Fernán Agüero

Everyone you meet is fighting a battle you know nothing about. Be kind. Always…

Paper alert 📢: What drives variation in humoral responses to viruses? collab with @etienne-patin.bsky.social @darraghduffy.bsky.social @lquintanamurci.bsky.social we show that for ~98k viral epitopes immunodominance vary by genetics, sex and origin: www.nature.com/articles/s41...

The MIBiG 5.0 Annotathon is coming soon, and registration is now open!

🧬 Does your research involve biosynthetic gene clusters? Do you love natural product biosynthesis? Do you have an interest in rare & exotic enzymes? We can use your help & expertise.

Register here 👉 forms.gle/C1cWcLHtrjT2...

Staff scientists shouldn’t feel invisible. We deserve more voice “I felt valued but not included,” this staff scientist writes

"I urge those in positions of power to think about how their current structures might render nonfaculty contributions invisible. We’re all valuable cogs in the system"

www.science.org/content/arti...

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei https://www.biorxiv.org/content/10.64898/2026.02.19.706783v1

sorry Pink Floyd, turns out that we needed education. a lot of it. all of the education, really

Thank you - I Love Free Software Day

❤️ Happy I Love Free Software Day!

OpenProject is fully GPLv3 Free Software – across all editions.

But free software doesn’t maintain itself. It takes dedicated maintainers, contributors, and long-term commitment.

Thank you to everyone who makes it possible 💙

#ilovefs #GPLv3 #OpenSource

Applications for our training course, 'Bioinformatics for immunologists' are open until 15 March 2026: www.ebi.ac.uk/training/eve...

Travel grants and fee waivers are available for this essential bioinformatics training course.

🧬🖥️📊🎗️

I’ve recorded ~8h explaining the architectures of AlphaFold, AF2 & AF3, as well as the context needed to understand their development, applications and limitations :)
youtu.be/_jDRr5BcTaY

Slides
drive.google.com/file/d/1i4QE...

English is available only via auto-translated subtitles

Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...

Pfs48/45 nanobodies block Plasmodium falciparum transmission Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...

Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎

Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕

Please share widely- love to hear your feedback!

📢 #BSCSeminar: “Guiding directed evolution of enzymes”.

🗣️ Rocio Espada, University of Buenos Aires
📆 04 February

➡️ bsc.es/4JB

#EquityinBSC #WomeninBSC

@sommalliance.bsky.social

🚀 InterPro 108.0 is live!
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/

On World NTD Day, we are highlighting innovative approaches to fighting NTDs.

A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans.

👉Read more: bit.ly/47WdrXA

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...

⚕️Tomorrow is #WorldNTDDay🌐2026, and Chagas Coalition will be supporting it through a webinar with our colleagues from PAHO & @dndi.org. It's about data management related to these 21 neglected diseases

✍️ paho-org.zoom.us/webinar/regi...

On January 30, let's #BeatNTDs & call for #UniteActEliminate

PhD position in my team at @pasteur.fr ! The selected canddiate will work on the development of new methods combining biophysicial and machine learning modelling for single-cell multi-omics spatiotemporal data.

emploi.cnrs.fr/Offres/Docto...

The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe | mBio Names matter; they are not mere labels. They operate as anchors of memory, social coordinates, and references of collective identity. When a name becomes established through long-term use and broad ad...

Should an iconic #bacterial #chassis be renamed without community consensus? Our @mbio.bsky.social #article vindicates the established identity of #Pseudomonas putida KT2440 & argues for continuity, community practice & common sense in naming · @vdlorenzo.bsky.social
journals.asm.org/doi/10.1128/...

Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money An analysis of 100,000 special issues of academic journals reveals that one in eight is filled with articles written by the editor, particularly at the publisher MDPI

Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money
1 in 8 'special issues' is filled with articles written by the editor, particularly at the publisher MDPI
@manuelansede.bsky.social
english.elpais.com/science-tech...

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...

Excited to share a new story that transformed how we think about membrane domains in the ER!

rdcu.be/eR7Cn

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export

Wondering what’s so new and exciting? Skytorial below!

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The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA @cincyresearch.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...

Vaccinia virus mRNAs containing long 5′-poly(A)-leaders lack a canonical 5′-methylguanosine cap Nature Communications - The vaccinia virus produces mRNA lacking the 5′ m7G cap structure. These uncapped mRNAs have long poly(A) leaders and dominate late in infection, suggesting a novel...

A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression.

More: rdcu.be/eXksT

Mucosal immune responses to Bordetella pertussis in Gambian infants after maternal and primary vaccination: an immunological substudy of a single-centre, randomised, controlled, double-blind, phase 4 ... Tdap–IPV vaccination during pregnancy induces antibodies that are transferred across the placenta to reach the upper airway mucosa of the infant and could contribute to local protection. Although mate...

This is really cool. Who said IgG can't protect the mucosae? #immunosky

www.thelancet.com/journals/lan...

ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.

#Virology

Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process

Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)?

This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec

Photograph from 1911 taken by Herbert Ponting whilst with Scott's Antarctic Expedition The monochrome photo is taken from within a cave. The walls of the cave are made of ice. The cave entrance is in the mid distance with two figures standing looking out towards a distant ship. Between them and the ship there is first a 'beach' of ice before the sea itself. The ship could be up to 800 metres away What makes the photo so special is that where the figures are at the cave entrance there is a band of very white snow and ice (contrasting with the comparatively dark inside of the cave) that creates a stark framework in which the men and the ship are captured. It is made even more dramatic by the fact that the cave entrance is at least 30 metres high and is in the shape of a distorted elipse with the tail sloping off to the right at the top of the elipse The photo being in monochrome in a largely white environment makes the photographers skill all the more laudable

This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,

The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance

Iconic imo

Here is the link to the paper
pubs.acs.org/doi/full/10...

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And we also tested combinations of these together with the current approved drug for #Chagas disease (Benznidazole)

Here are the synergy distribution maps:
• synergy = red
• antagonism = green
• additive = white

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AR-12 (OSU-03012) is a celecoxib derivative that doesn't inhibit cyclooxygenase. Its most studied target is the PDK1 kinase.

Fosmanogepix is a broad spectrum antifungal prodrug that targets the GWT1 enzyme in the GPI anchor biosynthesis pathway.

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