Nao Okabe

Thank you! Happy to hear that!

(6/6)
A huge thank you to my co-authors, especially my PI, Tom Carmichael, for his incredible support.
Proud to represent
@UCLANeurology
in this work! Thanks to all the lab members, friends, and family who made this possible.

(5/6)
This study reveals the complex and heterogeneous circuit changes underlying stroke recovery. It also highlights the therapeutic potential of interneuron circuits as a target for recovery interventions.

(4/6)
Rehabilitative training recovers PV synapses, functional connectivity, and gamma power.

Using chemogenetics, we found that activating PV interneurons is essential for recovery. Remarkably, pharmacological PV activation mimics rehab benefits.

(3/6)
We identified neurons projecting to the stroke site (Stroke-projecting neurons) lose key synaptic inputs, including those from PV interneurons.

This loss disrupts functional connectivity, leading to decreased gamma power and impaired motor function.

(2/6)
Stroke recovery depends on plasticity.
Rehabilitation harnesses experience-dependent plasticity, but how specific neuronal circuits drive recovery has remained unclear—until now.

We identified key inhibitory circuits shaping rehabilitation-induced recovery.

Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug - Nature Communications The biological mechanisms of rehabilitation after stroke are not fully understood. Here authors identify parvalbumin interneurons as a key mediator of rehabilitation-induced stroke recovery and a drug...

Excited to share our new paper!

Our new paper in
@NatureComms
reveals how parvalbumin (PV) interneurons regulate stroke recovery by enhancing network synchronization.

Read here: nature.com/articles/s41...

#Neuroscience #StrokeRecovery #BrainPlasticity

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice - Nature A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...

🔥 Inflammation and neuron protection

In aging brains, genes associated with inflammation became more active, while those related to neuronal structure and function decreased.

Read the publication 📜 nature.com/articles/s41...