Andrew Ellisdon

Resistance Infrastructure | No Mercy / No Malice I’ve struggled my whole life to discern the difference between being right vs. effective. Over the past decade, the U.S. has been on a slow burn to fascism. The best description I’ve seen of America’s...

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📣 New paper alert! This is a story of molecular tricks that let spirochetes (spiral-shaped bacteria) drill through tissue. www.biorxiv.org/content/10.6...

The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.

uq.wd3.myworkdayjobs.com/en-GB/uqcare...

🌀 How do spirochete bacteria swim through thick fluids like champions?

We solved T. denticola flagella structure - asymmetric proteins expand one side, compress the other for perfect corkscrew motion!

@debnathghosal.bsky.social

🔗 doi.org/10.64898/202...

#StructuralBiology #CryoEM #Microbiology

I am delighted to report that our latest paper has now been published in Science Advances:
www.science.org/doi/10.1126/...
In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology.

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...

Do you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.

TSC1 phosphorylation by lysosomal mTORC1 establishes a minimal autoregulatory feedback loop https://www.biorxiv.org/content/10.64898/2026.01.15.699678v1

🤠

Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex #cryoEM

www.nature.com/articles/s41...

Black text on white background. Screenshot of ARC’s Network Message regarding delays to grant announcements because of new security arrangements.

⁉️The ARC has delayed outcomes of ALL grants 1–4 months & increased scheduled outcome windows from 2 weeks to 3 months!

This reverses 4 years of progress in providing greater certainty & ability to plan for researchers, their families & unis.

Their excuse? Security checks under new ARC legislation👇

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-i...

You can find out more here: www.cell.com/cell/fulltex...

The latest research from our team is out in Cell @cp-cell.bsky.social! We used #cryo-EM, #imaging, #BRET, and #biosensors targeted to the lysosome to understand how the KICSTOR-GATOR1 complex turns off #mTORC1 in response to low levels of amino acids.

Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading

"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex pubmed.ncbi.nlm.nih.gov/41512879/ #cryoEM

The #ChlamyDataset is on the cover of @cp-molcell.bsky.social 🖼️🥰!

Read @lifeonthewedge.bsky.social's great thread🧵 for the inside scoop🍨 on all the #TeamTomo developments already made possible since these 1829 tomos hit EMPIAR 🧪 🧶🧬

For more, here's the old preprint thread:
bsky.app/profile/cell...

The study was an excellent collaboration between researchers across @monashuniversity.bsky.social and was funded by the NHMRC. Research was driven over many years by the hard work of first authors @luptoncj.bsky.social and @charlesbj.bsky.social and co-led with Tyler Chang and @drmlhalls.bsky.social

An incredibly challenging single particle cryo-EM structure. Capturing both the N and C termini was difficult enough, but the project required a major effort to resolve the full length protein structure to capture the overall architecture of the KICSTOR-GATOR1 complex.

Well worth it in the end!

Excited to share our latest research, out today in Cell (@cellpress.bsky.social)

Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling.

Read the paper here: doi.org/10.1016/j.ce...

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation.

Now online! Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

Thrilled to share our latest work @luptoncj.bsky.social @drellisdon.bsky.social @drmlhalls.bsky.social.

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.

🧪🔬#cryoEM
Now online @cellpress.bsky.social.

doi.org/10.1016/j.ce...

A very brief break in the clouds over Melbourne last night. The universe is stunning.

Depletion of individual dietary amino acids induce distinct metabolic and chromatin states Reducing dietary levels of protein or specific essential amino acids (EAAs) promotes favorable metabolic reprogramming, including improved glucose tolerance, increased insulin sensitivity and reduced ...

This long-awaited article demonstrates that depletion of individual essential amino acids induces profound changes in the liver epigenome, with AA-specific molecular changes at the level of histone PTMs, the transcriptome, and metabolome www.jbc.org/article/S002...

Blender rendering of TLR4 in membrane and TIRAP fibrils at the plamsma membrane.

Blender rendering of TLR4 in membrane and TIRAP fibrils at the plamsma membrane. View from the cytosol.

In our new preprint, we show how fibril-dynamics of signaling component TIRAP supports sensitive & fast sensing of endotoxin LPS. Congrats to co-lead @arthurfelker.bsky.social. @piehlerlab.bsky.social @arnemoeller.bsky.social #TLR #cryoEM #blender doi.org/10.64898/202...

Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Jacqmin, Boonen et al. report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in #lysosome #trafficking & disruption of the mTOR–TFEB pathway. rupress.org/jcb/article/...

Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins - Nature Communications ABC toxins are bacterial insecticides with biotechnological potential. Here, Low et al. have deciphered soluble and membrane-inserted structures of YenTc that highlight structural and mechanistic dive...

Congratulations to the Landsberg lab for a fantastic paper in Nat Comms on the structure of the YenTC toxin. Led by Yu Shang Low and Solace Roche. @dr-berger.bsky.social @sarahjpiper.bsky.social

This work started more than 5 years ago and combines molecular phylogenetics, diversification models, paleoecology and micropaleontology, requiring ~136 CPU-years 🧬💻! A lovely interdisciplinary collaboration with @phoebefossil.bsky.social, Hélèn Morlon and @fburki.bsky.social.
#ProtistsOnSky

The image shows a stained section of an invasive ductal carcinoma in a mammary gland.

A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw