Maren Salla

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...

🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉 www.biorxiv.org/content/10.1...

24.09.2025 12:39 — 👍 22    🔁 10    💬 2    📌 1

Frontiers | Generation of decellularized human brain tissue for investigating cell-matrix interactions: a proof-of-concept study The brain extracellular matrix (ECM) regulates myelin repair and regeneration following a demyelinating event by interacting with neuronal progenitors and im...

Exciting new method to decellularize human brain tissue - opening up ways to study stem cell differentiation or how the ECM shapes immune responses. Great work by Roemel Jeusep Bueno and team!

www.frontiersin.org/journals/bio...

07.06.2025 19:11 — 👍 0    🔁 0    💬 0    📌 0

Thanks for this inspiring & fun workshop 🌓🧬

21.05.2025 16:55 — 👍 3    🔁 0    💬 1    📌 0

We had two great 'Night Science' workshops on the creative scientific process in Heidelberg yesterday (at EMBL and at the EMBO PhD Course). Here are the slides if you're interested in running something like this at your place! docs.google.com/presentation...

20.05.2025 22:24 — 👍 48    🔁 11    💬 1    📌 2

Check out our CRISPR/Cas9 methods paper, online on arxiv! 🚀🧬

19.02.2025 09:04 — 👍 6    🔁 3    💬 0    📌 0

Mitochondrial single cell-multi-omics for lineage tracing and genetics

Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference!

www.isco-conference.eu

www.mdc-berlin.de/news/events/...

31.01.2025 10:36 — 👍 9    🔁 5    💬 0    📌 1

Join us to connect with the vibrant #singlecell community.
📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin!
🗓️ 12-13 May 2025
🎤 Fantastic Keynote and Invited Speakers
🫵🏿 Many slots for talks: submit your abstract
🔗http://isco-conference.eu
Please spread the word!

31.01.2025 10:29 — 👍 14    🔁 9    💬 1    📌 1

Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

27.01.2025 23:26 — 👍 154    🔁 49    💬 2    📌 2

#savebraincity

Science, Education, and Culture is worth spending Money on!

19.12.2024 10:05 — 👍 5    🔁 3    💬 0    📌 0

This is figure 2, which shows that biobanks support advances in precision medicine research.

A Review in Nature Reviews Genetics discusses how biobanks facilitate genetics research towards advancing precision medicine and overviews potential solutions to their current limitations. https://go.nature.com/3OLSnw1 🔒

09.12.2024 13:43 — 👍 30    🔁 5    💬 0    📌 1

Nature Neuroscience - Focus on single-cell genomics in neuroscience Single-cell and single-nucleus genomics pave the way for a comprehensive understanding of the nervous system and its diverse cell populations. Realizing this...

The December issue of Nature Neuroscience is now live, featuring our Focus on Single-Cell Genomics! We hope that these consensus reviews from experts in the field will serve as a useful guide for neuroscientists regarding best practices for these approaches.

www.nature.com/neuro/volume...

03.12.2024 19:49 — 👍 82    🔁 21    💬 1    📌 0