This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
13.09.2025 00:04 โ ๐ 259 ๐ 81 ๐ฌ 18 ๐ 12
This composition is a tribute to the legendary Bill Jacobs, who isolated the Bxb1 phage-aka the 'Bronx Bomber'-from the dirt in his backyard in the Bronx, NY. ๐ฆ ๐ ๐ฝ
A true classic in #phage lore! #tuberculosis
08.07.2025 21:28 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
#NotTheCover @cellpress.bsky.social ...but, weโre still pretty proud of it! ๐ Had an awesome time putting this together with the amazing @kfreeman.bsky.social and @raphaelpark.bsky.social What a ride! ๐
#SciArt #CryoET #CryoEM
Paper๐ www.cell.com/cell/fulltex...
08.07.2025 21:28 โ ๐ 5 ๐ 0 ๐ฌ 1 ๐ 0
The very first structural images of a tuberculosis-fighting virus
New insights could advance phage therapies for the worldโs deadliest bacteriaโincluding drug-resistant strains.
www.scripps.edu/news...
18.05.2025 18:21 โ ๐ 7 ๐ 5 ๐ฌ 0 ๐ 0
@science.org ๐งซ๐งฌโ๏ธ๐ฌ Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase
15.05.2025 23:11 โ ๐ 90 ๐ 21 ๐ฌ 3 ๐ 3
The very first structural images of a tuberculosis-fighting virus
Scripps Research and @pittofficial.bsky.social capture the first cryo-EM & cryo-ET images of a virus infecting TB-causing Mycobacteria, revealing an unexpected infection mechanism that could inform phage therapies for drug-resistant TB, per @cellpress.bsky.social.
23.04.2025 17:37 โ ๐ 16 ๐ 4 ๐ฌ 0 ๐ 0
Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! ๐งช๐งถ๐งฌ๐ฌ
18.04.2025 19:55 โ ๐ 19 ๐ 5 ๐ฌ 1 ๐ 0
Host invasion by a mycobacteriophageโvisualized in action! ๐ฆ โจ
Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity ๐ #CryoEM #CryoET #phage #mycobacteria
17.04.2025 00:58 โ ๐ 9 ๐ 2 ๐ฌ 1 ๐ 1
Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Great chats, exciting posters and the chance to meet both legends in the field and awesome new peersโฆ
#mycobacteria
11.04.2025 16:28 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
Lecturer at Bangor University. Environmental virologist, working on phages. Scientific illustrator. Shop: http://redbubble.com/people/Jellie Website: https://elliejameson.wordpress.com YouTube: https://www.youtube.com/channel/UCNM-pdh9jd
Basic. Cell Biologist. Lipid signaling and phosphoinositide enthusiast.
laboratory on structure and functions of living membranes lab at University of Virginia ; also posts occasional nonsense - views our own, not UVA
www.levental-lab.com
Chemist in a CellBio place. Fan of lipids & membranes
Asst Prof of Molecular Cell Biology and Computational Biology at UC Berkeley
Building a new lab capturing close-ups of cells with electrons. lucaslab.science
Attempting to "dwell (somewhat) patiently in the variety and complexity of organisms."
IZTECH-Chemistry, I like to be Polymath(learning different subjects), Polygot(interested in the learning different languages) comments and opinions are my own RTโ is not endorsement (he/him)
Membrane Biology of Viral Infection
cryo-ET, cryo-CLEM, cryo-FIB, influenza, Ebola virus, SARS-CoV-2
A scientific journal publishing cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Posts by the editors.
Postdoc@Landerlab
alumnus of @CSIR_CCMB
Scripps Research is one of the world's largest, private, non-profit biomedical research organizations. We are Science Changing Life.
Interested in Structural Biology, deep learning, NextFlow, HPC, viruses, missense mutations archaea, bacteria, evolution & random quirks of nature. (Protein Cosmos feed ๐งถ๐งฌ) Leads a research group & Structural biology Facility,UNSW Sydney. Opinions my own.
Computational protein engineering & synthetic biochemistry
Opinions my own
https://linktr.ee/ddelalamo
Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the Linderstrรธm-Lang Centre for Protein Science, University of Copenhagen ๐ฉ๐ฐ
Molecular & structural biologist CNRS with a big respect for Transcription Factors, RNA Pol II & Mediator
#CryoEM #ESR
Advocating for #basicresearch #womeninSTEM #preprint
Message in English or French.
https://bsi-lille.cnrs.fr
The "The Dialectical Biologist" account.
Structural biology & anti-racism.
Loves: birds, proteins, Linux, Lewontin
Hates: race science, racists, transphobes
Computational structural biologist @Fox Chase Cancer Center. Gay, out & proud since 1986. I support transgender & nonbinary people. Living with CLL/SLL. Video about my LGBTQ+ life in science: https://tinyurl.com/45srzjdw. Views my own, not my employer's.
Developing macromolecular structure resources and tools for life science.
- Founding partner of the wwPDB.
- Manage the community-led PDBe-KB resource and the AlphaFold Protein Structure Database, a collaboration with Google DeepMind.
- Part of EMBL-EBI
RCSB PDB (RCSB.org) promotes a structural view of biology. Funded by NSF, NCI, NIAID, NIGMS, NIH, and DOE
