Fany M. Real

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

📢New paper in @natecoevo.nature.com!
🦇Research reveals that bat wings form by reusing existing genetic programs

By @molgen.mpg.de, @mdc-berlin.bsky.social,
@cabd-upo-csic.bsky.social (@dariloops.bsky.social‬, @fany-real.bsky.social) & CNAG (@mamartirenom.bsky.social‬)

www.cnag.eu/news/flying-...

Very cool, Anna! Science communication is also an important part of our job, thanks for doing it with such passion! Bats rock! 😁

The molecular remix of bat wing evolution How do you build a wing from a hand? In bats, it’s all about remixing the molecular beat. The core gene circuitry is shared with other mammals, the innovation lies in timing and context.

🦇🦇🦇

darkgenomevo.wordpress.com/2025/07/29/t...

Special thanks to @kingsleyevan.bsky.social for the kind comment on the Expert Opinion, really appreciated!

Evolving a bat wing by reusing an existing gene program Nature Ecology & Evolution - Interspecies comparative analyses of single-cell transcriptomic data reveal that a proximal limb gene program is reactivated during bat wing formation. Our results...

Here you can find the Research Briefing that accompanies our recent article — a quick, accessible overview of the key findings, future directions, and a bit of the story behind the work. 😉 rdcu.be/exPz7

The official website is now open. I’m looking forward to meeting lots of limb researchers in Tokyo 🌸🐓🐀🐟🦎

cscenter.co.jp/limbdev26/

Thank you very much!!

Congratulations! Super impressive work!

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

How to represent genomes in 3D?

In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅

👉🏼 genomebiology.biomedcentral.com/articles/10....

Muchas gracias Álvaro!

Thank you very much Bjort! 😘

Thank you very much Marc! it was both helpful and fun working with you and Alex! ☺️

Muchas gracias!! ☺️

Un estudio revela que las alas de los murciélagos se forman reutilizando programas genéticos ya existentes

La investigación en la que ha participado el @cabd-upo-csic.bsky.social obtuvo datos sobre los programas genéticos que subyacen a cambios morfológicos durante la evolución

t.ly/rMKZt

Flying with hands – The evolution of bat wings

How did the bat get its wings? New research from a collaboration between the labs of Stefan Mundlos (MPIMG), Dario G. Lupiáñez, and Francisca M. Real (@cabd-upo-csic.bsky.social) show how genetic programs were reused during the evolution of mammalian flight. --> www.molgen.mpg.de/news-2025-fl...

Thank you very much and congrats to you too! I just saw your paper 🥳

Thrilled to see our revised preprint now published in Nature Ecology & Evolution!
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!

www.nature.com/articles/s41...

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Range extender mediates long-distance enhancer activity - Nature The REX element is associated with long-range enhancer–promoter interactions.

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

A meme-style comic panel with three parts. Left: A stylized enhancer with a mutation, surrounded by colored blocks representing functional motifs, a neural network diagram, chromatin accessibility signal traces, and a sequence motif. Two cartoon mouse embryos below show different LacZ reporter activity patterns. Top right: A hand hovers anxiously between two red buttons labeled “Experiments” and “AI,” with the caption “HOW DO ENHANCERS REALLY WORK?” Bottom right: A sweating superhero wipes his forehead, looking stressed about the difficult choice.

Textbooks: “Enhancers are just a bunch of TFBSs”

But how do they REALLY work?

New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social

A 🧵 (1/n)

Free access link: rdcu.be/erD22

We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...

Genome-wide demographic analyses of balaenid whales revealed complex history of gene flow associated with past climate oscillation Abstract. The balaenid whale, comprising three species of right whales and the bowhead whale, represents an ancient and highly endangered lineage of marine

Happy to share our latest paper, where we “dive” into the evolutionary history of whale genomes. Check it out for more details!! 🐳🐋🧬

Congrats!!! 👏👏👏

We released our preprint on the CREsted package. CREsted allows for complete modeling of cell type-specific enhancer codes from scATAC-seq data. We demonstrate CREsted’s robust functionality in various species and tissues, and in vivo validate our findings: www.biorxiv.org/content/10.1...

🚨🚨#Hiring!

3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG

📆 Apply by 23rd May 2023

🔗Details below

@sebioldev.bsky.social

Please RT!🙏

DNA-guided transcription factor interactions extend human gene regulatory code - Nature A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by complexes of TFs rather than by individual ones.

Nature research paper: DNA-guided transcription factor interactions extend human gene regulatory code

https://go.nature.com/4j13XRc

Looking for a PhD in sunny Barcelona? ☀️🔬
Our team is hiring a PhD student for the @hologen.bsky.social project!

📅 Deadline: Apr 20
⚠️ READ THE MOBILITY RULE FOR THIS POSITION
🔁 Please, spread the word

All the info here 👉 www.cnag.eu/jobs/phd-stu...

#PhDlife #Genomics #HoloGen #Barcelona

Congrats!! Very nice first post! 🥂