Richard Maguire

Biomechanics influence morphogenesis of the lung. Really cool paper by Shelby and Victor at UT Southwestern and UTD!

Are some GLP-1 medicines more cardioprotective than others? #easd25 A new real world study using US Medicare data www.novonordisk.com/content/nnco...

A robustly rooted tree of eukaryotes reveals their excavate ancestry - Nature The root of the eukaryote Tree of Life is estimated from a new, larger dataset of mitochondrial proteins including all known eukaryotic supergroups, showing it lies between two multi-supergroup assemb...

I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt

Fantastic city, excellent university.
Apply!

An ascidian egg dividing - as seen with fluorescent LifeAct protein (labels actin). The cleavage ring becoming smaller. Thanks to the Ascidian BioCell Team at LBDV

Happy New Year! I hope 2025 is good for you all. We start this year with a somewhat controversial review. www.sciencedirect.com/science/arti.... Here, we discuss how a cell receives signalling receptors from neighbouring cells, allowing the receivers to transduce a previously unknown signal. 1/3

The lives of cells, recorded - Nature Reviews Genetics Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...

"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...

Context is everything How the brain processes concepts is influenced by contextual information, such as what a person is seeing, suggests new study.

Context is everything: How context influences the way the brain processes concepts.

How to read a scientific paper @science.org

"Nothing makes you feel stupid quite like reading a scientific journal article."

Open Access
www.science.org/content/arti...

A microRNA is the effector gene of a classic evolutionary hotspot locus In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...

This is such a cool example (and one of the most convincing I've seen) of non-coding RNAs having powerful and direct control over phenotype (melanization)! 🦋

Three spidermen "statistics", "machine learning" and "AI" pointing to each other

All the time

*cough* 1079 roadworks *cough*

None today thankfully - but when they pop up, hoo boy. The rolling road works last year burying the electric cable that advanced ~ 1M a day for 6 months? Ooof. 😩

File on 4 - The International Student Scandal - BBC Sounds Are UK universities ignoring poor English language skills to attract overseas students?

This episode hits the nail on its head. It failed to mention the negative impact on research capacity & that unis are held back from educating talent to raise UK's competitiveness. The lady calling lecturers lazy should apologise. I would love to compare our workloads! www.bbc.co.uk/sounds/play/...

What is ageing? Even the field’s researchers can’t agree Survey of scientists who study ageing finds no consensus on the fundamentals.

"Researchers studying ageing disagree on just about everything — including what ageing is, whether it is a disease and when it starts — according to a survey of about 100 scientists working in the field."
by @smritimallapaty.bsky.social in Nature.
www.nature.com/articles/d41...

I've been having a lot of fun with this (ongoing) project with my colleagues @zunlongke.bsky.social and @danleahy.bsky.social, who have both just joined bluesky. 1/4

Such cool structures of signaling receptors here!

It's made it. I had the first "mm, maybe I need to uninstall the app so I can get on with work" thought today!

Cool starter packs 8 & 9! by @aineurolab.bsky.social , Dev Bio I & II:
bsky.app/starter-pack...

bsky.app/starter-pack...

I merged these into a single list: bsky.app/profile/drma... using this excellent tool: nws-bot.us/bskyStarterP...
There doesn't seem to be a limit & I can use them as feeds!

University of Hull to close its chemistry department - BBC News The university is also merging some of its schools following a drop in student numbers.

A concerning #trend in #basicsciences🧪: Following a drop in student numbers, the University of Hull is closing its Chemistry Department because courses are “not financially nor educationally sustainable” 😳🤔

#education #academic #stem #highereducation

www.bbc.com/news/article...

For our very first #FluorescenceFriday on #BlueSky, let's go back to arguably the most fundamental process of development: mitosis. I just never get tired of watching the chromosomes dance. Sample: ectodermal cells, nuclei: H2B-mCherry, plasma membrane: RFP-CAAX.

Figure 1 (A) Larval expression of vegfc:EGFP (green) and kdrl:DsRed (magenta) lines in a 2 dpf live fish. Scale bar: 200 µm. (B) Confocal images showing vegfc:EGFP (green) and kdrl:DsRed (magenta) expression in the trunk at 2 dpf. A single-channel image of vegfc:EGFP expression is shown in grayscale on the right. Scale bar: 100 µm. (C,D) Whole-mount images (maximum projections of z-stacks) of the ventricular surface showing expression of vegfc:EGFP (green) and flt1:tdTomato (magenta) at 5 wpf (C) or 8-9 wpf (D). Single-channel images of vegfc:EGFP expression are shown in grayscale on the right. The framed regions are enlarged beneath. The arrows indicate EGFP+tdTpmato+ arteries. Scale bars: 100 µm.

Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration

Read this Research Article by Sierra Duca, Yu Xia, Michael R. M. Harrison, Jingli Cao and colleagues:
https://buff.ly/49hhwIf

Happy #FluorescenceFriday!

Right??? There was a great paper from Rachel Green's lab on this too. doi.org/10.1016/j.ce...

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo Solar UVB light causes damage to the outermost layer of skin. This insult induces rapid local responses, such as dermal inflammation, keratinocyte cel…

sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

Really excited to launch the megabouts.ai project from @adrienjouary.bsky.social. The era of large-scale behavioral data brings with it the challenge of how to integrate and compare data acquired using diverse set-ups and tracking approaches. (1/n)

So far I tend to agree with this. Bluesky's corporate aims and goals are different than the user expectation for it, and no one company will make 23 million users 100% happy 100% of the time. But they've been good at communication and in giving users tools to create their own space. Tricky stuff.

Mitosis in a green alga. The cell grows until it is tetralogy, then divides twice to form 4 new haploid cells. This is one of my study algae, Oophila amblystomatis, a symbiotic green alga. #protistsonsky #protistaday

rich gold-yellow moth and rose-pink moth sitting on a sheet

Good morning, please have a nice bug*.
#invertebrates #BugADay

*Rosy maple moth

On the origin of mitosis-derived human embryo aneuploidy Nature Communications - Chromosome segregation errors are common in the early stages of human embryonic development. By examining the first mitotic divisions of human embryos using live cell...

Chromosome segregation errors are common in the early stages of human embryonic development. Read here our open access commentary on three recent studies of spindle architecture and positioning features that
could provide insights into why early embryos are predisposed to aneuploidy.
rdcu.be/d1TgG