Camiel Mannens

The new frontier in understanding human and mammalian brain development - Nature Recent studies integrating multi-omics data with cell atlases across development for brains of humans and model organisms are revealing conserved and divergent patterns of brain development at the mol...

Out now in Nature as part of the 'Brain Development' special issue, our perspective on the developing human and mammalian brain. www.nature.com/articles/s41...

06.11.2025 19:27 — 👍 8    🔁 1    💬 0    📌 0

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

25.06.2025 10:08 — 👍 115    🔁 109    💬 2    📌 3

You'd think they have stock in SAS

19.08.2025 13:26 — 👍 2    🔁 0    💬 0    📌 0

Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.

19.06.2025 05:50 — 👍 24    🔁 17    💬 0    📌 1

Dozens of active and planned NASA spacecraft killed in Trump budget request Proposal would end nearly all new major science missions

Breaking from @science.org: The Trump administration wants to kill off a host of active and healthy NASA climate and planetary spacecraft. It would be a "leaner, more focused" agency, they say -- and one far less capable of studying the Earth and exploring space.

30.05.2025 22:58 — 👍 367    🔁 219    💬 11    📌 17

Congratulations Karl!

28.05.2025 18:46 — 👍 1    🔁 0    💬 0    📌 0

Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex Johansen et al. report the results of a community challenge to predict functional enhancers targeting specific brain cell types. By comparing multi-omics machine learning approaches using in vivo data...

Check out our work on evaluating methods for predicting in vivo cell enhancer activity in the mouse cortex! Combined, scATAC peak specificity and sequence-based CREsted predictions gave the best predictive performance, aiming to advance genetic tool design for cell targeting in the brain.

21.05.2025 16:45 — 👍 20    🔁 10    💬 1    📌 0

Data collected with the new sequencing platform HyDrop v2 is shown. First, a schematic overview of the bead batches of the microfluidic beads is followed by a tSNE and a barplot showing the costs in comparison to 10x Genomics. Then, a track of mouse data (cortex) is shown together with nucleotide contribution scores in the FIRE enhancer in microglia. Here, the HyDrop and 10x based models show the same contributions. On the right, the Drosophila embryo collection is explained; in the paper HyDrop v2 and 10x data are compared to sciATAC data. Then, a nucleotide contribution score is also shown, whereas HyDrop v2 and 10x models show the same contribution, just as in mouse.

Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2!
www.biorxiv.org/content/10.1...

04.04.2025 08:52 — 👍 55    🔁 25    💬 2    📌 2

CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species Sequence-based deep learning models have become the state of the art for the analysis of the genomic regulatory code. Particularly for transcriptional enhancers, deep learning models excel at decipher...

Very proud of two new preprints from the lab:
1) CREsted: to train sequence-to-function deep learning models on scATAC-seq atlases, and use them to decipher enhancer logic and design synthetic enhancers. This has been a wonderful lab-wide collaborative effort. www.biorxiv.org/content/10.1...

04.04.2025 09:04 — 👍 109    🔁 39    💬 5    📌 1

NEWS This Brazilian frog might be the first pollinating amphibian known to science

It’s the first time a frog—or any amphibian—has been observed pollinating a plant, researchers reported in 2023.

Learn more on #WorldFrogDay: scim.ag/4kGdvCy

20.03.2025 19:34 — 👍 610    🔁 159    💬 10    📌 25

Congrats Camiel, awesome to have you in the lab!

26.02.2025 12:17 — 👍 7    🔁 1    💬 1    📌 0