Jim Hurley

Reconstitution of multistep recruitment of ULK1 to membranes in autophagy The ULK1 complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) act together to initiate autophagy. Human ULK1C consists of ULK1 itself, FIP200, and the HORMA domain het...

New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...

Membrane dynamics, repair and disease Keystone symposium this February in Colorado. The real, true, final abstract deadline is tonight so the organizers can start picking the short talks tomorrow! www.keystonesymposia.org/conferences/...

Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!

Compliance is a lot of work. Hats off to @doroteaartscience.bsky.social for her tireless efforts, and everyone in team @mito911.bsky.social .

Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...

Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...

Congratulations, Monther!

I just saw this in the NYT and now here- congratulations!

YouTube video by KeystoneSymposia KSQA: Dr. Dan Baird (Autophagy)

Early-career scientists - last call! ⏰ Submit your short talk abstract or scholarship app by Oct 8 (11:59 pm MDT) for Autophagy: Mechanisms to Therapy. Join @annesimonsen.bsky.social, Dan Baird & others!

🔗 keysym.us/KSAutophagy26
🎥 youtu.be/4Y6YvL-unAM

#KSAutophagy26 #autophagy #mitophagy

📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine.

👇 Reserve your spot using the link below.

📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

Structural basis for mTORC1 activation on the lysosomal membrane - Nature Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...

Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...

Thanks, Brett. @chen3dem.bsky.social did an incredible job, and everything came together.

RFK Jr. rolled out that old chestnut again about how healthy Americans were in the 60’s, so here’s a fact check.

In 1965:

-42% of American adults smoked; it’s 11% now.

-The infant morality rate was 24.7/1000; it’s 5.6/1000 now.

-Overall life expectancy was 70 years; it's about 77 years now.

Congratulations (even if it is hardly a surprise!)

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin.

👇 Reserve your spot using the link below.

📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc

🧪 And House appropriators say: no cuts to NIH budget!

House subcommittee version just came out (link below). Holds NIH flat at $48 billion.

To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.

YOUR VOICE MATTERS!!

BREAKING: Big moment as CDC staff stage a mass walkout.

They have lined the street outside its HQ to greet and salute the four top officials who have resigned in protest at RFK Jr’s attack on the agency’s science base.

(🎥 AP)

BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online:
aprecruit.berkeley.edu/JPF05098

So happy to see @doroteaartscience.bsky.social 's art on the cover!

New research reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy
www.nature.com/articles/s41...

Scared to. Googling them is bad enough.

nicht das Lysosom uber alles, das Lysosom ist alles

Love the bendy microtubule

Animal cell biology per gpt5:

Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...

Lysosomal membrane homeostasis and its importance in physiology and disease Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease