preLights

New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos.
www.biorxiv.org/content/10.6...

Kosmos: An AI Scientist for Autonomous Discovery - preLights Helping researchers from start to finish. Kosmos aids the research workflow by reading the literature, proposing hypotheses, generating and running analyses, and producing traceable, reproducible repo...

Discussing #arXiv preprint 'Kosmos: An AI Scientist for Autonomous Discovery' 🤖

Manuel Lessi & @ramadio.bsky.social share their excitement and worries + discuss possible uses of Kosmos. Includes a lovely graphic created by Theodora M Stougiannou

#preLight⬇️
prelights.biologists.com/highlights/k...

Our new preprint is live!🎉
Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions.

On bioRxiv now!

Congrats @dyuthisreekumar.bsky.social

www.biorxiv.org/content/10.6...

Figure from: 3D-super-enhancers are condensate-associated cis-regulatory communities

A new algorithm called BOUQUET maps which genes interact with transcriptional condensates by integrating 3D genome topology and protein binding data. The approach identifies "3D-super-enhancers"—exceptionally protein-rich regulatory...

https://www.biorxiv.org/content/10.1101/2024.02.01.578210

Delighted to speak with @reinierprosee.bsky.social @prelights.bsky.social about the work that we do at the Journal of Emerging Investigators. Check it out here!

Image shows part of a preLights post highlighting a preprint titled ‘Evolution of taste processing shifts dietary preference’. In a dark-grey box, you see a summary written by T. W. Schwanitz: “Flies learning to like 'vomit fruit': an example of bitter going from 'yuck' to 'yum'. New research in Drosophila sechellia reveals how taste circuits can evolve to make bitter better”. In a blue box below, you see the postLight Timothy recently added comparing the preprint with the published paper now published in Nature.

Excellent postLight uploaded by Timothy Schwanitz!

He revisits work @enriberti.bsky.social & team revealing how taste circuits in Drosophila sechellia can evolve to make bitter better; originally posted as preprint, now published in @nature.com

#postLight: prelights.biologists.com/highlights/e...

Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]

New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️
www.biorxiv.org/content/10.1...

Structural model is already available in the PDB (9MLC).

Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.

🔗 www.biorxiv.org/content/10.6...

New preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social

arxiv.org/abs/2601.20483

Friends! I am so happy to share our new preprint!

Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.

How do animals like C. elegans sense it fast and escape?

www.biorxiv.org/content/10.6...

Thread 1/

Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)

🔗 biorxiv.org/content/10.6...

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation - preLights The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.

The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted.

Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social

Check out the #preLight ⬇️👀
prelights.biologists.com/highlights/t...

In preprints: shedding light – chemogenetic induction of menstruation in mice

Aishwarya V. Bhurke and Ripla Arora from @aroralab.bsky.social discuss the recent preprint by @cagricevrim.bsky.social, @karalmckinley.bsky.social and colleagues on the X-mens menstruation model.

doi.org/10.1242/dev....

Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social

www.biorxiv.org/content/10.6...

A new extreme of meiotic evolution:

✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility

Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.

more about it:
www.biorxiv.org/content/10.6...

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton - preLights The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin.

The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin. 🪄🎩

Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint

#preLight ⬇️
prelights.biologists.com/highlights/a...

Nine subcortical/cerebellar atlases included in the subcortex_visualization Python package (and subcortexVisualizationR package in R). The atlases are depicted in two-dimensional vector graphic format.

The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)!

Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...

Our latest preprint on how regional cellular, molecular, and other forms of heterogeneity shape macroscopic wave dynamics is now out:
www.biorxiv.org/content/10.6...

For a full thread, see:
x.com/_victorbarne...

Morphological variations in external genitalia do not explain the interspecific reproductive isolation in Nasonia species complex (Hymenoptera: Pteromalidae) - preLights Isolation mechanisms that prevent mating between different species of parasitoid Nasonia wasps remain a mystery

preLighter Stefan Friedrich Wirth covers a #preprint from Dr Raychoudhury & team #DBS_IISERM

It concludes that the isolation mechanisms preventing mating between different species of parasitoid Nasonia wasps remain a mystery 🔮 #zoology #evolution

#preLight⬇️
prelights.biologists.com/highlights/m...

Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate - preLights A deep dive into how transcription factors shape radial glia fate and clonal dynamics

10/ Thanks to Manuel Lessi for highlighting a preprint of the study prelights.biologists.com/highlights/d...

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

Kanishka Parashar #UNIL has uploaded a #postLight. 👀

Here, Kanishka revisits work from @matteoall.bsky.social & team originally posted as a #preprint, highlighted as a #preLight and now published in @jcellsci.bsky.social

#postLight ⬇️👀
prelights.biologists.com/highlights/p...

A Novel Chimeric Antigen Receptor (CAR) - Strategy to Target EGFRVIII-Mutated Glioblastoma Cells via Macrophages - preLights Outsmarting Brain Tumors with Engineered Immune Cells: ''CAR‑Macrophages on the Frontline”

Outsmarting brain tumours with engineered immune cells.

Dina Kabbara highlights a #preprint in which Ali Turhan & team show that CAR-macrophages can be engineered 🧬 to fight glioblastoma cells while sparing healthy cells! #oncology

Check out the #preLight👇
prelights.biologists.com/highlights/a...

Human pluripotent stem cell-derived macrophages modify development of human kidney organoids - preLights Immune cells for nephron development; tweaking the organoid recipe! In the preprint highlighted here, the authors use human PSC-derived organoids to evaluate the contribution of macrophages to kidney ...

Immune cells for nephron development; tweaking the organoid recipe!

Theodora mixes science writing & visuals to highlight recent work from Filipa Lopes, Susan Kimber & team #FBMH_UoM #preprint #DevBio

Check out the #preLight + author response ⬇️👀
prelights.biologists.com/highlights/h...

I’m back here to share our new pre-print! 🔬 🧬 😃

Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia

Flow cytometry+Imaging+RNA-seq+Proteomics

Preprint available on bioRxiv [link in comments]

A Marchantia gemmaling producing ectopic vegetative propagules

Happy to share the pre-print on GEMMIFER, a novel ERF required for the initiation of gemma in Marchantia. One of the coolest phenotypes that I have ever seen. Congratulations to Yuki and Go, who led this research. #PlantScience @biorxiv-plants.bsky.social www.biorxiv.org/content/10.6...

Trade-offs between surviving and thriving: A careful balance of physiological limitations and reproductive effort under thermal stress - preLights "I would risk over-heating just to be with you" - Male red-sided garter snake

"I would risk over-heating just to be with you" - Male red-sided garter snake🔥🐍

Tshepiso Majelantle highlights recent work on thermoregulatory behaviour. #preprint #zoology

Includes an insightful response from @drhubert.bsky.social #OregonState

#preLight ⬇️
prelights.biologists.com/highlights/t...

Today in #JournalClub we discussed a new preprint that uses in situ cryo-ET and molecular dynamics simulations to study biomolecular condensate formation. Very beautiful data and interesting insights. Check it out!
www.biorxiv.org/content/10.6...