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Gabriel Bossé

@gabrielbosse.bsky.social

Neurobiology of drug abuse using Zebrafish! @CERVO_ULaval @universitelaval in Quebec City

126 Followers  |  107 Following  |  7 Posts  |  Joined: 04.12.2024  |  1.7196

Latest posts by gabrielbosse.bsky.social on Bluesky

Congrats!

26.06.2025 17:25 — 👍 1    🔁 0    💬 1    📌 0

Thanks for everything you did for this community and navigating an ever changing landscape.

26.06.2025 12:49 — 👍 3    🔁 0    💬 0    📌 0
Figure taken from MacRae & Peterson (2015): How suitable are zebrafish for discovering human drugs? Although zebrafish enable in vivo studies on a large scale, questions remain about how relevant the findings are for drug discovery. Recent studies have begun to elucidate the degree of conservation between humans and zebrafish, which share 82% of disease-associated targets and a large number of drug metabolism pathways (as illustrated by the mass spectrometry of metabolic by-products). Zebrafish physiology is often well conserved (sometimes more so than rodent physiology); for example, cardiac electrophysiology (illustrative electrocardiogram (ECG) tracings from each organism are shown). Several compounds discovered in zebrafish screens have been shown to exhibit similar effects in rodent models and humans, including eight out of ten compounds tested by our groups. m/z, mass to charge ratio.

Figure taken from MacRae & Peterson (2015): How suitable are zebrafish for discovering human drugs? Although zebrafish enable in vivo studies on a large scale, questions remain about how relevant the findings are for drug discovery. Recent studies have begun to elucidate the degree of conservation between humans and zebrafish, which share 82% of disease-associated targets and a large number of drug metabolism pathways (as illustrated by the mass spectrometry of metabolic by-products). Zebrafish physiology is often well conserved (sometimes more so than rodent physiology); for example, cardiac electrophysiology (illustrative electrocardiogram (ECG) tracings from each organism are shown). Several compounds discovered in zebrafish screens have been shown to exhibit similar effects in rodent models and humans, including eight out of ten compounds tested by our groups. m/z, mass to charge ratio.

Due to their aquatic environment, #zebrafish are perfect for small molecule drug screens. Many drugs have been repurposed for novel treatments such as COX inhibitors in leukemia & glucocorticoids in long QT syndrome. For more, read this Nature review ($): doi.org/10.1038/nrd4... #ZebrafishFunFacts 🧪

06.06.2025 14:40 — 👍 18    🔁 7    💬 0    📌 0
Postdoctoral position available in the Breton-Provencher Lab at Université Laval to study neuromodulatory systems and foraging behavior – Canadian Association for Neuroscience

My laboratory at Université Laval in Québec City, Canada, is looking for a postdoc to study how neuromodulatory systems impact cortical processing during foraging behavior. This fully-funded position offers a collaborative environment in a great city. More info👇

can-acn.org/postdoctoral...

02.06.2025 14:59 — 👍 20    🔁 22    💬 0    📌 0

Such a pleasure to discover the Canadian Dev. Bio. community and meet new reasearch groups. It was a privilege to have the opportunity to present our work. #CDBC2025

29.05.2025 21:51 — 👍 5    🔁 0    💬 0    📌 0
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Over the coming weeks, we will unveil the 14 platforms selected as part of our signature Platorm Support Grant program. First up - Canadian Optogenetics and Vectorology Foundry, led by Marie-Eve Paquet and Yves De Koninck in Quebec City tinyurl.com/35ejeaww

13.05.2025 02:03 — 👍 9    🔁 4    💬 1    📌 0
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What a great day of zebrafish research! Thanks to everyone who shared their amazing work at the 3rd CZRC and congrats to our award winners!

08.05.2025 10:30 — 👍 27    🔁 4    💬 2    📌 1

Great opportunity for young scientists!

29.04.2025 12:41 — 👍 2    🔁 1    💬 0    📌 0
Preview
National Letter Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...

Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...

12.04.2025 14:06 — 👍 76    🔁 79    💬 4    📌 13
A rectangular image with navy blue background and bilingual text in all caps coloured pale blue, white, yellow, which reads: We support research. In all 343 ridings.
A white footer includes the logo for CORE-COEUR Coalition for Research Excellence, Coalition pour l'excellence en recherche, a multicoloured mosaic with a partial orange heart and a partial blue heart.

Une image rectangulaire avec un fond bleu marine et un texte en majuscules coloré en bleu pâle, blanc, jaune, qui se lit comme suit : 
On soutient la recherche. Dans les 343 circonscriptions.

Un pied de page blanc comprend le logo de CORE-COEUR Coalition for Research Excellence, Coalition pour l'excellence en recherche, une mosaïque multicolore avec un cœur partiellement orange et un cœur partiellement bleu.

A rectangular image with navy blue background and bilingual text in all caps coloured pale blue, white, yellow, which reads: We support research. In all 343 ridings. A white footer includes the logo for CORE-COEUR Coalition for Research Excellence, Coalition pour l'excellence en recherche, a multicoloured mosaic with a partial orange heart and a partial blue heart. Une image rectangulaire avec un fond bleu marine et un texte en majuscules coloré en bleu pâle, blanc, jaune, qui se lit comme suit : On soutient la recherche. Dans les 343 circonscriptions. Un pied de page blanc comprend le logo de CORE-COEUR Coalition for Research Excellence, Coalition pour l'excellence en recherche, une mosaïque multicolore avec un cœur partiellement orange et un cœur partiellement bleu.

📢 Spread the word, researchers: We can #VoteOnCampus April 13-16. Let's help students #VoteScience🇨🇦 too!

Avis aux chercheur.e.s! 👉Votez sur vos campus du 13-16 avril. Aidons nos étudiant.e.s à #VoterRecherche aussi 🗳️:

www.elections.ca/content2.asp...

#VotonsRecherche #ResearchersVote
#Elxn45

11.04.2025 22:51 — 👍 18    🔁 19    💬 1    📌 1
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3rd CZRC Scientific Meeting Fourwaves - 3rd CZRC Scientific Meeting

It's the last week to register and submit your abstract for the 3rd Canadian Zebrafish meeting!! We would love to see our friends from south of the border attend, too! Registration and abstract submission close on April 18. event.fourwaves.com/3rdczrc/pages

14.04.2025 03:34 — 👍 6    🔁 9    💬 0    📌 2
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🚨 The Ghersi Lab is Hiring! 🚨

If you're passionate about hematopoietic stem cells, developmental biology, and cutting-edge research, I’d love to hear from you. Feel free to share. 🩸🐠

📍 Montreal, Canada
📩 joey.ghersi.hsj@ssss.gouv.qc.ca and Ghersilab.com

10.02.2025 17:49 — 👍 11    🔁 14    💬 0    📌 2
Preview
On vit 23 ans plus vieux grâce aux recherches sur les animaux! | Benoit Dutrizac | QUB | QUB radio Retrouvez On vit 23 ans plus vieux grâce aux recherches sur les animaux! | Benoit Dutrizac | QUB, un média québécois offrant des contenus d'affaires publiques...

On vit 23 ans plus vieux grâce aux recherches sur les animaux! www.qub.ca/balado/benoi...

26.02.2025 15:20 — 👍 0    🔁 0    💬 0    📌 0

It was such a pleasure to be part of it! Congrats again to both of you!

21.02.2025 05:18 — 👍 1    🔁 0    💬 1    📌 0
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Join us in Toronto for the next Canadian Zebrafish Meeting! Registration and abstract submission will open soon.

23.01.2025 19:58 — 👍 22    🔁 17    💬 0    📌 2
Redirecting

The first paper from the lab! What started as a simple comparison between zebrafish lines turned into an analysis of sensorimotor development in zebrafish larvae: doi.org/10.1016/j.bb...

06.01.2025 17:26 — 👍 16    🔁 5    💬 2    📌 1

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