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Maria Mihaylova

@mihaylova.bsky.social

Assistant Professor at the Ohio State University and OSU Comprehensive Cancer Center | Metabolism, Cancer and Aging | views are my own

595 Followers  |  232 Following  |  4 Posts  |  Joined: 21.10.2023  |  1.7736

Latest posts by mihaylova.bsky.social on Bluesky

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πŸ“’WEBSITE LIVE! Excited to announce the date for Stem Cell - Niche Interactions in the Gastrointestinal Tract Conference!

🌞The 3rd meeting in this series will be hosted in Playa Mujeres, Mexico, 07-10 November 2026.

Don't miss out, register now ➑️ bit.ly/4p2aHAS

#FusionStemCells #FusionDevBio

11.11.2025 16:32 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 1

Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions.

www.biorxiv.org/content/10.1...

23.09.2025 12:55 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

In intestinal organoids, SCD inhibition disrupts lipid metabolism, elevates ER stress, and reduces proliferation, effects rescued by oleic acid. In vivo, Scd1/2 loss may be compensated by dietary lipids, but under nutrient stress or DSS-induced injury, regenerative capacity can become compromised.

23.09.2025 12:55 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Excited to share new work led by outstanding former grad student KΓΌbra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.

23.09.2025 12:55 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

excited to share a new preprint from our lab! led by the outstanding (& newly minted PhD) @thebiokimist.bsky.social we first uncover a basis for conditional HK2 essentiality in HPLM - leveraging this dependence then leads us to distinct rationale underlying why the Warburg Effect is beneficial!

10.02.2025 18:40 β€” πŸ‘ 32    πŸ” 16    πŸ’¬ 2    πŸ“Œ 0
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bart simpson is talking to santa claus who is laying in a chair ALT: bart simpson is talking to santa claus who is laying in a chair

Good Sunday, all. What a wonderful collection of papers in #cancermetabolism and #mitochondrialbiology this is! Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social

Happy holiday season to you all!

"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski

22.12.2024 06:37 β€” πŸ‘ 26    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0
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Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! πŸ§ͺ

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧡

18.12.2024 22:40 β€” πŸ‘ 300    πŸ” 96    πŸ’¬ 22    πŸ“Œ 12

Congrats @brunetlab.bsky.social!!

19.12.2024 23:17 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorp...

Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk

27.11.2024 14:42 β€” πŸ‘ 81    πŸ” 21    πŸ’¬ 2    πŸ“Œ 3

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