@gioelelamanno.bsky.social
Professor at #EPFL - #RNAVelocity inventor - Laboratory of Brain Development and Biological Data Science. Single-cell and spatial biologist studying brain development and lipids. #ERCStg investigator
5um dot size, 20um step.
Max resolution is 4um as far as I know
It was such an exciting experience to learn about the cutting edge science at the VIB! Thank you for having me!
16.10.2025 22:37 — 👍 1 🔁 0 💬 0 📌 0Wow @gioelelamanno.bsky.social & @giodang.bsky.social
16.10.2025 07:09 — 👍 11 🔁 2 💬 0 📌 0This is a massive undertaking by a courageous group of experimentalists and computational scientists. I am honored to have contributed to this. #lipidtime chenges time zone today
16.10.2025 07:35 — 👍 22 🔁 5 💬 1 📌 0We're very much looking forward to your talk!
16.10.2025 07:35 — 👍 2 🔁 1 💬 0 📌 0Fantastic Gioele!
16.10.2025 07:47 — 👍 1 🔁 2 💬 0 📌 0Wow!
16.10.2025 09:29 — 👍 3 🔁 1 💬 0 📌 0This is truly great work -and will be a fantastic resource for the community!
16.10.2025 09:41 — 👍 11 🔁 1 💬 0 📌 0🎉🎉🎉🎉🎉
16.10.2025 11:01 — 👍 3 🔁 2 💬 0 📌 0Amazing work Gioele et al. Your talk about the lipid brain atlas and how it connects within a grand vision, this morning at VIB.ai, was truly spectacular. We were honoured to hear the story on the day of the preprint :)
16.10.2025 11:18 — 👍 3 🔁 1 💬 0 📌 0Happy to finally see The Lipid Brain Atlas out! Lipids are not boring at all so, check it out!
Amazing team effort between computational and experimental work, led by @lucafusarbassini.bsky.social with @gioelelamanno.bsky.social and @giodang.bsky.social labs. Proud to be part of it.
Lipids rule!
Fantastic story! Congratulations to everyone involved!
16.10.2025 15:49 — 👍 3 🔁 1 💬 0 📌 0
Such a treat to host @gioelelamanno.bsky.social (EPFL) today and be the first to hear more about his lab's latest work, posted just two days ago on bioRxiv.
Missed the talk?
Here's the preprint: https://www.biorxiv.org/content/10.1101/2025.10.13.682018v1
With this reference atlas, we can embark on new missions to track how disease, aging, diet, and drugs reshape the brain lipidome at the resolution where change happens.
16.10.2025 06:23 — 👍 4 🔁 1 💬 0 📌 0Through the lipidome, we bring into sharp focus cell-type-specific metabolism and membrane biochemistry, and also glimpse developmental history and connectivity patterns.
16.10.2025 06:23 — 👍 2 🔁 0 💬 1 📌 0- Biochemical zonation of the choroid plexus and ventricular linings.
- Pregnancy triggers coordinated membrane adaptations from cortex to white matter.
- Sex differences in white matter sphingolipids are amplified during pregnancy.
- The lipidome alone can predict 3D coordinates of brain tissue.
- Oligodendrocytes are lipidomically heterogeneous in the corpus callosum.
- In the gray matter, many lipizones capture cell-type territories.
- Lipid signatures connect cell bodies to distant axon terminals across the brain.
@epfl-brainmind.bsky.social @neuroxepfl.bsky.social
!!!We found that lipids act as zip codes for fine-grained brain anatomy!!!
✨ Specifically, we discovered:
- #LIPIZONES: brain territories defined purely by lipid composition, no anatomical priors needed.
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
I am boarding a plane headed to @vibai.bsky.social. Super excited to present the culmination of one of the most exciting projects of recent years, as well as introducing my new vision of an #AI-powered #Brain #Atlas
15.10.2025 16:06 — 👍 8 🔁 0 💬 0 📌 1I dedicate the achievement to my family, whose patience and support through every creative burst made this possible.
04.09.2025 14:38 — 👍 3 🔁 0 💬 0 📌 0
I am deeply honoured to have been recognized by the European Research Council with a #StartingGrant. @erc.europa.eu
With this support, my team and I will launch #MOVIOLA. Our goal is to understand how human neural progenitors decide their fate during brain development.
uMAIA offers an analytical framework designed to enable construction of high-resolution metabolic atlases using mass spec imaging data. @gioelelamanno.bsky.social
www.nature.com/articles/s41...
Proud of these advances, achieved in great company @EPFL : @giodang.bsky.social (co-PI), with Halima Schede & Leila Alieh leading the project, and the Oates lab bringing their zebrafish expertise [2/2]
03.09.2025 16:16 — 👍 1 🔁 1 💬 0 📌 0
Excited to share #uMAIA, our method to create 4D lipidomic atlases, now published in @natmethods.nature.com
We demonstrate that with uMAIA, the field is ready for atlas-level analyses capable of uncovering histological metabolic heterogeneity in both space and time. [1/2]
Proud of these advances, achieved in great company @EPFL : @giodang.bsky.social(co-PI), with Halima Schede & Leila Alieh leading the project, and the Oates lab bringing their zebrafish expertise [2/2]
03.09.2025 16:14 — 👍 0 🔁 0 💬 0 📌 0In my view even “function” isn’t well-posed concept. Context, timing, cell type, and interactions matter. Genes products have conditional context-dependent effects which have retrospecrivelly contributed to fitness.
03.09.2025 05:29 — 👍 1 🔁 0 💬 0 📌 0
And he made it again!...tour the force from JIa-Wei´s Wang lab using comparative sc-transcriptomes, and developing new analytical tools, to tackle evolutionary trajectories of plant cell types!. Amazing work as usual! www.cell.com/cell/abstrac...
20.08.2025 15:50 — 👍 20 🔁 8 💬 0 📌 0A little over two weeks to the deadline! 20 positions, generous startup funding, a great community and fantastic infrastructure. Come join us!
15.08.2025 21:23 — 👍 8 🔁 12 💬 0 📌 0Join us at the FENS Single-Cell & Spatial Omics Winter School with:
@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
