Mathieu Dedenon

If you’ve been following this account closely, you might already know methods to probe mechanics in vitro, but what about in live embryos?

I’m @amichaut.bsky.social, and I’m going to share a few great papers on this aspect of #EpithelialMechanics.

An active torque dipole across tissue layers drives avian left-right symmetry breaking Unlike in mice, frogs, and fish, left-right (L/R) body axis formation in avian embryos does not arise from the chiral beat of cilia. Instead, a counter-clockwise tissue rotation around Hensen′ node, t...

(1/10)
I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me.
doi.org/10.1101/2025...

So excited to share my 1st paper !!🌞
Co-authored with @jules-vanaret.bsky.social @dunsingvalentin.bsky.social, we developped an integrated pipeline for imaging, segmenting and analysing cell-scale patterns in gene expression + tissue properties in complex 3D tissues
elifesciences.org/reviewed-pre...

Michaut, A., Chamolly, A., Alegria-Prévot, O., Phan, C., Corson, F., & Gros, J. (2025). Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis. bioRxiv, 2025-05. #EpithelialMechanics doi.org/10.1101/2025...

Morphogen gradients are regulated by porous media characteristics of the developing tissue Summary: Image-based 3D modeling of pore-scale extracellular space geometries of the developing zebrafish embryo reveals that the Fgf8a morphogen gradient is regulated by the porous media characterist...

⚡️Advanced Computing ❤️ laboratory experiments ➡️ an unbeatable combination to unlock the secrets of biology! Together with the Brand lab @tudresden.bsky.social we @csbdresden.bsky.social discovered a simple mechanism how tissue geometry controls growth: journals.biologists.com/dev/article/...

Hi I’m @yamini-ravichan.bsky.social , a postdoc interested in the mechanical induction of topological defect-mediated morphogenesis. I use different organisms to study the role of topological defects shaping development & regeneration. Below is an insight to the field!

Physics meets fashion: a bioluminescent dress A very special look was presented earlier this week by fashion designer Iris van Herpen at the Paris Haute Couture Week. The garment: a bioluminescent dress, created from 125 million living algae. Bio...

In the last couple of months I helped biodesigner Chris Bellamy in a collaboration with fashion designer Iris van Herpen to make a bioluminescent dress for Paris Haute Couture week.

And the outcome was absolutely stunning!!!!

www.uva.nl/en/shared-co...

YouTube video by Roux Lab - University of Geneva Cell forces, order and flows during In vitro reconstitution of morphogenesis

Nice discussions after the talk given online yesterday at cytophys.org, presenting the work of @pauguillamat.bsky.social @clairedessalles.bsky.social @yamini-ravichan.bsky.social @oriolmb.bsky.social and Tithi Mandal. Available on the lab youtube channel at:
youtu.be/g-7HomnPdtk

Krishna, S., Gopinath, A., & Bhattacharjee, S. M. (2022). Ordering and topological defects in social wasps' nests. Scientific reports, 12(1), 12901. #EpithelialMechanics www.nature.com/articles/s41...

SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...

Ravichandran, Y., Vogg, M., Kruse, K., Pearce, D. J., & Roux, A. (2025). Topology changes of Hydra define actin orientation defects as organizers of morphogenesis. Science Advances, #EpithelialMechanics www.science.org/doi/10.1126/...

A multicellular star-shaped actin network underpins epithelial organization and connectivity - Nature Communications The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...

Ever wished to become an actin star? 😎
Then try getting suspended above a non-adhesive substrate.
www.nature.com/articles/s41...

🚨 Join us tomorrow for this really exciting talk on the interplay between morphogen signalling and tissue organization! 🚨

New paper from the lab led by @marija-matejcic.bsky.social ! Supracellular force patterns driving intestinal cell extrusion. 👇

Guillamat, P., Blanch-Mercader, C., Pernollet, G., Kruse, K., & Roux, A. (2022). Integer topological defects organize stresses driving tissue morphogenesis. Nature materials, 21(5), 588–597. #EpithelialMechanics www.nature.com/articles/s41...

Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).

Please apply and/or repost!

jobs.unige.ch/www/wd_porta...

"Extrusion on the villus even without curvature"
Wow crazy !!
Very interesting 🤔
Beautiful work 👏🤩

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

🚨 Second preprint of the week!

We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.

We harness these mechanical instabilities for synthetic morphogenesis.

Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu

www.biorxiv.org/content/10.1...

Congratulations Nimesh and all co-authors, fantastic work 😍🤩👏

Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling

Beautiful work, very interesting ! 🤩
Congratulations to all ! 👏

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos Nature Communications - The morphogenetic events that occur during gastrulation involve dramatic cell- and tissue-level changes. Here they show that propagation of nematic order, leading to...

Scientific collaborations come in many flavors & are fun because they expose you to new areas of science. That was definitely the case for this paper, out today. We were definitely in the passenger seat but it was fun to go along for the ride 1/n
rdcu.be/euiZB.

How to turn a layer of fibroblasts into a tulip 🌷?

Check out our new pre-print on shape-programmable living surfaces.

Led by @pauguillamat.bsky.social‬

www.biorxiv.org/content/10.1...

Pigment cell movement is not required for generation of Turing patterns in zebrafish skin - Nature Communications Pigment pattern formation in zebrafish depends on the interactions between the pigment cells. Here the authors present a mathematical model based on mutual interaction of pigment cells in the absence ...

I worked on a group project that created a toy agent-based model simulating interactions between cells to form patterns. This project was inspired by a study on stripe formation in zebrafish, showing how simple cell interactions produce beautiful patterns in nature. www.nature.com/articles/nco...

Nanavati, B. N., Noordstra, I., ..., Green, K. J., & Yap, A. S. (2024). The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis. Current biology : CB, 34(17), 4081–4090.e5. #EpithelialMechanics
buff.ly/MI1S7wP

www.biorxiv.org/content/10.1...

Congratulations Pau, looks amazing !! 🤩👏

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.

The tissue morphogenesis logic, now engineered into living, programmable materials.

www.biorxiv.org/content/10.1...

#ActiveMatter #TissueEngineering

Epithelial morphogenesis is all about how epithelial tissues develop unique shapes and structures! I'm @nehaghosh.bsky.social and will share some research in this area.