@vasculitides

Behçet's Disease Presenting With Large Intracavitary Thrombi and Pulmonary Embolism - PubMed Behçet's disease (BD) is a rare chronic multisystem inflammatory disorder characterized by recurrent mucocutaneous, ocular, musculoskeletal, and vascular manifestations. Although vascular involvement is common, cardiac manifestations are exceptionally rare and can be life-threatening. We report a un …

Behcet's Disease Presenting With Large Intracavitary Thrombi and Pulmonary Embolism

Tavneos combo works as well as steroids for AAV remission in trial A Tavneos combination was similarly effective, with fewer side effects, to one with corticosteroids for ANCA-associated vasculitis remission.

Tavneos combo works as well as steroids for AAV remission

You Never Think Enough About Giant Cell Arteritis - PubMed If PAMM and negative CRP are frequently encountered in "cranial GCA," "aortoarteritic GCA" is usually associated with inflammatory signs, which was not the case in this patient, reminding us that a high degree of suspicion should always be maintained in case of PAMM in elderly patients.

You Never Think Enough About Giant Cell Arteritis

Addressing clinical challenges in ANCA-associated vasculitis with real-world evidence - PubMed Key challenges in the management of anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) include the need to achieve more rapid and sustained remission, reduce exposure to glucocorticoids (GC), and reliably monitor and predict treatment response. Clinical trials in patients rece …

Addressing clinical challenges in ANCA-associated vasculitis with real-world evidence

METTL3-mediated m6A Methylation Modification Promotes the Endothelial Cell Pyroptosis in Kawasaki Disease - PubMed Kawasaki disease (KD) is classified as an acute febrile illness characterized primarily by systemic vasculitis. While the involvement of N6-methyladenosine (m⁶A) modification in various cardiovascular conditions has been established, its specific role in KD remains unexplored. This study …

METTL3-mediated m(6)A Methylation Modification Promotes the Endothelial Cell Pyroptosis in Kawasaki Disease

Boom or Bust: Clinical Trials in Pemphigus and Other B-Cell-Mediated Autoimmune Diseases - PubMed Pemphigus vulgaris (PV) is a B-cell-mediated autoimmune blistering disease characterized by autoantibodies targeting skin cell adhesion proteins. Despite the well-defined pathophysiology and unmet need for safe and effective therapies for pemphigus, multiple therapeutics have failed to advance throu …

Boom or Bust: Clinical Trials in Pemphigus and Other B-Cell-Mediated Autoimmune Diseases

Central Nervous System Vasculitis Due to Ehrlichia canis in a Dog - PubMed A 4-year-old female neutered crossbreed dog was presented for a 2-month history of intermittent vestibulo-cerebellar ataxia and right head tilt. On admission, she presented clinical signs compatible with right paradoxical vestibular syndrome. Haematology showed moderate lymphocytosis, thrombocytopen …

Central Nervous System Vasculitis Due to Ehrlichia canis in a Dog

A Case Report of Bilateral Sequential Central Retinal Artery Occlusion in Occult Giant Cell Arteritis: The Eyes Are Windows to Systemic Disease - PubMed Giant cell arteritis (GCA) is an inflammatory condition generally affecting medium to large arteries, commonly affecting the carotid artery and its branches. GCA generally presents with systemic symptoms such as temporal headache, jaw claudication, and polymyalgia rheumatica. Occult GCA is a variant …

A Case Report of Bilateral Sequential Central Retinal Artery Occlusion in Occult Giant Cell Arteritis: The Eyes Are Windows to Systemic Disease

Correction: A Case of Takayasu's Arteritis Presenting With Acute Middle Cerebral Artery Stroke Managed With Aortic-Common Carotid Artery (CCA) Bypass Surgery - PubMed [This corrects the article DOI: 10.7759/cureus.48166.].

Correction: A Case of Takayasu's Arteritis Presenting With Acute Middle Cerebral Artery Stroke Managed With Aortic-Common Carotid Artery (CCA) Bypass Surgery

Takayasu arteritis presenting with severe biventricular dysfunction and renal artery stenosis in a pediatric patient: a case report - PubMed Pediatric TA with multi-organ involvement requires a coordinated, multidisciplinary approach for optimal outcomes. This case exemplifies the complexities of managing refractory hypertension and advanced vascular complications in TA and emphasizes the critical role of advanced interventional techniqu …

Takayasu arteritis presenting with severe biventricular dysfunction and renal artery stenosis in a pediatric patient: a case report

Role of multimodal monitoring in the anesthetic management of a patient with Takayasu's arteritis for neurosurgery - PubMed Role of multimodal monitoring in the anesthetic management of a patient with Takayasu's arteritis for neurosurgery

Role of multimodal monitoring in the anesthetic management of a patient with Takayasu's arteritis for neurosurgery

Kawasaki disease complicated with shock syndrome and macrophage activation syndrome in children: a case report - PubMed Kawasaki disease (KD) is an acute self-limited vasculitis of unknown etiology. Clinically, a small proportion of patients may develop shock syndrome or macrophage activation syndrome (MAS); however, KD shock syndrome (KDSS) complicated by MAS is extremely rare. This article provides a detailed repor …

Kawasaki disease complicated with shock syndrome and macrophage activation syndrome in children: a case report

Intralesional rituximab injections for orbital granulomatosis with polyangiitis: a case series and literature review - PubMed Rituximab, an anti-CD-20 monoclonal antibody, has garnered increasing interest as a therapeutic option in orbital inflammatory disease (OID). We report our institutional experience with intralesional rituximab injections in two cases of orbital granulomatosis with polyangiitis (GPA), and additionall …

Intralesional rituximab injections for orbital granulomatosis with polyangiitis: a case series and literature review

Rapidly progressive anti-GBM disease secondary to long-standing rheumatoid arthritis: a case report and literature review - PubMed This case highlights the need for early serological testing for anti-GBM disease in RA patients with unexplained hematuria/proteinuria and for immunosuppressive therapy mindful of infection risk. Additionally, our literature review identified only ten reported cases of RA with anti-GBM disease, high …

Rapidly progressive anti-GBM disease secondary to long-standing rheumatoid arthritis: a case report and literature review

Immune cell crosstalk between ANCA-associated vasculitis and IgG4-related disease: an unresolved pathogenic link - PubMed Immunoglobulin G4-related disease (IgG4-RD) is a rare, multisystemic fibro-inflammatory condition affecting various organs, including kidneys, lungs, nasal cavity, pancreas, salivary glands, and orbit. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAVs) is a multi-systemic infla …

Immune cell crosstalk between ANCA-associated vasculitis and IgG4-related disease: an unresolved pathogenic link

Comparison between primary and secondary central nervous system vasculitis in terms of clinical, biochemical, radiological, histopathological features, and outcomes: a single-center retrospective cohort study - PubMed In our study, PACNS patients presented more often with pseudotumoral lesions, seizures and small-vessel involvement and lymphocytic histologic pattern. WBC count ≤9.93×10³/mm³ was an independent predictor of PACNS diagnosis.

Comparison between primary and secondary central nervous system vasculitis in terms of clinical, biochemical, radiological, histopathological features, and outcomes: a single-center retrospective cohort study

Choroidal thickness as a biomarker of systemic inflammation in patients with polymyalgia rheumatica - PubMed We found that CT was high in patients with recent diagnosis of PMR and decreases significantly after 3 and 6 months of corticosteroid therapy. There is a 95% of concordance between CT and CRP as well as between CT and PMR activity scores. Our findings suggest that CT is useful as a noninvasive, imag …

Choroidal thickness as a biomarker of systemic inflammation in patients with polymyalgia rheumatica

Rapidly progressive relapsing polychondritis following surgery for lung adenocarcinoma: a case report - PubMed This case highlights the rare temporal correlation of RP as a paraneoplastic syndrome that can occur prior to or concurrently with tumor onset, but it may also arise following tumor resection. Because of the rarity and adverse consequences of RP, clinicians should improve their recognition of the di …

Rapidly progressive relapsing polychondritis following surgery for lung adenocarcinoma: a case report

Immunosuppression and Surgery-Free Interval in Granulomatosis With Polyangiitis Airway Stenosis - PubMed Rituximab may contribute to longer intervals between endoscopic airway intervention and delay relapse in GPA-related airway stenosis, supporting its role in stabilization of airway manifestations. Multidisciplinary management remains essential for this life-threatening GPA manifestation.

Immunosuppression and Surgery-Free Interval in Granulomatosis With Polyangiitis Airway Stenosis

Long-term effectiveness and safety of benralizumab in EGPA: a 3-year single-center experience - PubMed These findings support the long-term effectiveness and safety of benralizumab for EGPA, highlighting its role in inducing clinical remission, reducing corticosteroid dependence, and controlling disease activity.

Long-term effectiveness and safety of benralizumab in EGPA: a 3-year single-center experience

Anticoagulation-free VV-ECMO for a child with intractable pulmonary hemorrhage: A case report - PubMed IntroductionSystemic anticoagulation (AC) is standard practice in extracorporeal membrane oxygenation (ECMO). Adults on ECMO have been successfully managed AC-free. However, slower flow rates in pediatric circuits have mostly prevented this strategy. Thus, ECMO is often avoided in children with intr …

Anticoagulation-free VV-ECMO for a child with intractable pulmonary hemorrhage: A case report

From Silicone to Synovitis: Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) in Behçet's Disease - PubMed From Silicone to Synovitis: Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) in Behçet's Disease

From Silicone to Synovitis: Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) in Behcet's Disease

The clinical management of adult patients with Familial Mediterranean fever - PubMed The possibility of occurrence of FMF is not completely excluded in adult patients, despite it could be characterized by atypical or delayed-onset presentations. Thus, raising the awareness toward the disease is of critical importance in improving the outcome of these patients.

The clinical management of adult patients with Familial Mediterranean fever

PPI Use and Its Significant Association With an Increased Incidence of Intestinal Behçet Disease - PubMed PPI Use and Its Significant Association With an Increased Incidence of Intestinal Behçet Disease

PPI Use and Its Significant Association With an Increased Incidence of Intestinal Behcet Disease

Development of Successive Thrombophlebitis and Takayasu Arteritis Associated With Crohn Disease in a Pediatric Patient: A Case Report - PubMed Development of Successive Thrombophlebitis and Takayasu Arteritis Associated With Crohn Disease in a Pediatric Patient: A Case Report

Development of Successive Thrombophlebitis and Takayasu Arteritis Associated With Crohn Disease in a Pediatric Patient: A Case Report

Living with Eosinophilic Granulomatosis with Polyangiitis (EGPA): Podcast of a Patient-Physician Discussion - PubMed For people living with eosinophilic granulomatosis with polyangiitis (EGPA), the journey to diagnosis can be long and complicated. EGPA is a rare inflammatory disorder, typically characterized by high levels of blood eosinophils and vasculitis in the lungs and/or other end organ(s). It is associated …

Living with Eosinophilic Granulomatosis with Polyangiitis (EGPA): Podcast of a Patient-Physician Discussion

Gastrointestinal involvement in granulomatosis with polyangiitis: frequency, clinical impact, and prognostic implications in a retrospective cohort study - PubMed Gastrointestinal involvement in GPA is associated with more severe disease activity, diminished treatment response, and increased mortality. Early detection and appropriate management of GI manifestations may improve clinical outcomes. Further prospective studies are warranted to elucidate the under …

Gastrointestinal involvement in granulomatosis with polyangiitis: frequency, clinical impact, and prognostic implications in a retrospective cohort study

Low-dose interleukin-2 in the treatment of refractory relapsing polychondritis - PubMed Low-dose interleukin-2 in the treatment of refractory relapsing polychondritis

Low-dose interleukin-2 in the treatment of refractory relapsing polychondritis

Recurrent Left Main Occlusion in Pediatric Kawasaki Disease: Surgical Patch Angioplasty With Autologous Pulmonary Trunk - PubMed SPA using autologous pulmonary artery offers a potentially advantageous alternative for coronary reconstruction in small children, particularly in cases of isolated proximal coronary stenosis or where traditional CABG may be technically challenging or unsustainable owing to small conduit caliber.

Recurrent Left Main Occlusion in Pediatric Kawasaki Disease: Surgical Patch Angioplasty With Autologous Pulmonary Trunk

From symptom amelioration to function modification: is it time to expand the treatment focus in polymyalgia rheumatica? - PubMed From symptom amelioration to function modification: is it time to expand the treatment focus in polymyalgia rheumatica?

From symptom amelioration to function modification: is it time to expand the treatment focus in polymyalgia rheumatica?