Andrew Ellisdon

The image shows a stained section of an invasive ductal carcinoma in a mammary gland.

A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw

Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer A GPCR and a moonlighting transcription factor together drive metastasis in breast cancer.

Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer | Science Signaling www.science.org/doi/10.1126/...

Nvidia supercomputer marks ‘new era’ for Australian AI The world’s most valuable company is building an Australia-first supercomputer that will initially tackle cancer research.

Exciting times for structural biology @monashuniversity.bsky.social from cryo-EM to therapeutic development of new AI-guided therapeutics.

www.theage.com.au/technology/n...

@lorneproteins.bsky.social Meeting with the Lorne Protein Committee to plan for the 2026 and future meetings!
@wehi-research.bsky.social

Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature Communications Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky

www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

Nice review on #TSC and #mTORC highlighting our cryoEM structure of TSC. Phosphorylation mechanisms that modulate TSC activity still remain unknown. TBC1D7 function largely a mystery, but important in brain development / megalencephaly.

Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

Saturn’s northern hexagon in infrared false color. NASA/JPL-Caltech/SSI/CICLOPS/Kevin M. Gill

Saturn’s northern vortex of terror in infrared false color. NASA/JPL-Caltech/SSI/CICLOPS/Kevin M. Gill

Deep in Saturn’s northern hexagon is a 2,000 kilometer (1,250 mile) wide high-wind vortex, seen here in infrared false color. Imaged by Cassini.

flic.kr/p/2g5dxDw
flic.kr/p/2g4xyyQ

Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer - Nature Communications The PEAK family of pseudokinases is known to play oncogenic roles in poor-prognosis triple negative breast cancer (TNBC). Here this group identifies the role of calcium/calmodulin-dependent prote...

Great to see this study published. Congrats to Roger Daly and team! www.nature.com/articles/s41...

a man in a gucci jacket is sitting on a couch and saying over and over again ALT: a man in a gucci jacket is sitting on a couch and saying over and over again

#Autophagy and #mTOR papers from last week, there’s always something to every taste, enjoy thanks to @Bims_BiomedNews pre-selection.

biomed.news/bims-auttor/...

FAMPNN architecture

All-atom fixed backbone protein sequence design with FAMPNN

@richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social

www.biorxiv.org/content/10.1...

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.

Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

Interested in #malaria transmission and fertilisation? Check out our new work using cryo-EM of ENDOGENOUS sexual stage parasites to determine the Pfs230-Pfs48/45 fertilisation complex - please read & share!

structures| nanobodies |human immune responses | mRNA-LNP

www.biorxiv.org/content/10.1...

The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...

Opinion | California, We Feel Your Pain Here in Australia In California’s fire-stoked debate over how aggressively to manage both nature and urban sprawl, Australia can share both empathy and insight.

Must read for California www.nytimes.com/2025/01/25/o...

Thanks Brett! A few more for the list

re-solute.eu/resources/da... (SLCs)
www.flyrnai.org/tools/fly_pr... (excellent)
www.ebi.ac.uk/complexporta...
prodata.swmed.edu/humanPPI/ (excellent)
honiglab.c2b2.columbia.edu/PrePPI/ (unsure)
predictomes.org (small target number)

Any others we've missed?

Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223 Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...

It was perfectly clear last night until about 11pm which allowed me to finally have a good look at the Horsehead Nebula. Here is the result of 61 minutes of data (366 stacked images) from the Seestar S50. Slight enhancement in Lightroom.

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.

New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...

High-resolution cryo-EM using a common LaB6 120-keV
electron microscope equipped with a sub–200-keV
direct electron detector!

Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology of 2025 is ready and full of exciting findings. Don't miss it, check it here:

biomed.news/bims-camemi/...

@biomednews.bsky.social

"I am a book I neither wrote nor read."-Delmore Schwartz

The PDBs for our TSC structure are now available!

To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩

#cryoEM #mTORC1 #TSC

rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social

RCSB PDB - 9CE3: Structure of the TSC:WIPI3 lysosomal recruitment complex Structure of the TSC:WIPI3 lysosomal recruitment complex

The PDB files for the TSC:WIPI3 complex have been released today at the PDB. At 40nm across, it is well worth a look 😀🧪

www.rcsb.org/structure/9CE3

I completely agree. I would only be guessing, but potentially a 12hr vs 24hr clock scheduling mistake?

Did someone mix up AM and PM over at the #NHMRC? I'm all for releasing grant outcomes as soon as possible, but 1:30 AM is a rather unconventional choice!

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1 Endosomal retrieval and recycling of integral cargo proteins is essential for cell, tissue and organ

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1

Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5