Lars Jansen Lab

new CENP-A domains are seeded in heterochromatin mutants

SETDB1, previously implicated in transposon silencing, is a novel player in maintaining heterochromatin boundaries within core alpha satellites. This regulation is critical, as loss of heterochromatin integrity results in ectopic CENP-A domains and distal centromere nucleation!

We found that heterochromatin plays a key role in restricting the position of the CENP-A domain, ensuring only one CENP-A domain is nucleated per centromere. SUV39H1/2 and SETDB1 H3K9me3 methyltransferases differentially control neocentromeres, pericentromeric, and core alpha satellites.

We discovered that centromeric chromatin domains, composed of CENP-A variant nucleosomes, are highly plastic in their positioning at both neocentromeres and canonical alpha satellites.

differential contribution of H3K9 methyltransferases to boundaries at satellites

A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...

The discovery of CENP-A, the centromere-specific histone H3 variant turns 40 years!
Grant Rowley wrote a wonderful historical piece on the cell cycle control of this fascinating piece of chromatin! Check it out.
link.springer.com/article/10.1...

Great Team! Check out the Gruszka lab position and apply!

🚨 The Gruszka Lab is hiring!

We’re looking for a Researcher in Microscopy Image Analysis to join our team.

🔗 Know someone who might be interested? Share this post or tag them!

👉 Find out more and apply here: www.jobs.ac.uk/job/DNU476/r...
@mplsoxford.bsky.social @oxfordphysics.bsky.social

So sorry to miss this excellent meeting! Kudos to the organisers. Enjoy!

Many congrats to a great team effort at @oxfordbiochemistry.bsky.social

Fresh of the press! rdcu.be/egmY0 We discovered key chromatin modifications that are heritably maintained through mitotic cell divisions in the absence of continued transcription. These hold a memory of past exposure to interferon-gamma, priming cells for future activation of gene expression.

@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...

How to Apply and Funding

Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.

https://www.jansenlab.org/home

Join our team www.jansenlab.org as a @wellcometrust.bsky.social -funded postdoctoral fellow and help us discover how chromatin at human centromeres is formed and inherited. Position now open at @oxfordbiochemistry.bsky.social! See: my.corehr.com/pls/uoxrecru... for details!