Jim Hughes

Characterization of hereditary tumor risk in individuals with SDHA germline variants. 10610Background: Paragangliomas (PGLs) are rare neuroendocrine tumors with a high degree of heritability; up to 30% of individuals diagnosed with a PGL are estimated to have a germline pathogenic vari...

ascopubs.org/doi/10.1200/...

Single Nuclei-Derived Molecular Subtypes of Gastrointestinal Stromal Tumors Correlate with Clinicopathologic Features and Predict Clinical Outcomes Historically, gastrointestinal stromal tumor (GIST) has been subtyped by oncogenic driver mutations. However, tumors with the same mutational profile can have variable biology. To further explore the ...

www.biorxiv.org/content/10.1...

Genome‐Wide DNA Methylation and Copy Number Alterations in Gastrointestinal Stromal Tumors Gastrointestinal stromal tumors (GISTs) span a broad clinical spectrum, from indolent neoplasms to life-threatening metastatic tumors. A persistent limitation of current risk stratification systems i....

onlinelibrary.wiley.com/doi/10.1002/...

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles - Nature Communications The genomic landscape of hereditary SDHB-mutant pheochromocytomas (PC) and paragangliomas (PG) remains to be explored. Here, the authors perform multiomic analysis on 94 tumours from 79 patients and i...

www.nature.com/articles/s41...

Recent Advances in Succinate Dehydrogenase Deficient Gastrointestinal Stromal Tumor Systemic Therapies - Current Treatment Options in Oncology Gastrointestinal stromal tumors (GIST) are the most common gastrointestinal soft tissue sarcomas, with an incidence of about 15 cases per million person-years. Approximately 15% of GIST develop due to...

link.springer.com/article/10.1...

The LRG's Sara Rothschild was on the road in #Texas this week meeting with some amazing LRG members & community partners. These moments remind us why community matters— no one should navigate GIST alone.💙 #GISTCommunity #ThrivingTogether #PatientVoices

A new collaborative study led by Dr. Samantha Greenberg, with members of the Pediatric & SDH-Deficient GIST Consortium and the LRG, aims to improve genomic testing for #SDH-deficient GIST. bit.ly/GenomicStudy #GISTEducation #ThrivingTogether

Becky and Rich, our Valentine’s Feature of the Month, share their journey of strength and support through life’s challenges. bit.ly/POMFeb2025 #thrivingtogether #patientofthemonth #memberstory

A Review of Genomic Testing and SDH‐ Deficiency in Gastrointestinal Stromal Tumors: Getting to the GIST Gastrointestinal Stromal Tumors (GISTs) have seen significant advancements in their diagnosis and management, driven by targeted therapeutic development and molecular testing. The identification of m...

onlinelibrary.wiley.com/doi/10.1002/...

Join us in Houston on March 1 to learn, connect, and empower the GIST community! Register now: bit.ly/GISTSummit2025-GDOL #GISTSummit #GDOLTexas #GISTEducation

Just once more sleeping. And then its #fortressmeeting again. Team Essen is looking forward to a meeting full of ❤️💘🌹 and science. Both currently not much en vogue in some places. #fightforthecureofsarcomas
www.fortressmeeting.com
www.sarkomtour.de