Richard Marcotte

Program Head – Developmental, Stem Cell, and Cancer Biology - Toronto (Region), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 673968 Provide leadership and mentorship to members of the Developmental, Stem Cell & Cancer and influence the scientific direction of the Research Institute

Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social).

jobs.sciencecareers.org/job/673968/p...

Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...

The $20 Million Bet on CRISPR to Cure Rare Childhood Diseases The center will bring custom gene-editing treatments to children.

More on the new Center
time.com/7300257/cent...

Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...

Assistant Professor (Research), Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research (C1-250514) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Canada Excellence Research Chair (CERC) in RNA Neurotherapeutics Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at…

🚨 @healthsciences.mcgill.ca‬ is recruiting: Canada Excellence Research Chair in #RNA Neurotherapeutics

Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry.

✍ Apply by July 4:

Canadian Excellence Research Chair (CERC) in Human Immunology Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Canadian Women in STEM @CDNWomenSTEM Our overarching goal is to contribute to the design and development of a national strategy for equity, diversity and inclusion in Canada. Our network is representative of female and women Canadian sci...

Good time to join us at Canadian Women in STEM.

💡Did you know that Women are significantly underrepresented in senior academic and leadership positions, such as department chairs, deans, and presidents.

Let's be the change makers. #LeadByLifting

docs.google.com/forms/d/17U2...

Director of The Neuro (Montreal Neurological Institute-Hospital) - A joint position Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Who wants to be my new chair?

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Assistant or associate professor-researcher in Neuroscience related to neurological disorders and/or neural regeneration and precision health Description  The Neuroscience Research Axis of the CRCHUM and the Department of Neuroscience of the UdeM are inviting applications for a position of assistant or associate professor-researcher in neur...

Call for an Assistant / Associate Prof. just opened at the @crchum.bsky.social in the Neuroscience Axis !

www.chumontreal.qc.ca/en/emplois/a...

Une avancée prometteuse pour améliorer l’efficacité et la sécurité de certaines chimiothérapies! Publiés dans la prestigieuse revue scientifique PNAS, de récents travaux de l’équipe de recherche du Dr Javier Di Noia, directeur de l’Unité de recherche en biologie moléculaire des cellules B à l’IRCM, montrent quel rôle crucial pourrait jouer l'enzyme CDADC1 dans l’efficacité et la sécurité de certains traitements anticancéreux. 🔎En savoir plus: Lien nouvelle

Une avancée prometteuse pour améliorer l’efficacité et la sécurité de certaines chimiothérapies!
L’équipe du Dr Javier Di Noia (IRCM) met en lumière le rôle crucial que pourrait jouer l'enzyme CDADC1 dans l’efficacité et la sécurité de certains traitements anticancéreux.
🔗 bit.ly/4e1TyDm

Translational control of leukemic metabolism and disease progression Acute myeloid leukemia (AML) is an aggressive hematological cancer with a 70% five-year mortality rate. Relapse occurs in approximately half of adults treated with intensive chemotherapy, while responses to targeted therapies are short-lasting. Frequent mutations in signaling pathways, such as FLT3 tyrosine kinase and RAS, lead to dysregulated mammalian target of rapamycin complex 1 (mTORC1)and mitogen-activated protein kinase (MAPK) signaling, increased protein synthesis, enhanced mitochondrial fitness, and metabolic adaptations that drive leukemic cell proliferation and survival. Here, emerging evidence supporting the unique role of eukaryotic initiation factor 4F as a key driver of the expression of proteins regulating leukemic cell metabolism and survival and the potential therapeutic benefit of targeting this pathway pharmacologically in AML are discussed.

Translational control of leukemic metabolism and disease progression

Strongest possible endorsement for getting in touch with Jesse (and the Department of Microbiology & Immunology at McGill and the wonderful city of Montréal). And I also endorse escaping to Canada. 🇨🇦🇨🇦🇨🇦

Personalized gene editing saved a baby, but the tech’s future is uncertain The personalized CRISPR treatment could be the future of gene therapy, but hurdles remain before everyone has access.

Costs, government regulation and lack of know-how could hinder wider use of the CRISPR tech.

Exact, et le coût prohibitif (>$2M) rend l'accès assez difficile....

Pour certaine anémie falciforme, il y a déjà une thérapie approuvée utilisant la technologie CRISPR, Casgevy.

Thérapie génique | Première mondiale au CHU Sainte-Justine Un jeune homme de 18 ans est essentiellement « guéri » après être devenu le premier patient jamais traité avec une technologie ultra-sophistiquée d’édition génique, dans le cadre d’un essai clinique i...

L'un de mes anciens collaborateurs (Elie Haddad) vient de procéder à une première mondiale en modifiant génétiquement les cellules dysfonctionnelles de la moelle osseuse d'un jeune patient pour lui réinjecter une fois réparées, et ainsi le guérir.

C'est vraiment extraordinaire!

A multi-kingdom genetic barcoding system for precise clone isolation - Nature Biotechnology A barcoded CRISPR base editing system isolates target clones from complex mammalian, yeast and bacterial populations.

CloneSelect published in Nature Biotechnology
@natbiotech.nature.com. This retrospective clone isolation method using CRISPR base editors is a powerful tool in broad biology. A history of Soh in the Yachie lab. www.nature.com/articles/s41...

KJ Muldoon, a 9½-month-old boy with a rare condition, made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases.

Read more: nyti.ms/44H77pg

The patient, KJ, reaching out after infusion of the CRISPR therapy, with a big smile! Photo credit Children's Hospital of Philadelphia

In a medical breakthrough, a team including IGI’s
@urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months.

Read more: ow.ly/G0Bg50VTonC

#RareDisease 🧬

1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases

In new work @arcinstitute.org, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

The CERC opportunity Explore Dalhousie’s online community hub—your go-to resource for connections, opportunities, and support available at Dal. Stay informed and engaged.

Canada Excellence Research Chair opportunity to recruit top international scientists to Canada.
Come join us in Nova Scotia at Dalhousie University !
Reach out if you have questions.
www.dal.ca/research-and...
@dalhousie.bsky.social

Photo of University College on Western's London ON campus. Western University Logo. Text: "Canada Excellence Research Chairs"

Join #WesternU as our next Canada Excellence Research Chair ( #CERC). The awards provide for international researchers to lead prestigious research programs at Western and contribute to Canada's excellence in research & innovation.

Application review begins June 4, 2025.

www.uwo.ca/research/cer...

These boxes are not moving. A mind-bending optical illusion by Japanese artist Jagarikin.

SCWIST - Advocating for Diversity in STEM Are you a...

I just became a paying member of the Society for Canadian Women in Science and Technology (SCWIST @scwist.ca). You should, too, guys: they will gladly take your money to support many great activities. (All levels of membership are encouraged, but more is better :-) 🧪
⬇️
scwist.ca

🚨 Only a few days left to register for the 2025 #MRMSymposium - May 27 at the MUHC!
🎤 Keynote: @saravasconcelos.bsky.social
🌟 Talks by Joseph C. Wu, Irah King, Maryam Tabrizian — and incredible trainee presentations!
🗓️ Register by May 6!
🔗 mrm.research.mcgill.ca/event/2025-m...
#RegenerativeMedicine

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...