Sebastian Gilbert

Lactate was known as a metabolic waste product from glycolysis, but more and more evidence shows it acts as a signaling molecule. Happy to have contributed with former great student @seb-math-bio.bsky.social‬ to the data analysis of a study in
/@natmetabolism.nature.com
showing how 1/

My friend Dr Rosie Evans has written a fantastic booklet, "What can you do?", with the Piscopia, academics, PiFORUM25 and me ☺️ For individuals and departments who want to take steps toward change.

sites.google.com/view/how-to-...

#maths #genderdiversity #EDI #WomenInSTEM #Ally #AllyshipInAction

Associate Editor @seb-math-bio.bsky.social is representing @mmls-journal.bsky.social at the @visiopharm.bsky.social 2nd UK User Group Meeting at the @unibirmingham.bsky.social, UK. This conference for unites unites digital pathology experts for talks, presentations, and networking.

🚨 New Publication Alert 🚨
How does social network structure shape the trade-off between infections and interactions? A new study by Bunlang Thatchai, Christopher E. Overton & @tah-sci.com explores this using a mathematical model of epidemic dynamics. 🧵

Do you work at the interface of disease dynamics and behaviour?

Consider submitting an article to a Special Issue in Behavioural Epidemiology at @mmls-journal.bsky.social.

Indicative paper submission is due 31st March 2025.

More details here: think.taylorandfrancis.com/special_issu...

🚨 New Publication Alert 🚨
How can the mathematics of fractals improve medical treatments? A new study in Mathematics in Medicine and Life Sciences explores just that! 🧵

Sebastian Gilbert BEAR Champion profile for Sebastian Gilbert.

Excited to become a BEAR Champion! 🐻 Supporting Birmingham Environment for Academic Research (@uob-bear.bsky.social) to empower researchers with cutting-edge HPC, data storage, and training at @unibirmingham.bsky.social. Check out my profile: birmingham.ac.uk/research/arc... #ResearchComputing

Side view of speaker standing in front of presentation slide with a colourful multiplex immunofluorescence image.

Honored to present at IIDSAI/@uob_bear Digital Research Conversations on "#AI-enabled Analysis of H&E Images from Sjögren Disease Patients" Exciting talk turned panel on building successful #Interdisciplinary collaborations! 👩‍💼🧑‍💻🧑‍🔬🧑‍🏭👩‍⚕️

Frontiers | Functional analysis of fibroblasts and macrophages in head and neck paragangliomas Background and aimHead and neck paragangliomas (HNPGN) are tumours that carry significant morbidity The role of the stroma in the pathogenesis of HNPGN is no...

For more details, check out the full study here: doi.org/10.3389/fend...
#CancerResearch #StromalBiology (8/8)

Our findings suggest that fibroblasts and macrophages play significant roles in the HNPGN tumor microenvironment. This adds to our understanding of the composition and activity of these tumors. (7/8)

In situ confocal microscopy showed that MCT1 & MCT4 were expressed in both HNPGN tumor cells and stromal macrophages. This points to potential metabolic interactions in the #TumorMicroenvironment. (6/8)

Fibroblasts derived from HNPGN expressed PDPN, as seen in healthy tissue fibroblasts, and markers like FAP, MCT1, CD220, & CD222 (via #FlowCytometry). These markers reflect their functional properties. (5/8)

RT-qPCR analysis confirmed the expression of macrophage- and fibroblast-associated molecules in HNPGN samples. These findings highlight the active role of stromal cells in these tumors. (4/8)

Using #Immunohistochemistry, we identified:
> CD68+ & CD163+ macrophages
> CD90+ & PDPN+ fibroblasts
These stromal cells were present in HNPGN tissues and may contribute to tumour behaviour. (3/8)

First, a shout out to the wonderful collaborators! Paramita Baruah, Jennifer L. Marshall, Meriam Nefla, Valentina Pucino, Holly Adams, Jason D. Turner, Emily Powell, Georgiana Neag, Peter Monksfield, Richard M. Irving, Adam P. Croft, Ingrid E. Dumitriu and Christopher D. Buckley (2/8)

📢Excited to share our new study on head and neck paragangliomas (HNPGN)! We focused on the role of #Fibroblasts and #Macrophages in the tumor microenvironment. Here's a breakdown of what we found🧵(1/8)

Hello world! I am an enthusiastic science communicator who loves applying maths to biomedicine ➗💊 I currently work as an Advanced Image Analysts Specialist at Birmingham Tissue Analytics in the University of Birmingham, UK. I look forward to sharing my thoughts and work with this new community 😀