Ching-Lung Hsu

The influence of cortical activity on perception depends on behavioral state and sensory context - Nature Communications The mechanistic link between cortical activity and behaviors remains largely unclear. Here authors show that targeted holographic photostimulation of mouse visual cortex during a detection task alters...

www.nature.com/articles/s41...

In case you don't know already, the journal Open Mind has a Bluesky account that automatically posts new papers:
@openmindjournal.bsky.social

The journal is diamond open access (free to read, free to publish) thanks to the support of MIT Press, Harvard Library, & MIT Library.

doi.org/10.1016/j.cu...

Contents of visual predictions oscillate at alpha frequencies Predictions of future events have a major impact on how we process sensory signals. However, it remains unclear how the brain keeps predictions online in anticipation of future inputs. Here, we combin...

doi.org/10.1523/JNEU...

Congrats @jeromeepsztein.bsky.social

I second this recommendation. Especially for more junior scientists, I think these kinds of public discourse can be quite educational.

Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement Xuan et al. measure release of the brain modulation chemical acetylcholine in the mouse hippocampus with micron scale and sub-second resolution. They find increases in release related to heightened at...

Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement: Cell Reports www.cell.com/cell-reports...

β‐Adrenergic Receptor Activation Modulates the Induction of Complex Spike‐Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity Norepinephrine, acting through β-adrenergic receptors (β-ARs), has a key role in hippocampus-dependent forms of learning. Although β-AR activation also facilitates the induction of Hebbian LTP, recen....

Cool work!
doi.org/10.1002/hipo...

Taiwan Precision Medicine Initiative (TPMI) has made a historic advance on the genetics of Han Chinese as two back-to-back Nature papers. #Nature

Open House of Academia Sinica, let’s celebrate the research from Taiwan with Cathy Fann from Institute of Biomedical Sciences (IBMS)! #PrecisionMedicine

Neuromorphic is dead. Long live neuromorphic. In this NeuroView, Giacomo Indiveri discusses the origins and evolution of neuromorphic engineering, reflects on recent shifts toward digital and AI-centric approaches, and advocates for a revival of ...

Is neuromorphic dead?
www.cell.com/neuron/fullt...

A parabrachial hub for need-state control of enduring pain - Nature Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

www.nature.com/articles/s41...

Thalamus enables active dendritic coupling of inputs arriving at different cortical layers - Nature Communications How the brain combines sensory with non-sensory information is unknown. Here, the authors find that sensory input from the thalamus to the apical dendrites of the main cortical output neurons enables ...

Interesting paper!
www.nature.com/articles/s41...

It’s an interesting point @hannah-haberkern.bsky.social though, I would speculate—isn’t that some forms of art “made from individuality”, yet aimed at seeking commonalities of human nature?

Well put! @apeyrache.bsky.social

More scientists to truly engage with art not through a simple analytical lens or an intellectual arrogance is a key!

Great comments Sam. I'm of course with Sacks, for the reasons you put. I used to do a fair bit with art, but the funding to support collaboration dwindled, and it was hard running a lab that did all that...
See @wellcometrust.bsky.social funded project Pattern Completion:
www.pattern-completion.net

I'd love to see more scientists engage with art, not as scientists but as people. Not for any instrumental purpose but simply as part of human experience.

System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning - Cell Research Cell Research - System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning

www.nature.com/articles/s41...

Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.

www.nature.com/articles/s41...

Quantum imaging with a photon counting camera - Scientific Reports Scientific Reports - Quantum imaging with a photon counting camera

www.nature.com/articles/s41...

Hippocampal CA2 to CA1: A metaplastic switch for memory encoding | PNAS The hippocampus is essential for spatial and episodic memory, subserved by CA1 neurons. Hippocampal area CA2, which processes social memory, also m...

New function for excitatory input to the basals of the CA1
www.pnas.org/doi/10.1073/...

A powerful collaboration with Richard! @neuronaud.bsky.social

It's officially been 75 years since the proposal of the Turing Test, a good time bring up 'The Minimal Turing Test':

www.sciencedirect.com/science/arti...

I was honored to speak up with my colleagues from across the government to demand Congress fight for the American people.

Thank you Aaron! We should talk about this :)

Norepinephrine signals through astrocytes to modulate synapses Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

www.science.org/doi/10.1126/...

Sequential predictive learning is a unifying theory for hippocampal representation and replay The mammalian hippocampus contains a cognitive map that represents an animal’s position in the environment [1][1] and generates offline “replay” [2][2],[3][3] for the purposes of recall [4][4], planni...

Beautiful work, as I'm thinking about the algorithmic functions of hippocampal theta!
doi.org/10.1101/2024...

Sequential predictive learning is a unifying theory for hippocampal representation and replay The mammalian hippocampus contains a cognitive map that represents an animal’s position in the environment [1][1] and generates offline “replay” [2][2],[3][3] for the purposes of recall [4][4], planni...

Very interesting work.
doi.org/10.1101/2024...

Flexible multitask computation in recurrent networks utilizes shared dynamical motifs - Nature Neuroscience The authors identify reusable ‘dynamical motifs’ in artificial neural networks. These motifs enable flexible recombination of previously learned capabilities, promoting modular, compositional computation and rapid transfer learning. This discovery sheds light on the fundamental building blocks of intelligent behavior.

www.nature.com/articles/s41...

Recurrent pattern completion drives the neocortical representation of sensory inference - Nature Neuroscience Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by selectively reinforcing activity patterns that match prior expectations.

Amazing!
www.nature.com/articles/s41...