Jeremy Yap

Blood cancer: a treatment to reprogram cancer cell death and trigger the immune system The aim of immunotherapy strategies is to leverage cells in the patient's own immune system to destroy tumor cells. Using a preclinical model, scientists from the Institut Pasteur and Inserm successfu...

Blood cancer: reprogramming cell death to awaken immunity.

Institut Pasteur & Inserm scientists show that forcing malignant B cells into necroptosis triggers a powerful anti‑tumor response. A triple‑therapy strategy clears leukemia in preclinical models.

👉 www.pasteur.fr/en/press-are...

Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity A central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are …

Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological data from two large human cohorts.

Viral infections can wake up dormant breast cancer cells in the lung, driving metastasis

www.nature.com/articles/s41...

Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...

New #flowcytometery protocol drop from Oliver Burton.

This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

(1/3) 🚨 We’re back with Edition #2 of our 2025 International Cell Death Seminar Series! 🚨
📅 Wednesday 3 Sept | 🦘 4:30pm AEST / 🌍 8:30am CEST
In collaboration with @ecdoorg.bsky.social + @CDDpress.
Flyer below ⬇️

#ACDS #CellDeath

This is figure 2 showing how SNAP-tag engineering is aiming for faster and brighter fluorescence labeling

SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!

www.embopress.org/doi/full/10....

🚨 Applications for the 2025 ACDS Professional Development Award close soon!
Don't miss your chance to secure $2,000 for travel or training.

🗓️ Deadline: 5pm AEST, Friday 6 June
📩 Apply now: australasiancelldeathsociety.com/acds-awards

#celldeathresearch #careerdevelopment | Australasian Cell Death Society (ACDS) 🥇2025 ACDS Professional Development Award 🥇 Applications are now open! Are you a PhD student or early-career researcher in the cell death field? Don’t miss your chance to apply for our $2,000 travel ...

(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!

A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.

More info below

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW

Quote of the day: “If you think research is expensive, try disease.” Mary Lasker

This is how your email finds me #catsOfAcademia #AustralianMist

(1/3) 🌍 We're kicking off our 2025 International Cell Death Seminar Series with @ecdo & @CDDpress on Wed 7 May!
🕓 4:30pm AEST / 8:30am CEST
📍 Online (Zoom link in poster)

A fantastic international line-up awaits... 🧵👇

Congrats @michelleyeaphw.bsky.social 🥳🙌

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...

So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...

New NIH ‘Indirect Costs’ Funding Cuts Threaten Universities, Science On Friday, the National Institutes of Health announced major cuts to funding of indirect costs for Universities, etc. Here's the potential impact on science and society.

Good story about indirect costs from Bruce Lee at Forbes.

www.forbes.com/sites/brucel...

Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death
www.cell.com/cell-reports...
@cp-cellreports.bsky.social @pablopelegrini.bsky.social

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems

CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems

Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...

Innate immune memory is stimulus specific
@arjunraj.bsky.social @aofarrell.bsky.social
doi.org/10.1101/2025...

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...

Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...

Mitochondria are suicide pills of the cell.

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.

Happy to share here: www.nature.com/articles/s41...

So excited to have our new paper out now!
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social

Ever wonder how cells in our epithelia fight for space? 🤔

Let's dive into the fascinating world of mechanical cell competition! #EpithelialMechanics

Hello, I am @akshar21.bsky.social and I'll be your guide through this thread on mechanical #CellCompetition

The last dance of a pyroptotic cell

Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation Mitochondria control metabolism, cell death, and innate immunity, yet their reciprocal mechanistic connections are elusive, as is the conserved physiological function of the NLRP3 inflammasome. Saller...

Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation
www.cell.com/immunity/ful...