Fabrizio Chiodo

154 million lives and counting: 5 charts reveal the power of vaccines But public-health specialists worry that misinformation and funding cuts could affect vaccination rates.

154 million lives and counting: 5 charts reveal the power of vaccines. Story by @heidiledford.bsky.social www.nature.com/articles/d41...

Safeguarding immunisation: a core function of WHO Vaccination remains the most cost-effective public health intervention, preventing millions of deaths and reducing disease burden worldwide.1 However, their impact is rendered meaningless if vaccines ...

Safeguarding immunisation: a core function of WHO - The Lancet www.thelancet.com/journals/lan...

Microplastics are facilitating antibiotic resistance
journals.asm.org/doi/epub/10.... open-access

Asteroid fragments upend theory of how life on Earth bloomed Samples from Bennu contain the chemical building blocks of life - but with a twist.

Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise

https://go.nature.com/4hDtGhL

Brain microbiome: is it all in our heads? In their September 2018 Editorial, The Lancet Infectious Diseases discussed the over-reaching inferences leading to suggestions of a placental microbiome, and touched on how the same extrapolations we...

Our latest editorial is now online, in advance of our February issue that will be available next week.

Brain microbiome: is it all in our heads?

www.thelancet.com/journals/lan...

#CLRpower! Sensing of microbiota after gut barrier disruption reprograms the bone marrow & myeloid functions via the C-type lectin receptor Mincle!! @cp-immunitt.bsky.social from @sancholab.bsky.social &co! 👇👇👇

But, who is sensing E. faecalis? We found that Mincle is sensing E. faecalis and that Mincle mediates trained immunity in response to their many ligands. Staphylococcus aureus, another bacteria translocated to the BM, is also sensed and inducing trained immunity via Mincle.

Jason Lyon illustration

New paper alert 📢! (Cell) @cp-cell.bsky.social
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8

Polysialylation is a general feature of immune activation Sialic acids are critical regulators of immune responses and the sialic acid-Siglec axis has receive much attention recently for it role as a new immune checkpoint. While α2,3- and α2,6-linked sialosi...

Polysialic acids are upregulated on activated T cells #glycotime

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...

#InterferonPower! Khan Tran Divanghai &co show @natimmunol.bsky.social that systemic fungal b-glucan administration potentates granulopoieis via type I IFNs (not IL1!) driving IL10-producing neutrophils that protect against lung influenza A virus infection increasing immune tolerance, not resistance

5 years ago, on 31st December 2019, COVID-19 came to shape our lives and our world.

Five years ago, on 31 December 2019, WHO’s Country Office in #China picked up a media statement by the Wuhan Municipal Health Commission from their website on cases of ‘viral pneumonia’ in Wuhan, China. 🧵

Immunization is a game-changer! It ensures babies not only celebrate their first birthdays but also thrive into healthy adulthood.

In 2024: - 17 countries introduced the malaria vaccine - The WHO HPV vaccine single-dose schedule enabled more girls to be protected against cervical cancer - A new meningitis vaccine offered a powerful shield against the five major strains of the meningococcal bacteria in a single shot

Global immunization efforts have saved an estimated 154 million lives – that is 6 lives every minute – since the founding of the Expanded Programme on Immunization, 50 years ago.
bit.ly/4gpxQJK

Carbohydrate-mediated interactions between chloroviruses and the immune system - Communications Biology This study explores how viral N-linked glycans play a role in the interaction between chloroviruses glycoproteins and key receptors of the innate immune system.

"Collectively, these results demonstrate the ability of the innate and adaptive immune systems to recognize chlorovirus glycoproteins, a process dependent on their specific N-glycan structures..."

Our #glycotime study just published @commsbio.bsky.social

www.nature.com/articles/s42...

Glycoconjugate vaccines: platforms and adjuvants for directed immunity Abstract. Central to immune recognition is the glycocalyx, a glycan-rich coat on all cells that plays a crucial role in interactions that enable pathogen d

Valerie Lensch of @kiesslinglab.bsky.social and the Johnson group reviewed different glycan-based strategies for eliciting an immune response: academic.oup.com/glycob/artic... #glycotime

A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...

New 🚨 #glycotime in @science.org H5N1 "a Gln226Leu substitution switched Texas HA binding specificity to human-type receptors, which was enhanced when combined with an Asn224Lys mutation"

⬇️⬇️

www.science.org/doi/10.1126/...

The danger theory of immunity strikes back... rdcu.be/d1uQN

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.

This month in #ScienceImmunology, @virusesimmunity.bsky.social & colleagues reported that #ERV -reactive #B1Cells secrete #antibodies that recognize GlcNAc moieties on both ERV #glycoproteins as well as glycoproteins of other enveloped #viruses!

This malaria vaccine is delivered by a mosquito bite Bites from insects infected with modified malaria parasites boosted immunity and stopped people from contracting the disease.

www.nature.com/articles/d41...