Mychael Lourenco

Emerging autism and Fragile X syndrome treatments The limitations of current symptom-focused treatments drive the urgent need for effective therapies for autism and Fragile X syndrome (FXS). Currently…

Check out our latest review @cp-trendspharma.bsky.social, outlining emerging pharmacological interventions for #autism and #fragileXsyndrome. A nice collaboration with Amedeo D'Agiulli, Vivian Lee and @salmasolab.bsky.social! #neuroskyence:
www.sciencedirect.com/science/arti...

Social disadvantage accelerates aging - Nature Medicine Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.

www.nature.com/articles/s41...

Women twice as likely to develop Alzheimer’s disease as men — but scientists do not know why - Nature Medicine Changes to the female brain during menopause, together with social and cultural factors, might affect disease risk.

Women twice as likely to develop Alzheimer’s disease as men — but scientists do not know why

www.nature.com/articles/s41...

Happy to be in Taipei for the @embo.org Workshop - Neural development and neurodegeneration!

Aging activates escape of the silent X chromosome in the female mouse hippocampus Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

Aging activates escape of the silent X chromosome in the female mouse hippocampus
www.science.org/doi/10.1126/...

AAIC Satellite Symposium | Alzheimer’s Association Join leading research experts at the 2025 AAIC Satellite Symposium in Lima, Peru, and online to network & explore emerging dementia research.

Don’t miss the chance to present your work at the #AAICSatellite Symposium in Lima, Peru & strengthen the future of the dementia science community in Latin America. Abstracts  are due Feb. 24: alz.org/satellite-symposium

Join us one week from today for the second virtual roundtable in our Dementia in Latin America and the Caribbean series. Leading dementia experts will dive deep into brain health and social determinants of health. Learn more: bit.ly/40PzSwd

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment RNA-Seq analysis and molecular biological approaches reveal a novel mechanism and provide a promising preventive and therapeutic molecular target for vulnerability to chronic pain-related memory impai...

You can also read the original paper here:
elifesciences.org/articles/99862

Pain-Related Memory Impairment: How does chronic pain lead to memory loss? A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.

Our comment on a very interesting @elife.bsky.social
paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out!
elifesciences.org/articles/105...

Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia.
www.nature.com/articles/s41...

We had essential collaborations with D'Or Institute (Brazil) and @elizabethhead.bsky.social @ucirvine.bsky.social and very much appreciate the important funding by NIH, @serrapilheira.org and Alzheimer's Association.

Plasma carnitine also associate with Aβ and tau accumulation and further improved AD classification when combined with CSF Aβ and tau. Check it out if you're interested! #ENDALZ

Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts - Molecular Psychiatry Molecular Psychiatry - Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

Happy to share this study led by Betty Bigio, Carla Nasca (NYU) and our team @ufrjoficial.bsky.social just published in Molecular Psychiatry. Here, using two cohorts, we show that plasma carnitine levels are reduced in women with cognitive impairment and dementia.
www.nature.com/articles/s41...

Biological sex matters in brain aging Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …

Male-Female comparisons are powerful in Biomedical Research. More on this and what is a "Pink Box Warning"?? From @ctmurphy1.bsky.social @bbparis1984.bsky.social Yousin Suh and me in the latest issue of Neuron www.sciencedirect.com/science/arti...

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease

www.nature.com/articles/s41...

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice - Nature A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...

A recent study by Kelly Jin, Zizhen Yao, Cindy van Velthoven, et al. @alleninstitute.bsky.social "provides detailed single-cell transcriptomic map of brain aging & has uncovered cell-type-specific & region-specific molecular changes linked to aging."

@nature.com
www.nature.com/articles/s41...

Our spotlight on @cp-trendsneuro.bsky.social, commenting on this great article by the Herfert Group 👇

Happy 2025 to all my colleagues and friends here!

a cartoon cat looking at a christmas tree in a pink room ALT: a cartoon cat looking at a christmas tree in a pink room

Happy Christmas to all those who celebrate! I hope you all have a great season.

RNA encodes physical information Most amino acids are encoded by multiple codons, making the genetic code degenerate. Synonymous mutations affect protein translation and folding, but their impact on RNA itself is often neglected. We ...

www.biorxiv.org/content/10.1...

new preprint!

www.biorxiv.org/content/10.1...

a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)

first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over ma…

www.sciencedirect.com/science/arti...

Heroes of the Engram In 1904, Richard Semon introduced the term “engram” to describe the neural substrate responsible for (or at least important in) storing and recalling memories (i.e., a memory trace). The recent introd...

www.jneurosci.org/content/37/1...

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal enzymes are exocytosed. The PI3K-AKT pathway modulates this process. Microglia also exocytose intralysosomal undigested fibrillar Aβ toward extracellular aggregates, potentially contributing to plaque growth.

www.cell.com/cell-reports...

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

Too many authors to list here, but very happy to have contributed to this review‬⁩ led by Michael Heneka on #neuroinflammation in #Alzheimer‘s disease, now out in @natrevimmunol.bsky.social. @dzne.bsky.social

www.nature.com/articles/s41...

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation. https://www.biorxiv.org/content/10.1101/2024.12.05.626721v1

Understanding the molecular diversity of synapses - Nature Reviews Neuroscience The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...

www.nature.com/articles/s41...

Important findings from the investigational AL-002 trial. These results, though disappointing in terms of clinical outcomes, may substantially inform future approaches and help us better understand Alzheimer's pathophysiology.
investors.alector.com/news-release...

‘Dark proteome’ survey reveals thousands of new human genes Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

'But a new systematic analysis of what some call the “dark proteome” suggests scientists have missed thousands of nontraditional genes that lurk in previously overlooked stretches of the genome and make smaller than average proteins.'
www.science.org/content/arti...

How many cool observations have we missed because of fixation artifacts?! Cool descriptive work from Shigeki’s lab.