped — if you live in these countries A report finds that death rates from cancer and heart disease have declined since 2010 in roughly 150 countries.

www.nature.com/articles/d41...

White text on a dark green card reads: "For the First Time, More Children Are Obese Than Underweight. One in 10 children worldwide now has obesity, a report from UNICEF found, and the number of overweight children has more than doubled in low- and middle-income countries since 2000."

For the first time, children with obesity outnumber those who are underweight across the globe, according to a new report on child nutrition from UNICEF. nyti.ms/4gE3e8x

Mouse orthotopic liver transplantation: Challenges, achievements, and applications The surgically challenging mouse orthotopic liver transplant model has provided numerous insights into liver immunobiology, cellular and molecular regulation of liver transplant ischemia-reperfusion i...

Mouse orthotopic liver transplantation: Challenges, achievements, and applications - American Journal of Transplantation
www.amjtransplant.org/article/S160...

2025 Report of the STAR Working Group on Donor Derived Cell Free DNA: Establishing Analytical Validity as the Basis for Appropriate and Effective Clinical Utilization - American Journal of Transplantation www.amjtransplant.org/article/S160...

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

What do clinical trials teach us about the pathophysiology of human IgA nephropathy? Abstract. Immunoglobulin A nephropathy (IgAN) is a primary glomerulonephritis characterized by IgA-dominant or co-dominant mesangial immune deposits seen o

What do clinical trials teach us about the pathophysiology of human IgA nephropathy? url: academic.oup.com/ndt/article/...

Albuminuria-based universal screening for CKD should be implemented now in high-income countries Chronic kidney disease (CKD) refers to altered kidney structure or function for >3 months with implications for health.1 Low glomerular filtration rate (GFR <60 ml/min per 1.73 m2) or high urinary alb...

Albuminuria-based universal screening for CKD should be implemented now in high-income countries - Kidney International www.kidney-international.org/article/S008...

EPO and tumor growth: the key is immunosuppression Erythropoietin (EPO) is an essential growth factor for erythroid progenitor cells, produced by specialized cells in the liver and kidneys in an oxygen-dependent manner. This establishes a negative fee...

EPO and tumor growth: the key is immunosuppression - Kidney International
www.kidney-international.org/article/S008...

PD-L1 on ex-vivo Expanded Toll-like-receptor-Bregs Prevents Allograft Rejection by Breg Viability Promotion, CD4+T Effector Cell Suppression, and Tregs Induction Achieving immune tolerance is a key goal in organ transplantation, as it eliminates the need for long-term immunosuppression. Regulatory B cells (Bregs) present a promising strategy for inducing toler...

PD-L1 on ex-vivo Expanded Toll-like-receptor-Bregs Prevents Allograft Rejection by Breg Viability Promotion, CD4+T Effector Cell Suppression, and Tregs Induction - American Journal of Transplantation www.amjtransplant.org/article/S160...

Leukocyte immunoglobulin like receptor B3 (LILRB3) and allograft survival: can precision medicine target health disparities? African American transplant recipients have an almost 2-fold relative risk of graft loss 5 years after kidney transplantation compared with White individuals.1 The etiology of these disparities is tho...

Leukocyte immunoglobulin like receptor B3 (LILRB3) and allograft survival: can precision medicine target health disparities? - Kidney International www.kidney-international.org/article/S008...