Brian Sweis

🧠📢 New preprint alert

Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵

#neuroskyence #compneurosky

(1/6) We have a new paper out in #eNeuro!

How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆

Read more: www.eneuro.org/content/12/1...

Characterizing neuronal population geometry with AI equation discovery The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...

1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...

🚨 Reminder: Applications for #OptoGRC2026 are now OPEN!

Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠

Apply now for the best chance of acceptance: www.grc.org/optogenetic-...

NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...

It’s giving Dr. T.J. Eckleburg

A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...

Stop by our posters tomorrow afternoon at #SFN25!! #sfn2025 @sfn.org #neuroscience

Large-scale cellular-resolution read/write of activity enables discovery of cell types defined by complex circuit properties The complexity of the mammalian brain’s vast population of interconnected neurons poses a formidable challenge to elucidate its underlying mechanisms of coordination and computation. A key step forwar...

✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
www.biorxiv.org/content/10.1... 1/13 🧵

…plus a ZZZEST for experiment 🤓

Our Behavioural Brain Research special issue on Ultrasonic Communication in Rodents is growing, rapidly – and actually a lot faster than I manage to post about it. Nine new manuscripts got accepted since my last post. Quite impressive work. Check it out:
www.sciencedirect.com/special-issu...

Postdoctoral Fellow-MSH-13400-363 in New York, NY | Mount Sinai Health Systems Mount Sinai is hiring a Postdoctoral Fellow-MSH-13400-363 in New York, NY. Review all of the job details and apply today!

📣We are hiring! 📣 
Join us as a Postdoctoral Researcher to study brain–body interactions uncovering how neural and physiological systems regulate behavior and energy metabolism under stress!

Details are below:
📩 abha.rajbhandari@mssm.edu
🔗 careers.mountsinai.org/jobs/3032214

@eandraka.bsky.social @alex-ramirez22.bsky.social @neuromanonyc.bsky.social @scottrussophd.bsky.social @denisejcai.bsky.social @jdbux.bsky.social Hailey Rosenblum, Nusrat Jahan, Daniela Schiller

For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social

"The way forward has become very clear"- Dr. Brendan G. Carr
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!

Apathy, effort-based decisions and brain integrity in Alzheimer’s and Parkinson’s diseases Morris et al. identify a common behavioural signature of apathy in Alzheimer’s and Parkinson’s disease: a decision bias towards rejecting the option to exe

When I moved to BCM, an extremely talented movement disorders neurologist, Nora Vanegas Arroyave, reached out to discuss brain circuits responsible for non-motor deficits in Parkinson's Disease. I have learned so much from her and from this collaboration. One paper out, more to come!

Apply SOCIAL INTERACTION &<br>NEURAL COMPUTATION LAB. The SINC Lab examines the neural and computational basis of social cognition and interaction. We are particularly interested in understanding how social...

We are also considering applications from undergraduate students and Master's students in the local New York City area!

Please check out our website for more information on how to become involved: sinclaboratory.com/apply

Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream
connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵

nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging

Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social

We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠

So excited for this! Can't wait to see everyone there!

The amygdala helps mobilize #Stress hormones cortisol & adrenaline w/in about 15 minutes. A recent study by Icahn Mount Sinai's Dr. Sarah Stanley suggests a 2nd role for the #Amygdala in response to #Fear & #Anxiety. Dr. Stanley discusses her research @pnas.org 👉 www.pnas.org/post/journal...

Sosa Lab

The Sosa Lab website is now live!
www.sosaneurolab.com

We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.

#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬

Couldn’t be more excited to see this work out!! Not just manipulating PV+ cell theta phase, but also shifting seizure susceptibility! how much cooler can it get?!!!

Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.

🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)

Neuro Current Ep. 38 features #JNeurosci authors discussing their paper on disrupted choice behaviors in a rat model of FASD. Listen to learn more about their methods.
🎧Listen: vist.ly/45w9g
📺 Watch on demand: vist.ly/45w99