preLights

July in preprints - the CellBio edition - preLights

‪July in #Preprints – the CellBio edition - is out.

Thanks to @girishkalephd.bsky.social, Matthew Davies, Barbora Knotkova, and Sristilekha Nath for their contributions.

Have a look! 🍵

TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

@justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!

TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

Excited to announce I recently highlighted another preprint for @prelights.bsky.social. In this preprint, @r-pantier.bsky.social and co-authors from the Chambers Lab at the University of Edinburgh find that the TET proteins act together to help mammalian cells specify into somatic lineages.

Would you like to be the Node’s new Community Manager?

If you're interested in #SciComm and passionate about #DevBio, apply to join the @dev-journal.bsky.social & @biologists.bsky.social team.

Find out more about what the role entails: bit.ly/4otQ2GL

#JobOpportunity

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1 - preLights Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression

Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression.

Check out this #preLight by Sristilekha Nath, which talks about the work by @gsilvani.bsky.social, @kriskilian.bsky.social and the team.

Identifying gaps between scientific and local knowledge in climate change adaptation for northern European agriculture - preLights Agricultural knowledge gaps, or pluralism, depicting, and participation as a route to climate adaptation.

Agricultural knowledge gaps; or pluralism, depicting, and participation as a route to climate adaptation.

A #preLight by @anatoliikozlov.bsky.social, our community manager this summer, talks about the #preprint by Kristina Blennow and the team.

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer - preLights Two is better than one: Pancreatic ductal adenocarcinoma cells can become resistant to treatment with autophagy inhibitors, but combination with pyrimidine analogues shows promise.

Two is better than one: Pancreatic ductal adenocarcinoma cells can become resistant to treatment with autophagy inhibitors, but combination with pyrimidine analogues shows promise.

New #preLight by Hannah Pletcher covers the #preprint of Suzanne Dufresne and colleagues. Have a look!

Synergistic and independent roles for Nodal and FGF in zebrafish CPC migration and asymmetric heart morphogenesis - preLights ‘These signals, they’re made for jogging’: The authors of this study find that Nodal and FGF signals regulate early zebrafish cardiac morphogenetic events and lead to asymmetry in migration patterns t...

‘These signals, they’re made for jogging’:

Nodal and FGF signals regulate early zebrafish cardiac morphogenetic events and lead to asymmetry in migration patterns that result in cardiac jogging and cardiac looping.

Theodora Stougiannou #preLights the #preprint by @rburdine1.bsky.social's team.

And of course, our recent #sciart graphical abstracts wouldn't exist without @sonhita.bsky.social's workshop on visual storytelling we've hosted recently on preLights 🖌️

Better late than never, I am sharing the last #spotlight interviews I did with @prelights.bsky.social at #biologists100 in Liverpool. It was fantastic to get different perspectives on preprints and the publishing world, as well as to hear a bit about the cutting-edge research being presented. (1/5)

Optogenetic control of mechanotransduction based on light-induced homodimerization of talin - preLights Flip a switch, control cell adhesion. Light-controlled talin to control cell adhesion and mechanosignaling - a powerful tool to study how cells sense and respond to their environment.

Flip a switch, control cell adhesion! Light-controlled talin, a powerful tool to study how cells sense and respond to their environment.

Another #sciArt #preLight features graphical abstracts by Barbora Knotkova and Sonhita Chakraborty and presents the work of Ryosuke Nishimura and the team💫

FUS Mislocalization Rewires a Cortical Gene Network to Drive 2 Cognitive and Behavioral Impairment in ALS - preLights Roughly 50% of indivduals with ALS have behavior and cognitive decline, but this is not known why; this study evaluates a biochemical mechanism underlying these impairments in ALS.

~50% of indivduals with ALS have behavior and cognitive decline, but this is not known why; this study explores a biochemical mechanism underlying these impairments.

Check out Taylor Stolberg's #preLight of the work by Raphaelle Cassel et al.

How infant brains fold: Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure - preLights Shaping the postnatal brain - how the grooves of our brain continue to develop after birth.

Shaping the postnatal brain - how the grooves of our brain continue to develop after birth.

A new #SciArt #preLight features graphical abstracts by Jeny Jose and Jawdat Sandakly. It highlights the work of Sarah Tung, Vaidehi Natu and @kalanitgs.bsky.social 's research group.

Many thanks to Ruoheng Li and @prelights.bsky.social for featuring our preprint!

Spurring and Siloing: Identity Navigation in Scientific Writing Among Asian Early-Career Researchers - preLights Does one leave racial identity at the door when communicating science? Can it coexist with scientific ‘objectivity’?

Spurring and Siloing: Identity Navigation in Scientific Writing Among Asian Early-Career Researchers

A new #preLight by Jeny Jose spotlights the #preprint by @devonrgoss.bsky.social and Sarah C. Fankhauser's group, which looked into academic writing as an expression of academic research culture.

Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction - preLights Seeing and (not) believing the role of hypoblast in primitive streak induction

Seeing and (not) believing! On the role of hypoblast in primitive streak induction.

In her second #preLight, Ruoheng Li covers the #preprint by
@aurelienvilledieu.bsky.social and the @jeromegros.bsky.social's research team.

Seconded. Ethan is one of @dev-journal.bsky.social's Pathway to Independence fellows this year, and - on top of his great research programme - has been super-active in the @prelights.bsky.social community.

Check out my first #preLight on the work of Sokol's team exploring PCP and mechanosensation! It was so much fun to pick a preprint, read it, write about it, and even get to ask the authors questions directly. I have a feeling this is just the beginning of many more preLight posts to come! 🙌

Mechanical cues organize planar cell polarity during vertebrate morphogenesis and embryonic wound repair - preLights Stretch it, wound it, pull it: ADIP-Diversin polarizes anyway. Characterization of a new mechanosensitive polarity module.

Stretch it, wound it, pull it: ADIP-Diversin polarizes anyway. Characterization of a new mechanosensitive polarity module 🐸

First #preLight from @alinegrata.bsky.social, highlighting #preprint from Chih-Wen Chu, Satheeja Velayudhan, Sergei Sokol and team:
prelights.biologists.com/highlights/m...

Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders - preLights Pediatric MS has a unique CSF immune fingerprint: a high ASCs-to-myeloid ratio (AMR) that could revolutionize diagnosis and reduce delays in treatment

Pediatric MS has a unique CSF immune fingerprint: a high ASCs-to-myeloid ratio that could revolutionize diagnosis and reduce delays in treatment

In this preLight post, Ala Ferdi and Lyna-Nour Hamidi from uMontreal highlight #preprint from ‪@daespi.bsky.social, Amit Bar-Or and team:

Growing Minds, Integrating Senses: Neural and Computational Insights into Age-related Changes in Audio-Visual and Tactile-Visual Learning in Children - preLights Learning isn’t one-size-fits-all, especially when your brain’s still under construction. This study reveals how kids fine-tune their senses and use feedback to power up thinking.

Learning isn’t one-size-fits-all, especially when your brain’s still under construction. This study reveals how kids fine-tune their senses and use feedback to power up thinking.

#preLight from Clara Vo-Dignard, Sarra Chebaane & Farhan Jahan, discussing #preprint by @ninaraduner.bsky.social & team:

The essential role of connective-tissue cells during axolotl limb regeneration - preLights Axolotl limb regeneration decoded! Connective-tissue cells aren’t just participants – they are essential architects of new limbs. Remove them, and regeneration stalls!

Axolotl limb regeneration decoded! Connective-tissue cells aren’t just participants – they are essential architects of new limbs. Remove them, and regeneration stalls!

First #preLight post from @dhanuush.bsky.social, highlighting #preprint from @murawalalab.bsky.social and team:

Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation - preLights Unraveling the unraveller: novel protein-protein interactions and roles of regulatory protein HNRNPU.

Unraveling the unraveller: novel protein-protein interactions and roles of regulatory protein HNRNPU.

#preLight prepared by Candy Rutihinda, R Bibata Ouédraogo and Bryce Rampal⬇️ 👀 #uMontreal
@umontreal.ca

prelights.biologists.com/highlights/m...

Thank you @prelights.bsky.social & especially Harvey Roveth for selecting our preprint.
"This work...highlights CD24 as a possible therapeutic target in limiting platelet-tumour cell interactions and maybe even metastasis"
prelights.biologists.com/highlights/t...

Tumoral CD24 tunes platelet binding and pro-metastatic functions - preLights Metastatic Matchmaking: CD24 Brings Tumor Cells and Platelets Together

Metastatic Matchmaking: CD24 Brings Tumour Cells and Platelets Together

Check out this excellent #preLight from Harvey Roweth, which includes answers and future directions from the authors of the preprint. ⬇️

prelights.biologists.com/highlights/t...

#platelets #cancer #preprint #tumour

Check out the recent preprints in #cellbio, selected by the @prelights.bsky.social community.

The featured preLight, from @bdmaier.bsky.social,‬ highlights STEAMBOAT, a ML framework for delineation of cellular interactions from @jianma.bsky.social & team.

journals.biologists.com/jcs/article/...

YouTube video by The Company of Biologists spotLights Ep 16: preLights in conversation with Katelyn Cooper

New #Spotlight episode!

@ryanharrison13.bsky.social, Stefan and @reinierprosee.bsky.social talk with Katelyn Cooper, first author of a groundbreaking preprint—the first in-depth analysis of the LGBTQ+ climate in the biological sciences.

#LGBTinSTEM #preprint 🏳️‍🌈🔬

Sugar is usually thought of as a cellular fuel, but it also changes how cells differentiate. preLighter (@prelights.bsky.social) @martinestermann.bsky.social shows that metabolites, such as sugars, influence the development of sex organs—ovaries & testes. Sweet story!

#2025SDB #2025SDB #ICDB2025

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish - preLights Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish

#preLight prepared by Jawdat Sandakly⬇️ 👀

prelights.biologists.com/highlights/t...

Check out this list of posts on @prelights.bsky.social, discussing #preprints in #DevBio and #StemCell biology.

Featured #preLight is by Jethro Lundie-Brown @scicambridge.bsky.social on a preprint by @sumrubayin.bsky.social & co.

journals.biologists.com/dev/article/...