ArthurMageau

Comment le secteur 2, cet espace de « liberté tarifaire », s’est développé chez les médecins spécialistes En 2024, le montant total des dépassements d’honoraires a atteint 4,5 milliards d’euros, contre 3,5 milliards d’euros cinq ans plus tôt, selon l’Assurance-maladie, qui comptabilise 56 % de spécialiste...

www.lemonde.fr/societe/arti...

Humoral determinants of checkpoint immunotherapy - Nature Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.

Nature research paper: Humoral determinants of checkpoint immunotherapy

go.nature.com/41a8fin

Congratulations 👏👏 Ngoc and @elizabetharkema.bsky.social ! These data are important in helping us to select the most suitable immunosuppressant during pregnancy. #Medsky

Looking forward to future collaborations 🙂 🇸🇪🇺🇸🇻🇳🇫🇷 !

Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss | NEJM Two patients with monoclonal anti-PF4 antibodies, thrombosis, and chronic thrombocytopenia also had first-trimester pregnancy losses, findings that suggest a possible link between these antibodies ...

Two patients with monoclonal anti-PF4 antibodies, thrombosis, and chronic thrombocytopenia also had first-trimester pregnancy losses, findings that suggest a possible link between these antibodies and obstetrical complications. Read the full report: nej.md/4luAlx1

#MedSky #OBGYN

Anti‐ADAMTS13 Antibodies Trajectory is Associated With ADAMTS13 Recovery in Immune‐Mediated TTP Anti-ADAMTS13 IgG antibodies titer trajectory from baseline to day 7–14 post-TPE as a reliable approach to identify iTTP patients at risk of late response to the triplet therapy regimen.

Congratulations 👏👏 to @mimrobert.bsky.social for this very nice work 🗞
It seems worthy to look at anti-13 antibody during the follow-up of #iTTP . Maybe to guide anti-CD20 therapy ?
#Medsky
@amjh.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...

🌞 Un air d’été à l’hôpital Bichat – Claude-Bernard @ap-hp.bsky.social !
Ce midi, l’hôpital a célébré l’arrivée de l’été avec un déjeuner estival en musique, au jardin de la crèche du secteur Claude-Bernard 🎶🍔🌿

BCMA CAR T therapy to treat autoimmune cytopenias resistant to CD19 CAR T...🤯

Sounds like sci-fi but it is already there in @nejm.org !

Is this really the future of clinical immunology ?

Let's wait and find out !

Betw 2005 -2021, there was a substantial increase in HCQ use, but only modest steroid (GC) reductions. Swedish cohort study of 3891 SLE pts - over 5 yrs GC decr from 68% - 54% to 46%. HCQ increased by 29% over 5 years. buff.ly/7HudhKH

Subclinical atherosclerosis is associated with future cardiovascular events in lupus patients at apparent low cardiovascular risk - Arthur Mageau, Florence Arnoult, Marie-Paule Chauveheid, Thomas Papo... Objectives Prediction models based on traditional risk factors underestimate the risk for cardiovascular events (CVE) in SLE. We aimed to assess the occurrence ...

Looking for subliclinical atherosclerosis with vascular ultrasound could help us stratify the cardiovascular🩺 risk in #SLE #MedSky

@lupusjournal 🗞
@hopitalbichat.bsky.social 🏥

doi.org/10.1177/0961...

Key points of FcRn interactions in IgG-mediated therapies

Recently, a new class of therapeutics that disable the neonatal Fc receptor (FcRn), which protects IgG from degradation, has emerged to treat IgG-mediated autoimmune disease. Learn more in a new review: nej.md/42gEZYk

#MedSky #GastroSky

Human papillomavirus et lupus systémique : une revue systématique
www.sciencedirect.com/science/arti...
#SLE #HPV

Time‐dependent effect of prophylactic trimethoprim‐sulfamethoxazole on the incidence of serious infections in ANCA‐associated vasculitis: A target trial emulation study Objectives To investigate the effect of prophylactic trimethoprim-sulfamethoxazole (TMP-SMX) on the incidence of serious infections in patients with anti-neutrophil cytoplasmic antibody-associated v.....

An interesting design to test the prophylactic efficacy of 💊trimethoprin - sulfamethoxazole in #AAV
#Medsky

acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Temporal trends in glucocorticoids and hydroxychloroquine for treatment of systemic lupus erythematosus in Sweden AbstractObjectives. It is unknown to what extent updated treatment recommendations regarding glucocorticoids (GC) and hydroxychloroquine (HCQ) for patients

Congratulations 👏👏 to @AnnicaDominicus and @elizabetharkema.bsky.social for this useful work about temporal trends📉 in GC and HCQ for treatment of #SLE 🦋.

Are our practices in line with the evolution of treatment recommendations? Let's find out :

doi.org/10.1093/rheu...

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis | NEJM Giant-cell arteritis is a systemic vasculitis with limited treatment options. The efficacy and safety of upadacitinib — a selective Janus kinase (JAK) inhibitor that blocks the signaling of several...

We need safety 🦺 data regarding elderly patients with #GCA but this looks very interesting :

@nejm.org #Medsky

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis | New England Journal of Medicine www.nejm.org/doi/full/10....

Figure 1. Iron Absorption, Storage, and Conservation in the Body

Absolute iron deficiency affects approximately 2 billion people worldwide.

This narrative review examines the screening, diagnosis, and treatment of adults with absolute iron deficiency without anemia and iron-deficiency anemia.

#ACC25 https://ja.ma/3Xw1i9K

Baricitinib in early polymyalgia rheumatica (BACHELOR): a randomised, double-blind, placebo-controlled, parallel-group trial This study suggests that, compared with placebo, individuals with polymyalgia rheumatica receiving 4 mg baricitinib are less likely to need oral glucocorticoids to have low disease activity at week 12...

Treating polymyalgia rheumatica with baracitinib but without oral glucocorticoids ? #MedSky

Interesting 🇫🇷 findings 🗞 @thelancetrheum.bsky.social

www.thelancet.com/journals/lan...

J&J announced the FDA jas granted the investigational drug, nipocalimab (FcRn recpt Ab), with Fast Track designation for its study in adult patients with moderate-to-severe Sjögren’s disease buff.ly/SFYky98

Tolerance for uncertainty and medical students' specialty choices: A myth revisited Background In 1962, the idea emerged that medical students' tolerance of uncertainty could determine their specialty choice. While some studies supported this claim, others refuted it, often using i...

Does tolerance for uncertainty 🤷 affect medical students' specialty choice ? #Medsky @medicaleducation.bsky.social
I used to think that internal medicine or emergency medicine physicians had a better tolerance than others...

asmepublications.onlinelibrary.wiley.com/doi/10.1111/...

Mizoribine or Cyclophosphamide for Lupus Nephritis This randomized clinical trial assesses the efficacy and safety of oral mizoribine vs intravenous cyclophosphamide as induction therapy for lupus nephritis among Chinese patients.

An old new immunosuppressant 💊 for lupus nephritis ? Mizoribine vs CYC in this original study #MedSky @jama.com . In the era of Mabs, it is quite unexpected !

jamanetwork.com/journals/jam...

Population-Scale Studies of Protein S Abnormalities and Thrombosis This cross-sectional study evaluates the risk associated with protein S deficiency across multiple arterial thrombosis phenotypes in population-level cohorts.

Rare PROS1 variants significantly increase venous thromboembolism risk, revealing low protein S as a key factor in thrombotic disorders.

by Chaudhry SA, Haj AK (...) Bendapudi PK et 9 al. in JAMA #MedSky

📖 read the article:

Could we use serum type I interferon score for prediction of disease progression in limited cutaneous systemic sclerosis ? Retrospective data look convincing enven if they need to be reproduced in a different setting. #Medsky

📰:
acrjournals.onlinelibrary.wiley.com/share/UNQCUF...

What are the clinical presentation and outcomes of adult patients with immune mediated inflammatory disease who were hospitalised following an ED referral 🚑 ? Find out in this study from @ElisaChapuis 👏 #MedSky @hopitalbichat.bsky.social
rdcu.be/eb54T

L’Ordre des médecins, un gendarme professionnel régulièrement accusé de corporatisme et de conservatisme L’Ordre des médecins, mis en cause pour son attitude face au chirurgien pédocriminel Joël Le Scouarnec, est chargé d’assurer la discipline dans la profession médicale. Il est régulièrement accusé d’av...

"L’Ordre des médecins, mis en cause pour son attitude face au chirurgien pédocriminel Joël Le Scouarnec, est chargé d’assurer la discipline dans la profession médicale. Il est régulièrement accusé d’avoir une approche corporatiste et conservatrice."
www.lanouvellerepublique.fr/a-la-une/l-o...

Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren’s disease Objectives Sjögren’s disease (SD) is an autoimmune disease affecting the exocrine glands that is associated with autoantibodies against Ro60/SS-A, anti-Ro52/TRIM21, La/SS-B and others. We examined the...

Some interesting and original insights into the complex relationship between EBV 🦠 and autoimmunity 😷
ard.bmj.com/content/earl...

Faecal microbiota transplantation in patients with systemic sclerosis and lower gastrointestinal tract symptoms in Norway (ReSScue): a phase 2, randomised, double-blind, placebo-controlled trial Faecal microbiota transplantation with ACHIM was well tolerated in participants with systemic sclerosis but did not result in an improvement in lower gastrointestinal tract symptoms.

Another disappointment for the use of microbiota tansplantation in autoimmune disease, here in #SSc @thelancet.bsky.social Will it have any indication in clinical practice ? #MedSky
www.thelancet.com/journals/lan...

Pas une ride

Interesting Swedish data #ki about the assocation of infection burden with Kawasaki dz.
"Differents agents may induce the disease" authors say. 🗞
It would be so interesting to understand the immune mechanisms behind this non-specific post-infection autoimmunity.
rmdopen.bmj.com/content/11/1...

Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. https://buff.ly/4hRGpOb
#OpenAccess

Procès Le Scouarnec : comment l’ex-chirurgien pédocriminel aux 299 victimes est si longtemps « passé entre les gouttes » La plus importante affaire de pédocriminalité jugée en France débute à partir de lundi et pour quatre mois. Age moyen des victimes : 11 ans à l’époque des faits. Des crimes que l’accusé racontait méth...

Encore une bonne raison de dissoudre l'ordre des médecins ! Comment peut-on encore supporter cette institution inutile et défaillante ?

www.lemonde.fr/societe/arti...

Allogeneic CAR T Cell Products Cemacabtagene Ansegedleucel/ALLO-501 in Relapsed/Refractory Large B-Cell Lymphoma: Phase 1 Experience From the ALPHA2/ALPHA Clinical Studies PurposeOff-the-shelf, allogeneic CD19 chimeric antigen receptor (CAR) T cell products may improve access to treatment versus autologous ones. We report the phase 1 experience of the allogeneic CD19 CA...

Les CAR T allogéniques commencent à montrer des résultats intéressants dans le traitement des DLBCL:
ascopubs.org/doi/10.1200/...

Il y aura-t-il bientôt une place pour ces traitements en immuno clinique ? Quel avantage par rapport au CAR T autologues dans ces situations ?