Miranda Marvel

Early epigenetic priming of regeneration studied with a novel transgenic epigenetic reporter Tissue regeneration requires previously differentiated cells to regain developmental plasticity. However, the upstream mechanisms initiating this process remain poorly understood. Here, we leverage a ...

@jimmykjm.bsky.social and @isabellaclsci.bsky.social et al. focus on epigenetic changes during fin regeneration in this preprint:

www.biorxiv.org/content/10.1...

Two great new #Zebrafish preprints from the #WeinsteinLab using a new transgenic that reports epigenetic silencing and activation! Great to study epigenetic changes in vertebrates, and we even did an ENU screen. Excellent work by @mmarvel.bsky.social et al. 🧪
www.biorxiv.org/content/10.1...

Thanks Abhinav!!

Thanks Leanne!!

Thanks Marina!! Congrats on your paper as well! 🔥

Close up of a zebrafish larval body showing depth-coded epigenetic reporter signal in the liver tissues of a ppat mutant zebrafish

It's been a long time coming and I'm super excited to share our new preprint is out: "A novel transgenic reporter to study vertebrate epigenetics". We generated a zebrafish epigenetic reporter and found a fatty liver disease mutant with weird epigenetic phenotypes 👇

www.biorxiv.org/content/10.1...

An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in ...

Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...

Great new work led by @biomarina-vg.bsky.social on zebrafish meninges!

Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn!

Congrats Marina & team on this great work! 🦓🐟🧠

We recently described the Axillary Lymphoid Organ (ALO) in the #Zebrafish. It's on the OUTSIDE of the fish, making it great for imaging! Learn more by checking out our paper in @jem.org rupress.org/jem/article-...

Excited to see our work describing an external immune organ in the #zebrafish published in JEM! Big thanks to Aurora Kraus and @zebrafishmk.bsky.social and all of our other amazing collaborators including @edanfoley.bsky.social @biomarina-vg.bsky.social #WeinsteinLab rupress.org/jem/article-... 🧪

New: @zebrafish007.bsky.social, @zebrafishmk.bsky.social et al. #WeinsteinLab describe a previously uncharacterized external, experimentally accessible secondary lymphoid organ in the #zebrafish located above the pectoral fin. rupress.org/jem/article/...

Well deserved recognition 🎉

Exciting news! We’re thrilled to announce that tapir Yuna gave birth to a rare and endangered Malayan tapir calf Sunday night. The newborn, covered in distinctive white spots and stripes resembling a fuzzy walking watermelon, is only the second tapir born in our 120-year history.

A couple of weeks left to apply to join Development's *Pathway to Independence* programme

Support & mentoring for post-docs on the academic job market

Deadline: January 31

journals.biologists.com/dev/pages/pi...

An amazing #zebrafish research position opportunity with a great lab at NIH, check this out if you're on the job market!

Zebrafish glial-vascular interactions progressively expand over the course of brain development Glial-vascular interactions are critical for the formation and maintenance of brain blood vessels and the blood-brain barrier (BBB) in mammals, but their role in the zebrafish BBB remains unclear. Using three glial gene promoters—gfap, glast, and glastini (a truncated glast)—we explored glial-vascular development in zebrafish. Sparse labeling showed fewer glial-vascular interactions at early stages, with glial coverage and contact area increasing with age. Stable transgenic lines for glast and glastini revealed similar developmental increases, starting at ∼30% coverage at 3 days post-fertilization (dpf) and peaking at ∼60% by 10 dpf, and consistently higher glial coverage in the forebrain and midbrain than in the hindbrain.

And somehow I missed it going live last week 😂 - our #zebrafish glial-vascular paper is available for those finterested! One of the best ways to end 2024 as a #newPI www.cell.com/iscience/ful...

Graphical abstract of the study

Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)

#NewPI achievement unlocked: the first
#obrownlab publication is officially accepted (🍾) about #zebrafish #glia (green) and the vasculature (magenta). Thanks to our reviewers and congrats to all of the lab members! What a great 1st paper experience. Happy #fluorescencefriday ya'll!

Check out this super talented researcher (and a great person to boot) who's on the job market! 👇

Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish The blood-brain barrier (BBB) protects the brain from circulating metabolites and plays central roles in neurological diseases. Endothelial cells (ECs) of the BBB are enwrapped by mural cells includin...

Latest preprint from the lab!

Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish

www.biorxiv.org/content/10.1...

highly detailed dorsal view of three fish with scales and lymphatic vessels shown in different colors with curved bodies as if the fish were swimming. the two fish on the outside are facing downward, and the fish in the middle is facing upward. the left most fish has magenta scales and green lymphatic vessels, the center fish has blue scales and orange lymphatic vessels, and the right fish has green scales and purple lymphatic vessels.

Bones, scales, and lymphatic vessels in juvenile #Zebrafish for #FluorescenceFriday #WeinsteinLab 🧪🔬

🥳 First Yaniv Lab paper to appear on this new platform!! Thanks Baptiste for the shout-out! 🎉

Axons ❤️ ECM

Shamelessly taking advantage of the bluesky migration to share again some of my favorite echinoderm pics 😀🤩

🔽 Acetylated tubulin (nerves and cilia) and phalloidin (muscles) stains in a juvenile sea urchin (Paracentrotus lividus) just after metamorphosis ⭐

And here’s the rest! A list of ECRs in the #zebrafish community 😎 Reach out if you think you should be added 🙏 🧪 go.bsky.app/HwxuHey

We joined the trend of Starter Packs! Check out our (non-exhaustive) list of Group Leaders & Senior Scientists that work with our favorite fishes! #zebrafish go.bsky.app/2cHYybY 🧪

Glad to see so many scientists over here! 😀 Video: 2 day old #zebrafish dorsal aorta - Fish RBC's are nucleated #WeinsteinLab 🧪 🔬

*Tap tap tap* Is this thing on? New paper alert from the lab, featuring first author Dymonn Johnson and a whole host of collaborators who helped this paper come together. We couldn't have done this without the whole team! www.biorxiv.org/content/10.1...

Wishing everyone a happy Pi(e) Day from the #WeinsteinLab 🐟