Alfred Fischer

Cryotherapy Alternative to Lumpectomy Wins FDA Marketing Nod For some older women with early breast cancer, lumpectomy may no longer be necessary.

An alternative to classical surgery in breast cancer.

#cryotherapy

www.medscape.com/viewarticle/...

Gedatolisib was tested with palbociclib in a phase Ib study.

#breastcancer

aacrjournals.org/clincancerre...

To switch the CDK In in second line helps.

#breastcancer

t.co/le0TNbSehV

Epidemiological development of breast cancer in the USA.

Link.

breast-cancer-research.biomedcentral.com/articles/10....

Die Imago des Schmetterlings lebt oft nicht lange. Ist oft so

Haben sich eh aufgelehnt. Siehe die großen Revolutionen. Brauchte seine Zeit.

Breast Cancer Awareness Month

Previous data suggest synergy between PARP inhibition and immune checkpoint blockade in different genetic settings.

Here a phase II trial in HR+/HER2- patients.

aacrjournals.org/clincancerre...

Aspirin Use and Risk of Breast Cancer Recurrence in Chinese Patients - PubMed Background Observational studies have suggested a potential role for aspirin in reducing breast cancer recurrence, but data from Asian populations remain limited. We aimed to evaluate the association ...

Among Chinese women with breast cancer, long-term aspirin use was associated with improved IDFS.

#oncology #epidemiology

pubmed.ncbi.nlm.nih.gov/40986335/

Masculinizing Testosterone Therapy Reduces the Incidence of PIK3CA-Mutant/ER⁺ Breast Cancer but Not BRCA1-Associated Triple-Negative Breast Cancer - PubMed TT reduces ER+ BC risk but does not eliminate risk, and has a negligible impact on <i>BRCA1</i> -related triple-negative BC risk. TT does not affect tumor growth once tumors are established but modula...

Testosterone therapy decreases PIK3CA -related ER+ breast cancer incidence by 81% in mice.

pubmed.ncbi.nlm.nih.gov/41001463/

Vitamin B12 Cuts Risk for Chemotherapy Hand-Foot Syndrome Oral vitamin B12 halves the rate of moderate-to-severe capecitabine-induced hand-foot syndrome in patients with breast cancer.

www.medscape.com/viewarticle/...

Ribociclib Shows Lasting Benefit in Early Breast Cancer Researchers examined invasive disease-free survival rates at 4 years in a randomized phase 3 trial of adjuvant treatment for women and men with HR+/ERBB2-negative early breast cancer.

Kisqali highly effective in early breast cancer.

www.medscape.com/viewarticle/...

The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...

ALASCCA Trial Results: Low-Dose Aspirin in PI3K-Altered CRC - OncoDaily ALASCCA trial: Low-dose aspirin after surgery nearly halves recurrence in PI3K-mutated colorectal cancer, reflected in NCCN 2025 guidelines.

ALASCCA Trial Results: Low-Dose Aspirin in PI3K-Altered CRC

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ALASCCA #Aspirin #CRC #GIOnc #ColorectalCancer

Olanzapine alleviates anorexia and improves QoL in incurable cancer with cachexia.

jnccn.org/view/journal...

The New England Journal of Medicine Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer A Research Summary based on Martling A et al. | 10.1056/NEJMoa2504650 | Published on September 18, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In patients with localized colorectal cancer and PIK3CA hotspot mutations in exon 9 or 20, daily low-dose aspirin resulted in a significantly lower recurrence rate than placebo. Full ALASCCA phase 3 trial results and Research Summary: nej.md/4mpKXNp

#MedSky #Oncology

ESR1 Expression Negatively Correlates with Immune Cell Infiltration and Response to Immune Checkpoint Inhibitors in Estrogen Receptor-Positive/HER2-Negative Breast Cancer - PubMed High ESR1 expression was associated with an immunosuppressive TME in ER+/HER2- BC and is a more robust predictive biomarker for ICI response in this BC subtype.

Yet another explanation why HR+/HER2- breast cancer does not respond well to immune checkpoint inhibitors.

#cancer #oncology #pembrolizumab #esr1

pubmed.ncbi.nlm.nih.gov/40956534/

Impact of Screening Mammography on Breast Cancer Outcomes in Women Aged 80 Years and Over - PubMed Breast cancer patients diagnosed at ≥ 80 years of age who received screening mammography presented with earlier-stage disease and had improved DFS and OS compared with the unscreened cohort.

Women over 80 also benefit from mammography!

#screening #cancer #oncology #breastcancer

pubmed.ncbi.nlm.nih.gov/40946125/

Nicotinamide for Skin Cancer Chemoprevention This cohort study examines the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.

Study shows that patients taking nicotinamide 500 mg twice daily can significantly reduce their risk for skin cancer.

jamanetwork.com/journals/jam...

Patient-Reported Outcomes as Prognostic Indicators for Overall Survival in Cancer This systematic review and meta-analysis evaluates the association between baseline patient-reported outcomes and overall survival in patients with cancer.

Was to be expected…

Nausea and vomiting, fatigue, and pain were all associated with worse overall survival.

#oncology #cancer

jamanetwork.com/journals/jam...

Concomitant Comedications and Survival With First-Line Pembrolizumab in NSCLC This cohort study using a target trial emulation approach examines associations of comedications (antibiotics, steroids, and proton pump inhibitors) with survival among patients in France with non–sma...

Certain proton pump inhibitors, steroids, and antibiotics were associated with worse overall survival with Pembrolizumab.

#oncology #lungcancer

jamanetwork.com/journals/jam...

Due to bleeding, the visual prognosis is poor, especially in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML).

t.co/B0LNQLO47h

Weekend Warrior Physical Activity Cuts Lung Cancer Risk Moderate-to-vigorous physical activity performed over 1-2 days or regularly is linked to a reduced risk for lung cancer and has no effect on prostate, breast, or colorectal cancer, a study shows.

Exercising only on weekends minimizes the risk of lung cancer.

#oncology #cancer #epidemiology

www.medscape.com/viewarticle/...

The concept of dormant tumor cells (DTCs) has been around for some time in oncology, especially in breast cancer.

Remember @MichaelGnant and the ABCSG12 study.

Now there are new approaches using everolimus, among others.

t.co/WShkGgLfGv

Serum ferritin levels were associated with decreased risk of breast cancer in premenopausal, but not in postmenopausal women.

aacrjournals.org/cebp/article...

Alcohol consumption is an important contributor to cancer incidence.

The largest increase in overall alcohol-attributable cancer rates were for breast cancer among women.

aacrjournals.org/cebp/article...

Podcast about Maple syrup.

podcasts.apple.com/at/podcast/t...

Association of eating duration less than 8 h with all-cause, cardiovascular, and cancer mortality To assess the association between eating duration less than 8 h and all-cause and cause-specific mortality.Adult participants who reported usual intak…

Some studies confirm health benefits of intermittent fasting, but long-term studies are lacking, and a new study even sees an increased risk of cardiovascular disease.

www.sciencedirect.com/science/arti...

Bumblebee on the rocks: Massive aggregation, migratory and climbing behaviour of a small Neotropical catfish Rhyacoglanis are small catfish species of the family Pseudopimelodidae, Siluriformes, commonly known as bumblebee catfishes. Despite their broad distribution, the species are rare, and little is know....

Brazilian scientists have documented a fascinating phenomenon.
Thousands of small catfish (Rhyacoglanis paranensis) climbed a meter-high waterfall.
Suction cups on their bellies allow them to cling to the wet rocks.

Link to the study:

onlinelibrary.wiley.com/doi/10.1111/...