Pierre Vanderhaeghen

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development Yim et al. use single-cell transcriptomics to elucidate the molecular outcomes of Chd8 haploinsufficiency in the mouse cortex. Their results provide insight into dynamic, cell-type-biased transcriptio...

Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵:
www.cell.com/cell-genomic...

Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics Developmental processes display temporal differences across species, leading to divergence in organ size and composition. In the cerebral cortex, neurons of diverse identities are generated sequential...

New from the lab: Fatty Acid Metabolism Sets the Species-specific Tempo of Cortical Development through Protein Acetylation Dynamics. Led by amazing trio: @ryo2iwata.bsky.social , Isabel Gallego, @emirerkol.bsky.social, together with @steinaerts.bsky.social , @fendtlab.bsky.social

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Beautiful and inspiring work from Gero Miesenböck and colleagues www.nature.com/articles/s41...

May has been quite the month…

The #EvoDevoConference was a blast 💥

Thanks to all participants and organizers for your engagement!

@mdiazcuadros.bsky.social @bassemh.bsky.social @vanderhaeghenp2.bsky.social

📸
(1/2)

Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...

Hot off the press:
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010

wonderful - congratulations @debbysilver.bsky.social !!

Fantastic opportunity for neuroscience research.
The ROGER DE SPOELBERCH Prize for a basic or clinical research project in the areas of neurodegenerative diseases or psychiatric disorders.
750.000 EUR - Deadline JUNE 30 2025.
www.fondation-roger-de-spoelberch.ch/en/roger-de-...

VIB.AI International PhD Call 2025 The VIB.AI International PhD Call 2025 is now open. We invite applicants from around the world to join an interdisciplinary research environment at the interface of AI, computational biology, and life...

Fantastic PhD opportunities at the intersection of machine learning and biology. Come join us at @vibai.bsky.social! More details at: vib.ai/en/vibai-int...

Join us in Engelberg, Switzerland, for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys!
Great speaker line up and opportunities for short talks from early career scientists.
Submit your abstract until May 30st!
@jcourchet.bsky.social @tatjanakleele.bsky.social

I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬

📅 registration closes MAY 30th, so don’t wait to snag your spot!

Stay tuned - more updates about the topics and speakers coming soon! 🎙️

It’s out! The first paper from my postdoc – and first from the @bhadurilab.bsky.social – is now live @natneuro.nature.com . 🧠✨

Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)

Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color A GWAS including 192,986 European and 1636 Asian participants identifies 50 novel discrete associations with eye color.

Turns out eye colour (mainly a result of iris pigmentation) is yet another complex trait, now demystified by genomic advances. DNA variants in two neighbouring genes (HERC2 & OCA2) explain much of the blue-brown variation, but analyses of ~193k people in 2021 revealed another 50 genetic loci. 👇 7/n

Very cool study from Ikuo Suzuki lab, comparing temporal patterning in mouse and rat cerebral cortex.

Non-uniform temporal scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes.

www.biorxiv.org/content/bior...

Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels. Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the rod-dominant retinas of most mammals. The molecular mechani...

Our latest manuscript (7 years in the works) tackles the question of how diurnal ground squirrels evolved a cone-dominant retina, in contrast to the ancestral rod-dominant retina retained by virtually all other mammals./1
www.biorxiv.org/content/10.1...

Postdoc position: Computational methods for neurodegeneration research - VIB About the labs The Verstreken Lab and the Gonçalves Lab are based in Leuven, Belgium and part of the

Exciting project in Parkinson's disease! Patrik Verstreken's lab (verstrekenlab.sites.vib.be) and my lab are looking for a postdoc to develop and apply ML methods to the analysis of exciting brain-on-chip data. Please spread the word!

More details at: jobs.vib.be/j/110908/pos...

Very excited to share our new preprint together with @daniedaaboul.bsky.social, where we studied the gene regulatory code that hippocampal granule cells (GCs) use during synapse formation (1/n)

With beautiful illustration of calcium imaging of human cortical neurons in visual cortex of awake transplanted mice by @benvermaercke.bsky.social @boninlab.bsky.social

In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain Transplanted cells offer insight into human-specific properties, such as a lengthy cortical development and sensitivity to neurodevelopmental and neurodegenerative disease.

A short Perspective on xenotransplantation to study human neuron development, evolution and disease
@thetransmitter.bsky.social
More related articles on human neurobiology coming out soon - thanks a lot to Josh Sanes for the initiative and opportunity!
www.thetransmitter.org/human-neurot...

The latest essay in our new essay series exploring technologies for studying the human brain, guest edited by Josh Sanes.

Developmental timing across species: From mechanisms to evolutionary insights Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…

EMBOMtg Paris May 6-9
@aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social
meetings.embo.org/event/25-dev...

Developmental timing across species: From mechanisms to evolutionary insights Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…

Join us in Paris in May 6-9 for an exciting EMBO Workshop on Developmental timing mechanisms and evolution. Slots still open for short talks - Registration deadline next week!@bassemh.bsky.social @trayon.bsky.social @mdiazcuadros.bsky.social

meetings.embo.org/event/25-dev...

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz
Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

Developmental timing across species: From mechanisms to evolutionary insights Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…

Join us for this exciting EMBO workshop in Paris May 6-9 on a fundamental emerging question in biology: Mechanisms that control species-specific development timing (Deadline for registration fast approaching April 1).
meetings.embo.org/event/25-dev...

From Bluesky folk: @cedricboeckx.bsky.social @debbysilver.bsky.social @blibep.bsky.social @franckp.bsky.social @vanderhaeghenp2.bsky.social @joanocha.bsky.social @psudmant.bsky.social @evobioclio.bsky.social @mydennis.bsky.social @alwaysrong.bsky.social @baumoflife.bsky.social @noonanlab.bsky.social

Developmental timing across species | EMBO Workshop | 6-9 May - the Node Join us at the EMBO Workshop "EvoDevoTempo – Developmental Timing Across Species: From Mechanisms to Evolutionary Insights". Topics will include

"Developmental Timing Across Species"

@embo.org Workshop organised by @trayon.bsky.social @bassemh.bsky.social @mdiazcuadros.bsky.social @vanderhaeghenp2.bsky.social

📅6-9 May 2025
📍Paris

Submit abstract and register by 1 April:
thenode.biologists.com/developmenta...

#EvoDevoTempo

Mitochondrial control of ciliary gene expression and structure in striatal neurons Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sens...

New lab paper! We reveal a novel mitochondria–cilia interaction in neurons & #mitochondrial control of #ciliary molecular pathways & structure

Kudos to Dogukan Ulgen & Ale Chioino
🙏 O Zanoletti, A Quintana, E Sanz
@epfl-brainmind.bsky.social @jphysiol.bsky.social
Read doi.org/10.1113/JP28...

Join us this coming May 6-9 in Paris for the second EMBO Meeting on developmental timing across species.
Registration now OPEN. Stellar line-up of inv. speakers + talks selected from abstracts.
meetings.embo.org/event/25-dev...

@trayon.bsky.social @bassemh.bsky.social @mdiazcuadros.bsky.social

#EvoDevoTempo

Final poster for the second edition of the #EvoDevoTempo meeting is finally ready!

Great lineup and 3x more social activities:
meetings.embo.org/event/25-dev...

@bassemh.bsky.social @mdiazcuadros.bsky.social @vanderhaeghenp2.bsky.social