preLights

Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells - preLights ILC2—traditionally recognized for mediating anti-parasite responses—orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines

ILC2 orchestrates the immune defense against intestinal infections through the secretion of type 2 cytokines #immunology

André Luiz Amorim Costa discusses preprinted work from Rita Berkachy & colleagues now published in PLOS Pathogens. #postLight

#preLight⬇️
prelights.biologists.com/highlights/c...

Post-translational Tuning of Human Cortical Progenitor Neuronal Output - preLights On post-translational modifications and their contribution to help shape human cortical development

On post-translational modifications & their contribution to help shape human cortical development 🧠

Jawdat Sandakly covers a recent #preprint from Julien Pigeon and colleagues @hassanbraindevlab.bsky.social. #DevBio #Neuroscience

Read the #preLight ⬇️👀
prelights.biologists.com/highlights/p...

Gut microbial composition modulates food-specific CD4+ T cells in food allergy - preLights When gut microbes and CD4+ T cells go from chill to allergic drama queens

When gut microbes and CD4+ T cells go from chill to allergic drama queens 💥

Mitchell Sarmie teamed up with Serena Restori to highlight recent work from Alexa Weingarden & colleagues. #preprint #immunology

Check out the #preLight ⬇️
prelights.biologists.com/highlights/g...

the left and QR code to the right. Portrait of Grace Lim to the left, text to the right 100 extraordinary biologists Grace Lim Grace Lim is a prolific preLighter, contributor to the Node and a Development author. As a Senior Scientist at A*STAR in Singapore, Grace is leading innovative research at the frontier of stem cell biology through her discoveries on novel gastric cancer stem cell markers for targeted therapeutics. #100biologists #biologists100

Our next extraordinary biologist is Grace Lim, a prolific preLighter @prelights.bsky.social and a contributor to @the-node.bsky.social and @dev-journal.bsky.social. #100biologists

ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion - preLights GV101 will, GV101 will ROCK you!

GV101 will, GV101 will ROCK you!

Collaborative #preprint from David Herrmann & team
@garvaninstitute.bsky.social describes the impact of a ROCK2-specific inhibitor on both stromal & epithelial cells in the context of triple-negative breast cancer.
#preLight by Sharvari Pitke ⬇️

Creativity and Science Communication - the Node Science communication isn’t just about podcasts or fairs—it’s about making research relatable. Jargon and narrow topics can create barriers, so the challenge is to blend scientific language with every...

After his wonderful webinar on ‘Creativity and Science Communication’ for the Node, Anatolii Kozlov @anatoliikozlov.bsky.social shares his thoughts on the process of sharing your science in a way that is unique to you.

Check it out ⤵️: thenode.biologists.com/creativity-a...

#scicomm #creativity

Aspartate transaminases are required for blood development - preLights Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis.

Not aspartate production or redox control, but a secret third thing: Aspartate transaminases may be important for epigenetic regulation during erythropoiesis🩸

Hannah Pletcher covers work from Narges Pourmandi &colleagues @lyssiotislab.bsky.social
#preLight⬇️
prelights.biologists.com/highlights/a...

Actin Counters Geometry to Guide Plant Cell Division - preLights When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning

When geometry isn’t enough, actin helps plant cells decide where to divide, ensuring robust tissue patterning. 🌱 #PlantBiology

Goldy & team uncover a central role for F-actin as a cortical landmark.

#preLight by Jeny Jose @umeaplantsciencecentre.se ⬇️ 👀
prelights.biologists.com/highlights/a...

Preprints by preLighters: Hala Taha - preLights Every research paper carries a story—one that rarely makes it into the methods or the discussion section. Mine begins in a small parasitology lab in Sudan, on the last day before the war forced me to ...

Hala also shares the heartbreaking, courageous story behind her own #preprint now available on #medRxiv

“Every research paper carries a story...Mine begins in a small parasitology lab in Sudan, on the last day before the war forced me to flee.”

Read on: prelights.biologists.com/news/preprin...

Schistosoma haematobium DNA and Eggs in the Urine Sample of School-Age Children (SAC) in South-West Nigeria - preLights Schistosoma haematobium DNA & eggs detected in urine of school-aged children in SW Nigeria. Findings underscore the urgent need for improved diagnostics & interventions in endemic regions.

The challenge of diagnosing Schistosoma haematobium infections in school-aged children in SW Nigeria

@halataha.bsky.social highlights important work underscoring the urgent need for improved diagnostics & interventions in endemic regions #preprint
#preLight⬇️
prelights.biologists.com/highlights/s...

In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis - preLights Battling the TB blues: a pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala and colleagues to characterise the activity of TBAJ-587 and its metabolites

Battling the TB blues...😷

A pharmacokinetic-pharmacodynamic approach by Aguilar-Ayala & colleagues #IMI_ERA4TB to characterise the activity of TBAJ-587 and its metabolites. #preprint #pharmacology

Latest #preLight from @goh-zhanghe.bsky.social ⬇️👀
prelights.biologists.com/highlights/i...

Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation - preLights Exposing hydrophilic residues pushes misfolded ER proteins towards degradation.

Exposing hydrophilic residues pushes misfolded ER proteins towards degradation. 🗑️

Ana Sanchez-Molina: “…this study reshapes our understanding of protein quality control…” #preprint from Rudolf Pisa & Tom A. Rapoport #HarvardMed

#preLight ⬇️ 👀
prelights.biologists.com/highlights/l...

Maturation of the glymphatic system confers innate resistance of the brain to Zika virus infection - preLights The necessary wait – How an immature glymphatic system fails to suppress Zika virus infection in the brain

How an immature glymphatic system fails to suppress #Zika virus infection in the brain 🧠

Jimeng Li highlights work from Jhulimar Guilherme Doerl & colleagues #ufrnbr #preprint

Check out the #preLight! ⬇️ 👀
prelights.biologists.com/highlights/m...

Separation of the Early gastrula into oral and aboral halves shows that some neural cell tupes derive from aboral ectoderm, and others from i-cells

Drawing together findings from several projects over many years, we make a case that neural cell types in the Clytia larva have two embryological origins: i-cells and ectodermal.
bioRxiv 2025.11.17.688882; doi: doi.org/10.1101/2025...

VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity - preLights Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism.

On how Vangl2 shapes the heart❤️

Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism. #preprint from the team of @meilhacsigolene.bsky.social

#preLight by @prakash-patterns.bsky.social⬇️
prelights.biologists.com/highlights/v...

HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.

Reliable actin labelling in expansion #microscopy 🔬

Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social

Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...

Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate - preLights A deep dive into how transcription factors shape radial glia fate and clonal dynamics

A deep dive into how transcription factors shape radial glia fate and clonal dynamics.

Manuel Lessi: this work “combines the strengths of primary cultures and pooled CRISPRi perturbation”. #preprint Jingwen Ding & team @brainevodevo.bsky.social

#preLight ⬇️
prelights.biologists.com/highlights/d...

Getting a head start: Craniofacial heterochrony in marsupials involves dynamic changes to molecular and cellular mechanisms underlying neural crest development - preLights Those who migrate together, develop together: Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures, providing a potential mechanism that promotes acce...

Those who migrate together, develop together.

Marsupial cranial neural crest cells migrate as epithelial-like sheets to form craniofacial structures. #preprint from Axel Newton & team #PaskLab #DevBio

#prelight by Heather Pollington ⬇️👀
prelights.biologists.com/highlights/g...

Human single-cell atlas analysis reveals heterogeneous endothelial signaling - preLights How do endothelial cells differ across tissues? A new single-cell atlas of over 3 million cells shows how microenvironmental signals shape endothelial diversity.

How do endothelial cells differ across tissues?

🗺️ A new single-cell atlas of over 3 million cells shows how microenvironmental signals shape endothelial diversity. #preprint from Kaifu Chen & team

#preLight by Charis Qi ⬇️👀
prelights.biologists.com/highlights/h...

Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity - preLights By blurring the line between venom and digestion, Uloboridae spiders remind us that evolution doesn’t discard complexity — it reshapes it.

2️⃣ By blurring the line between venom and digestion, Uloboridae spiders remind us that evolution doesn’t discard complexity — it reshapes it.

#preLight + #postLight by Daniel Fernando Reyes Enríquez ⬇️👀
prelights.biologists.com/highlights/b...

Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal - preLights This research uncovers how tinkering with a basic energy pathway in cells can unexpectedly switch off key immune signals—pointing to new ways of controlling inflammation and even cancer.

Another two preLights resulting from the preprint review initiative led by Marcus Oliveira #UFRJ #Brazil

1️⃣ How tinkering with a basic energy pathway in cells can unexpectedly switch off key immune signals.

#preLight by Yan Aveiro dos Reis ⬇️👀
prelights.biologists.com/highlights/i...

Do you love the monthly #preprint lists on @the-node.bsky.social?

Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.

Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...

October in preprints - the Node Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.

You must have been looking forward to... October in preprints!

Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀

thenode.biologists.com/october-in-p...

Our next #DevPres webinar focusses on regeneration with talks from Stephanie Tsai and Ben Cox @beeeencox.bsky.social.

📆Wed 19 November
🕓16:00 GMT/UTC

For more info and to register: thenode.biologists.com/development-...

Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care - preLights The authors present an “identifiability-guided assessment” framework—a new approach to pinpoint which parameters in a personalized digital twin model can be confidently trusted.

Introducing an “identifiability-guided assessment” framework & applying it to longitudinal Alzheimer’s datasets. 🧠

My Nguyen highlights important work from Juliet Jiang & team #ADNI3study

#neuroscience #preLight ⬇️

prelights.biologists.com/highlights/i...

A major histocompatibility complex (MHC) class II molecule that binds the same viral pathogen peptide with both nonamer and decamer core sequences for presentation to T cells - preLights Do you love fashion shows? Well, chicken’s MHC class II is an immune fashion icon that presents the same viral peptide to T cells in both a 9- and 10-amino acid outfit.

Do you love fashion shows?

Well, chicken’s MHC class II is an immune fashion icon that presents the same viral peptide to T cells in both a 9- and 10-amino acid outfit. 📸✨ #preprint #immunology

First solo #preLight from Mitchell Sarmie ⬇️ 👀
prelights.biologists.com/highlights/a...

100 years timeline Back to 100 years anniversary page

This year we are celebrating our 100-year anniversary. Discover some of the most important milestones on our 100-year timeline: www.biologists.com/100-years/ti...

Evaluating the impact and detectability of mass extinctions on total-evidence dating - preLights Mass extinction can be detected in phylogenetic trees that have been estimated using flawed methodologies.

Mass extinction can be detected in phylogenetic trees that have been estimated using flawed methodologies.

@tomacarruthers.bsky.social discusses a #preprint from Minghao Du & team @ibensens.bsky.social

#evolution #paleontology

#preLight ⬇️
prelights.biologists.com/highlights/e...

Stress granules formed during different RNA virus infections show remarkable plasticity and substantial virus-specific differences in their formation and composition - preLights Naah, MHV plays stress granules like a pro: show up late, strip out the translation machinery, keep your RNA away, and let these 'empty shells' persist while you replicate freely.

2️⃣ Naah, MHV plays stress granules like a pro: show up late, strip out the translation machinery, keep your RNA away, and let these 'empty shells' persist while you replicate freely.

Moh covers a #preprint from @profvolkerthiel.bsky.social & team

#preLight⬇️
prelights.biologists.com/highlights/s...

Computational design of pH-sensitive binders - preLights Designing protein binders computationally requires more than just filling in histidines—you need smarter placement of histidine and other charged amino acids to get truly pH-sensitive protein interact...

Not one, but two new posts from Mohammed Jalloh 🙌

1️⃣ Designing protein binders computationally requires more than just filling in histidines—you need smarter placement of histidine & other charged amino acids #preprint @uwproteindesign.bsky.social

#preLight⬇️
prelights.biologists.com/highlights/c...