Jamie Walker, MD, PhD

Patient can’t look up or down. What’s going on?

31.12.2024 16:35 — 👍 4    🔁 1    💬 2    📌 0

PSP?

31.12.2024 17:12 — 👍 1    🔁 0    💬 1    📌 0

However, there are differences in protein expression between PART and CTE in the hippocampus, including NeuN which is high in definite PART but low in CTE, certain microglial markers, and some proteins involved in response to oxidative stress or mitochondrial damage.

31.12.2024 14:23 — 👍 0    🔁 0    💬 0    📌 0

We found that PART and CTE display several similarities in protein expression that are distinct from AD, perhaps in relation to lower levels of beta-amyloid … which could be secondary to the maintenance of expression of proteins involved in proteostasis and beta-amyloid processing.

31.12.2024 14:22 — 👍 0    🔁 0    💬 1    📌 0

Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age‐related tauopathy hippocampi INTRODUCTION Alzheimer's disease (AD), primary age-related tauopathy (PART), and chronic traumatic encephalopathy (CTE) all feature hyperphosphorylated tau (p-tau)–immunoreactive neurofibrillary deg...

AD, PART and CTE share the same 3R/4R-tau+ NFTs, but in a different distribution … what about their proteomes? Excited to share our spatial proteomics study comparing #Alzheimers, #PART and #CTE hippocampi doi.org/10.1002/alz....
#neuropath #neuroscience #neurology #proteomics

31.12.2024 14:21 — 👍 11    🔁 2    💬 1    📌 0

This is a spinal cord anterior horn motor neuron … do you see what 👁️see? #neuropath #neuroskyence

17.12.2024 20:34 — 👍 4    🔁 1    💬 0    📌 0

Brains of Alzheimer's patients—but look at the other aggregated proteins! We explore how two distinct variants of αSynuclein co-pathology contribute to hippocampal degeneration. Check out our new article in @braincomms.bsky.social: academic.oup.com/braincomms/a... 🧠🧪

14.12.2024 09:47 — 👍 5    🔁 2    💬 1    📌 0

Here’s a pineal gland, named after the pine cone! Did you know Descartes thought the pineal was the seat of the soul? www.neurology.org/doi/10.1212/...
The brain is cut in the axial plane here. What other structures can you identify? Happy Holidays! #neuroskyence #neuropath #neurology #neuroanatomy

13.12.2024 00:05 — 👍 21    🔁 3    💬 0    📌 0

Method of the Year 2024: spatial proteomics - Nature Methods Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

06.12.2024 20:52 — 👍 618    🔁 172    💬 3    📌 18

🙋‍♀️

23.11.2024 03:46 — 👍 0    🔁 0    💬 0    📌 0

Awh, cool!! Yes, some are from bakerlogy!

23.11.2024 03:32 — 👍 0    🔁 0    💬 0    📌 0

Got some new cookie cutters … the heart and the coronal section! Can you guess any of the diagnoses? #neuropath #neuroscience #neuroskyence

22.11.2024 18:55 — 👍 19    🔁 3    💬 2    📌 1

Morphology of Memory: The Anatomy of the Human Hippocampus The hippocampus is a part of the brain known to be critical for learning and memory. It is made up of many interconnected regions with distinct characteristics.…

Fantastic explanation of the anatomy of the human #Hippocampus! Great video and visualizations!👌 #neuroscience #PsychSciSky vimeo.com/323365182

17.11.2024 15:00 — 👍 249    🔁 63    💬 12    📌 10

🙋‍♀️

16.11.2024 18:51 — 👍 2    🔁 0    💬 0    📌 0

Check out this cool #hippocampus with what appears to be hippocampal sclerosis. #neuropath

14.11.2024 12:49 — 👍 3    🔁 0    💬 0    📌 0