Andrew Blackford

Congratulations!

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

I am overjoyed to share that I have been selected as a Lundbeck Fellow 2025. Thank you to @lundbeckfonden.bsky.social for their trust in me - My lab and I cannot wait to get started on this important work.

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

A must for all DNA repair aficionados!

Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters

Don’t miss it: dnarepairmeeting-egmond2026.com

Congratulations Ernst, great to see your work in print. Predictomes is a fantastic resource for the field!

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions Schmid and Walter train a classifier that discerns functionally relevant structure predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer, and they use this co...

Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...

PhD fellowships at the Center for Gene Expression

Looking for 2 or more highly motivated PhD students to join our quest to understand the interplay between gene expression, genome instability, and human disease
jobportal.ku.dk/phd/?show=16...
Deadline: March 6, 2025
Please share

Postdoctoral Fellow – DNA Damage Response Inhibitor Sensitisation in Cancer Postdoctoral Fellow – DNA Damage Response Inhibitor Sensitisation in Cancer The Discovery Centre, Cambridge Biomedical Campus, UK Competitive salary and benefits Introduction to role: Do you have expe...

Postdoctoral Fellow position available in the DDR Biology and Functional Genomics teams at AstraZeneca in Cambridge UK. Closing date: 30-Jan-2025 astrazeneca.wd3.myworkdayjobs.com/Emerging-Tal...

Excited to see the final published form of this amazing @drewberry.bsky.social‬ animation of DNA repair go live! Watch your favourite friends BRCA1/2, RPA, RAD51, Exo1, BLM, PCNA, MRN, primase and DNA polymerase perform their recombination magic. Cool educational & scientific tool for our community.

Congratulations Drew, beautiful animation!

Transcription-coupled repair of DNA–protein crosslinks DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple human diseases. They are caused by various endogenous and environmental agents, and from the actions of enzymes...

Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.

www.cell.com/trends/cell-...

RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at

Happy to share our study by Francien Talens and many colleagues on RAD51 foci formation as a functional marker for PARPi sensitivity in ovarian cancer PDX models. academic.oup.com/narcancer/ar...

Beautiful work Alessandro & team, congratulations to all the authors!

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳

Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors!

rdcu.be/d1F7m

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

Time for our first post here 🥳 Our latest paper is online 🙌
We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

Gladly, welcome!

Really interesting and important deep dive into what all scientists kind-of-know but haven't quantified

by @hansonmark.bsky.social
@paolocrosetto.bsky.social
@pagomba.bsky.social
@danbrockington.bsky.social

Sure

Thanks, it's a very useful tool. Do you have future plans to enable it to visualise interactions between proteins that have phosphorylated residues?

Congratulations, fantastic work!

STK19 positions TFIIH for cell-free transcription-coupled DNA repair Together with structural analyses, a cell-free system for transcription-coupled nucleotide excision repair (TC-NER) shows that STK19 is an integral component of the TC-NER complex that couples RNA pol...

Let's get this site started. I'm excited to share that our work on transcription-coupled DNA repair is now published! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples lesion-stalled RNA Pol II to TFIIH. 🧬🐸

➡️ cell.com/cell/fulltex...

Already done :)

Done!

Of course, welcome!

Done :)

Done!

You're welcome! And congratulations on your new position in Heidelberg 🎉

Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvL