Brian Sweis

@eandraka.bsky.social @alex-ramirez22.bsky.social @neuromanonyc.bsky.social @scottrussophd.bsky.social @denisejcai.bsky.social @jdbux.bsky.social Hailey Rosenblum, Nusrat Jahan, Daniela Schiller

For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social

"The way forward has become very clear"- Dr. Brendan G. Carr
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!

Apathy, effort-based decisions and brain integrity in Alzheimer’s and Parkinson’s diseases Morris et al. identify a common behavioural signature of apathy in Alzheimer’s and Parkinson’s disease: a decision bias towards rejecting the option to exe

When I moved to BCM, an extremely talented movement disorders neurologist, Nora Vanegas Arroyave, reached out to discuss brain circuits responsible for non-motor deficits in Parkinson's Disease. I have learned so much from her and from this collaboration. One paper out, more to come!

Apply SOCIAL INTERACTION &<br>NEURAL COMPUTATION LAB. The SINC Lab examines the neural and computational basis of social cognition and interaction. We are particularly interested in understanding how social...

We are also considering applications from undergraduate students and Master's students in the local New York City area!

Please check out our website for more information on how to become involved: sinclaboratory.com/apply

Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream
connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵

nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging

Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social

We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠

So excited for this! Can't wait to see everyone there!

The amygdala helps mobilize #Stress hormones cortisol & adrenaline w/in about 15 minutes. A recent study by Icahn Mount Sinai's Dr. Sarah Stanley suggests a 2nd role for the #Amygdala in response to #Fear & #Anxiety. Dr. Stanley discusses her research @pnas.org 👉 www.pnas.org/post/journal...

Sosa Lab

The Sosa Lab website is now live!
www.sosaneurolab.com

We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.

#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬

Couldn’t be more excited to see this work out!! Not just manipulating PV+ cell theta phase, but also shifting seizure susceptibility! how much cooler can it get?!!!

Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.

🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)

Neuro Current Ep. 38 features #JNeurosci authors discussing their paper on disrupted choice behaviors in a rat model of FASD. Listen to learn more about their methods.
🎧Listen: vist.ly/45w9g
📺 Watch on demand: vist.ly/45w99

Congrats Herbert and team!

Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.

Research Network 2023 Pilot & Feasibility awardee @brianmsweis.bsky.social published two papers in Science Advances in July of this year that feature his research on the neuroeconomics of decision making. Join us in congratulating Dr. Sweis!

shorturl.at/d65WV
shorturl.at/DoU4p

Welcome to one of our newest @acnporg.bsky.social Associate Members, Dr. Brian Sweis 🎉

#WelcomeToACNP👋

Congrats to Brian Sweis, M.D., Ph.D. a new Associate Member of ACNP! Welcome!! 👋

Abstract submission open for The Mechanistic Basis of Foraging 2025 (U. Birmingham, 3-5 November)

uobevents.eventsair.com/the-mechanis...
Deadline: August 17

A meeting for all fascinated by the brain's role in foraging

Pls share!

Congrats!

This speaks to the importance of cross-species research that is constantly forward- & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in psychiatry🧠 tinyurl.com/yur3j2n8

+ evidence that sensitivity to sunk costs & change-of-mind regret stem from a shared value function related to negative rumination & stress susceptibility. Congrats @neuromanonyc.bsky.social @ornaissler.bsky.social @ericjnestler.bsky.social @scottrussophd.bsky.social & team!🧠 @sinaibrain.bsky.social

Here, we discovered LINC00473 in mPFC specifically altered change-of-mind decisions in female mice only. This was driven by enhanced sensitivity to sunk costs and how much re-evaluating recent mistakes influenced future choices. This is the 1st demo of non-coding RNA playing a role in cognition 5/6

A recent study led by @ornaissler.bsky.social found levels of the non-coding RNA LINC00473 were reduced specifically in mPFC 🧠 of women but not men diagnosed with MDD, based on post-mortem human 🧠 tissue studies. Expressing LINC00473 in mPFC promotes resilience to stress in female mice only. 4/6 🐭

Women are 2x as likely to develop depression than men. Major depressive disorder can manifest w different symptoms b/t sexes, including alterations in negative rumination on the past. Combining clinical questions, behavioral neuroscience, & translational #neuroeconomics, we dove into this deeper 3/6

We found striking sex differences in only change-of-mind choices, and not initial value-based judgements, in mice 🐭 working for food rewards of varying costs (delays ⏰) & preferences (flavors 🧀🍌🍫🍇) on our #neuroeconomic foraging task, Restaurant Row, while on a limited daily time budget. 2/6

Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.

New paper alert!🚨📝

Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8

How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances