Thibault Mayor

I survived the 2025 EMBO protein quality control meeting - it was amazing despite a defective projector on day 1, and epileptic crisis on day 2, a black out in day 3, and we all got a shaky wake up call ~6am on day 5 by an earthquake… never a dull moment but most importantly great science

We ran over 200 eggaggregation experiments for Science Rendezvous - a blast!

4 months after biorxiv submission sounds like a smooth ride - congrats

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out!
meetings.cshl.edu/courses.aspx...

Here’s a quick throwback to celebrate the last day of winter: curling with the lab!

Some of you will recognize this - I am done with our CIHR application. Just in time to start teaching a big course section ✌️

Research Associate Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Wasserman Laboratory | Department of Medical Genetics | Faculty of Medicine (Wyeth Wasserman) Posting End Date Febr...

Bioinformatics Job Opportunity
Research Associate / Staff Scientist
Vancouver Canada

Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis

tinyurl.com/bm4ptux3

Priority to Canadians

Please repost

Canada Research Chair - Indigenous Health and Well-Being

Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please):

www.sfu.ca/vpacademic/a...

I enjoyed both @cherisirois.bsky.social presentation and conversation about the publishing world and Cell Press today

With the help of e@UBC our BMB and MSL postdocs organized this great 1/2 day Academia to Industry workshop with a focus on entrepreneurship today

You almost look like Leonard on that picture ;-)

Happy birthday- enjoy the rest of the trip

Even though David Baker's presentation was online, it was rad and inspiring. I really enjoyed today's session on machine learning at the 2025 PepTalk & BioLogic Summit

Calling early-career colleagues with stories of racism / sexism / microaggressions to share (anonymously or not) for an article someone I know is doing! Please send me a DM asap. They'd need to interview you tomorrow (Tues). It's important these stories are shared, so please do reach out!

Many people contributed to this project led by @hthrbaker.bsky.social with help from @shriyakamat.bsky.social and great collaborators in @miketilapia.bsky.social and Brian Raught's labs

The illustration was created by @taniodraws.bsky.social our go-to freelance artist for summarizing our studies.

One limitation of our study is the use of rapidly dividing cells, where the protein homeostasis network likely differs from that in differentiated cells with lower protein production. Despite our efforts, we have yet to identify the E3 ligase involved—but we’re not giving up, so stay tuned!

In this case, the disease-associated mutation increases interaction with the DNAJA2 chaperone, which appear to be dispensable for the folding of the wild-type protein. This interaction delays the proteolysis of the mutant protein, potentially buffering its deleterious effects.

Using BioID, we identified chaperones, including the co-chaperone DNAJA2, that interact more with the unstable thiopurine S-methyltransferase (TPMT) variant than the wild type. DNAJA2 deletion accelerates degradation of the mutated TPMT but does not affect the wild-type protein

Many disease-associated mutations are missense mutations causing single amino acid changes that signal proteins for degradation. We surveyed 18 unstable variants from 13 cytosolic proteins and found that all but one are at least partially degraded via proteasome- and ubiquitin-dependent pathways.

Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published!
👇 Follow 🧵 for quick summary
journals.biologists.com/jcs/article-...

Congratulations to the whole team!

This PhD student helped to win a major pay hike for Canadian researchers Kaitlin Kharas is part of Nature’s 10, a list of people who shaped science in 2024.

CONGRATS to @supportourscience.bsky.social, Dr. Kaitlin Kharas, @sarahlaframboise.bsky.social & @cdrobich.bsky.social who were named "Nature's 10", a list of people who shaped science in 2024. #SupportOurScience achieved amazing things. The advocacy continues! www.nature.com/articles/d41...

Changes to the classification

ICYMI: Finland downgrades a bunch of Frontiers and MDPI journals to level 0.

julkaisufoorumi.fi/en/news/chan...

🤔 a lot of us will have to leave. Yes I am co-author on a MPDI journal 😬 But yeah if a see a lot of these journals in a CV, it will dampen my enthusiasm for an application

We first need to better educate our trainees about the issue (e.g. does your grad program cover the topic in a course?)

I would love to be added !

Thanks – who doesn't love to ride good vibes?!

P.S. I'm fine, just wanted to share this hiccup since we often tend to overemphasize our successes on SM

When I was on the bench It wasn't uncommon for experiments to fail, then fail again, and again (you probably know the feeling). A rejected grant is not that different

In most cases, it’s not the fall that matters but how we bounce back. Each trial makes us more experienced; well that’s the theory 😉

Failures in Science - I just received a negative decision on a grant proposal—my fifth in a row. It’s a though streak but not the first one, and I just wanted to share.

short 🧵👇

Advice for U.S. Government Scientists: Lessons Learned From the ‘Muzzling’ of Their Canadian Counterparts • The Revelator The next four years will be awful for the science and conservation community. By learning from past experiences, we can minimize the damage.

Will U.S. government scientists soon face the “muzzling” their Canadian counterparts experienced under right-wing Prime Minister Stephen Harper?

David Shiffman spoke to several people whose work was affected by Harper’s regressive policies, and they have advice to help prepare for Trump 2.0. ⬇️

Research Associate Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Johnson Laboratory | Department of Cellular and Physiological Sciences | Faculty of Medicine (James Johnson) Postin...

ubc.wd10.myworkdayjobs.com/en-US/ubcfac...

We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.

Makes sense - btw is SIFI still a RING ligase or we need to create RING-like category