GoisLab

Exercise day...the group is working hard 😀

Our latest article on B chemistry @boron-chemistry.bsky.social is featured on the cover of ChemistryEurope @chemistryeurope.bsky.social (chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...) : from new Lewis superacids/pyridine pairs to unusual binding modes with WCAs and B-N bis-triptycenes.

It's just starting the EFMC-ASMC - Porto.

Hey Peeps,

I have a fully funded 3-year PhD studentship available in my group on the development of new synthetic methodologies with applications in medicinal chemistry - it is for UK home students only unfortunately. Please email me if you are interested.

@qmul.bsky.social

GoisLab on Pavilhão do Conhecimento celebrating the Children's Day with Boron - Not Boring

Lessons from the Iberian Outage: Chemistry Must Be Resilient, Not Just Sustainable - ChemistryViews Lessons from the Iberian Outage: Chemistry Must Be Resilient, Not Just Sustainable: Ten principles want to encourage dialogue and research into how chemistry can withstand energy volatility, resource ...

This was our take on living the outage during the 9PyChem in Faro, Portugal. Hope it helps. Huge thanks to Martyn for leading this work.

Check out this article on ChemistryViews: www.chemistryviews.org/lessons-from...

It is a beautiful date!!! Let’s remember its meaning for all of us! 💐❤️

It's also the liberation day in Portugal. On this day 50 years ago the militaries ended a 48 year fascist regime! The carnation revolution is still celebrated every year in the streets. A photo from last year's party.

What a great time in Palermo! What a warm hospitality by @bip-unipa.bsky.social @giampaolobarone.bsky.social @alessioterenzi.bsky.social @rbonsignore-unipa.bsky.social @luisa797.bsky.social

Orthogonally conjugated phthalocyanine-porphyrin oligomer for NIR photothermal-photodynamic antibacterial treatment Communications Chemistry, Published online: 14 March 2025; doi:10.1038/s42004-025-01470-wWith the increase in antibiotic resistance worldwide, light-induced phototherapies, including photodynamic and photothermal therapy, have attracted interest due to…

Just out: Orthogonally conjugated phthalocyanine-porphyrin oligomer for NIR photothermal-photodynamic antibacterial treatment

Press conference by Christian EHLER (EPP, DE) rapporteur, on the implementation of the Horizon Europe programme - Multimedia Centre The multimedia platform of the European Parliament is the official public available repository of the media production of the Secretariat of the European Parliament, managed by the Directorate-General...

More good news:
MEP Christian Ehler's ITRE report adopted by the European Parliament: strong support for an expanded and independent ERC.
Happy with the proposal of €220 billion for the EU's next research framework programme! Thank you!
Press briefing
multimedia.europarl.europa.eu/en/webstream...

The NIH "Fellowships: Topics in biochemistry and chemical biology" Study Section scheduled for March 20th/21st has just been postponed...

BF3-induced reversible covalent organic framework radicals
@boron-chemistry.bsky.social @mofpapers.bsky.social

doi.org/10.1002/smm2...

📣Good news! We are looking for 2 motivated PhD students to work on the development of photocat. reactions! If you want to experience a PhD program in an international environment, with industrial applications, on a highly exciting subject, click here:
👉 eq51power.wixsite.com/power/group-...

Congratulations Arnaud, well done!

Portuguese editorial cartoonist Zez Vaz reaches back to Tiananmen Square to call on American defiance.

Register here before tomorrow: www.pslchembiol.com/registration

Designing Functional and Responsive Molecules with Boronic Acids ConspectusBoronic acids (BAs) are one of the most important classes of reagents in modern synthesis, enabling a wide range of powerful transformations that facilitate the formation of key carbon–carbon and carbon–heteroatom bonds. While their success as reagents is well-known, their remarkable potential as building blocks for creating functional molecules is often overlooked.At the core of BAs’ uniqueness is their ability to form reversible covalent bonds, thanks to the interconversion of the boron atom between its uncharged trigonal planar structure and an anionic sp3-hybridized form. This coordination chemistry has paved the way for exciting developments in fields such as medicinal chemistry and chemical biology. In recent years, BAs have been used to create a wide variety of materials, including small-molecule drugs, bioconjugates, drug delivery vehicles, polymeric nanomaterials, sensors, and even photosensitizers. What makes this strategy particularly unique is the structural diversity that can be achieved by functionalizing the BA coordination sphere, along with the possibility of incorporating stimuli-responsive mechanisms. This reactivity is further enhanced by the well-known oxidation of BAs in the presence of reactive oxygen species (ROS).A detailed understanding of the mechanisms governing the dynamic nature of BAs enables the engineering of sophisticated materials that can respond to specific molecular stimuli, such as changes in pH, carbohydrate or glutathione concentrations, and hydrogen peroxide. These stimuli are often key indicators of diseases such as cancer, inflammation, and neurodegeneration, placing BAs at the forefront of tools for designing materials that can potentially influence the mechanisms behind these diseases.In this Account, we draw on our group’s expertise to explore the exciting potential of BAs in the design of functional materials. The focus is on the response of different boron complexes to biologically relevant stimuli. We describe the preparation of boronated esters (BEs), BA–salicylhydroxamic acid (BA–SHA) complexes, iminoboronates, diazaborines, and boronated thiazolidines and discuss how these chemotypes respond to disease-relevant triggers. Given the growing importance of using external stimuli to control the efficacy of modern drugs, we also explore how some of these compounds respond to specific chemicals. While this Account is not meant to be an exhaustive survey of every example of BA stimulus-responsiveness, we aim to integrate existing chemotypes and their chemical triggers. Our goal is to provide an overview of the mechanisms enabled by BAs for designing functional materials that could one day lead to innovative therapeutic options for human diseases.

Our Account on the use of boronic acids to design functional and responsive molecules | Accounts of Chemical Research. Thank you João, Ines and Fábio @labgois.bsky.social @pubs.acs.org pubs.acs.org/doi/10.1021/...

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find!

www.nature.com/articles/s41...

Reaction development: a student's checklist So you’ve discovered a reaction. But how do you turn this new discovery into a fully-fledged program that maximises the potential of your novel transformation? Herein, we provide a student's checklist...

Scholarly review written by @DirkTrauner and @GloriusGroup:

Reaction development: a student's checklist📜☑️😀

Published in Chem. Soc. Rev.
doi.org/10.1039/d4cs...

Here is a tentative Supramolecular Chemistry starter kit. Please let me know if you wish to be added ! #ChemSky
go.bsky.app/RjRgi6n

Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏

www.nature.com/articles/s41...

Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism Systemic metabolism ensures energy homeostasis through inter-organ crosstalk regulating thermogenic adipose tissue. Unlike the well-described inductiv…

The prominence of the pervasive PIEZO ion channels keeps showing up, now for regulating adipose tissue glucose uptake and energy storage
www.sciencedirect.com/science/arti...
Recently discussed w/ @ardemp.bskyverified.social erictopol.substack.com/p/ardem-pata...

I am teaching my favorite course again this semester:
"Chemical Neuroscience - a Synthetic Approach".
We are posting some materials online, check them out.

www.traunergroup.org/teaching

📢 Announcing the 2025 EFMC-YSN Leadership Election!

We are glad to introduce Sean McKenna, Laia Josa-Culleré, and Etienne Donckele as the new leaders of the Young Scientists Network.

Congratulations! Reach out for future collaborations!

@seanmckenna.bsky.social
@laiajosacullere.bsky.social

Just landed here!