Our new preprint reveals that 🪰's Cnn and 🪱's SPD-5 both form condensates in vitro, but assemble via divergent mechanisms in vivo. We show how phosphorylation unlocks Cnn’s autoinhibited scaffold and identify conserved features in 🚶♂️'s CDK5RAP2.
05.10.2025 04:19 — 👍 8 🔁 4 💬 0 📌 0
The Company of Biologists 100 logo to the left and QR code to the right.
Portrait of Jordan Raff to the left, text to the right
100 extraordinary biologists
Jordan Raff
Former Company Director and Founding Editor-in-Chief of Biology Open, Jordan Raff is based at the University of Oxford. His lab works to understand the basic molecular mechanisms that regulate the assembly and function of centrioles and centrosomes.
#100biologists #biologists100
We are featuring Jordan Raff as our next extraordinary biologist. He is a former Company Director and Founding Editor-in-Chief of Biology Open. #100biologists
@jordanraff.bsky.social
14.01.2025 12:35 — 👍 24 🔁 7 💬 1 📌 0
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳
A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!
Check the full list here: www.path.ox.ac.uk/news-article...
17.04.2025 21:13 — 👍 17 🔁 2 💬 0 📌 2
The conserved Spd-2/CEP192 domain adopts a unique protein fold to promote centrosome scaffold assembly
A conserved structural domain within CEP192/Spd-2 protein promotes centrosome scaffold assembly during centrosome maturation.
🔬 Exciting findings from our collaborative study with Lea, Raff, van Breugel&Feng Lab! We've uncovered how Spd-2/CEP192 proteins with an SP2D structure are crucial for centrosome assembly. Crystal structures&mutations reveal new insights into PCM scaffold formation.
www.science.org/doi/10.1126/...
30.03.2025 04:28 — 👍 15 🔁 7 💬 0 📌 0
#biologists100
Please come to my poster on Wed at the Liverpool conference and see how the @jrafflab.bsky.social with @dunngogreen.bsky.social @dunnschool.bsky.social is conducting our world class science in an environment friendly way at @ox.ac.uk ! Saving money & planet! There is no planet B!
24.03.2025 16:30 — 👍 19 🔁 7 💬 0 📌 0
Happy to be here. Hopefully this will be fun and useful. Like Twitter used to be.
19.11.2024 08:33 — 👍 9 🔁 0 💬 1 📌 1
Curating and cataloging the world's data for the fruit fly Drosophila melanogaster into our database at http://flybase.org. Aiding discovery since 1992.
Drosophila geneticist, mol-cell biol., professor, raconteur.
I love mutants.
Postdoc @SophieMartinLab.bsky.social studying #GPCR and #MAPK signalling in fission yeast. Alumnus of @mjafreeman.bsky.social and @jordanraff.bsky.social
A supportive network for the cilia research community to share research and expertise. Account managed by Dr. Girish Ram Mali and ECR Advisory Group
https://www.cilianetwork.org.uk/
Group at MRC HGU using genetics, cell biology and lots of imaging to unlock the mysteries of mammalian #cilia. #cilia. #centrioles #cytoskeleton #RareDisease www.cilialab.co.uk
A friendly bot posting centrosome and centriole papers. Automated alter ego of @stearnslab.bsky.social
Scientist at St Jude using structural biology to try and understand how things work - views are my own not my institutions
Professor for Mucosal Immunology, ETH Zürich, Switzerland, and Sir William Dunn School of Pathology, Oxford, UK. We work on novel oral vaccines, AMR, and microbiome function. Making science fairer, kinder and more equitable 🏳️🌈🏳️⚧️. Views are my own.
Museum exec, MRC, visiting prof at the Dunn School, Oxford, and UCL Chemistry. Ex Editor of New Scientist, and Science Editor of the Telegraph. Co-author #VirtualYou and more books. Neutron bouncer
Professor of Molecular Immunology at the University of Oxford.
Experiments & Math(s) to understand and exploit T cells.
Founder & Director of MatchBio Ltd
Cell biologist, all things centrioles and centrosomes, Arsenal, Taylor
Molecular virologist and gardener.
Group leader & MRC CDA fellow at the Dunn School, Oxford. Cilia, motor proteins & intracellular organisation using cryo-EM/ET & cell biology. Run a co-lab with Anthony Roberts.
Statistical and Experimental Geneticist @ Oxford University | Henry Dale, Wellcome-Beit & Royal Society Fellow | Group Leader, Dunn School of Pathology, Oxford
germlinegenomics.web.ox.ac.uk
2024 BBSRC Fellow | University of Oxford | Junior Research Fellow at Linacre College | Investigating antibiotic resistance & tolerance, and better ways to kill pathogens 🧫
https://scholar.google.com/citations?hl=en&user=L2mEVzEAAAAJ
Group Leader/MRC CDA Fellow (Dunn School of Pathology, University of Oxford)
https://www.path.ox.ac.uk/research-group/girish-ram-mali/
Molecular Parasitologist. Teacher. Fascinated by how parasites interact with our immune system. Rational vaccine designer. Country boy and nature lover. 🏳️🌈
Science Strategy at the Dunn School, Public Engagement at Reuben College, both @Oxford Uni. Exec member of the UK Young Academy. Opinions here are my own.
Marie Curie Postdoctoral fellow at Oxford with Emma Slack | Fulford JRF at Somerville College | Infection ecology, immune-pathogen interactions, and science outreach | she/her 🇨🇦
Sir Henry Wellcome Fellow | Oxford with Ivan Ahel & Harvard with Steve Gygi
Molecular mechanisms of cysteine modifications | GlcNAc and ADP-ribose
Previously: The Francis Crick Institute/Imperial College London (postdoc), University of Dundee (PhD)
