Kim Good-Jacobson

Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...

Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...

Why vaccines matter for children 10 facts about vaccines, child survival and global progress.

Smallpox killed 300 million people in the 20th century. Today? It's completely eradicated thanks to vaccines.

And polio cases are down 99% since 1988, with 20 million people walking today who would otherwise be paralysed.

Learn more about the power of vaccines: bit.ly/3KeJU5w Via @unicef.org

ps Supp Fig 4 shows differential expression of epigenetic regulators in GC B cell subsets, + the unique & overlapping regions marked by H3K27me3, H4K4me3 and H3K79me3.

Understanding the dynamics & interplay of epigenetic regulators, their marks & GC B cell fate is something we are keenly exploring

Great to see this out!
Following on from our earlier work revealing DOT1L was essential for humoral responses, here we determine the importance of H3K79me2 at multiple stages of B cell biology

👏 to Liam for tenaciously driving this study
👏 to collabs incl @sjturn.bsky.social + those not on bsky

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

👏🏼 congratulations!

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...

This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social

Thread below...

B Cells and Plasma Cells: Fundamental and Translational Biology | Keystone Symposia Join us at the Keystone Symposia on B Cells and Plasma Cells: Fundamental and Translational Biology, March 2026, in Keystone, with field leaders!

Working with a great team to organize @keystoneSymposia.bsky.social #BCells & #PlasmaCells : Fundamental & Translational Biology, this March! Join us to explore emerging research in Keystone! keysym.us/KSBCells26 #KSBCells26

Are you an immunologist working towards your first R01?

Please join @aai.org and take advantage of programs like our Grant Review for Immunologists Program www.aai.org/Careers/GRIP

We pair early career principal investigators with established mentors. Send me a chat for more info

🔬🌍
If you are a 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁 who wants to help others while traveling,𝗗𝗼𝗰𝘁𝗼𝗿𝘀 𝗪𝗶𝘁𝗵𝗼𝘂𝘁 𝗕𝗼𝗿𝗱𝗲𝗿𝘀 needs you!

www.orthosurgeon.msf.org/en/job/micro...
#hiring @msf.ca #microsky #sciencesky #AMR

What a great day; lots of fantastic discussions and a lovely location to boot!

Thank you for hosting me!

I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz

International speaker alert! International speaker alert!

Excited to host @kimljacobson.bsky.social after the Keystone conference in March @lunduniversity-med.bsky.social @lundstem.bsky.social! #Bcells #LundImmunoTalks
lit.blogg.lu.se/2025/02/13/i...

Noted! Although that may have also happened with the characters in LM 😂

Ok bluesky - I want to finally get through one of these dust collectors during the Aussie summer… any recommendations of which to choose?

Closest I’ve gotten to W&P is reading Anna Karenina… and closest to I’ve gotten to LM is enduring the movie 🙃

Photo of the Vinuesa lab members by the sea.

Hi 👋🏼 The Vinuesa lab has arrived at BlueSky! Follow us if you want to talk about all the exciting science going on in autoimmunity, genetics, and anything B cell-related 🧬 🧪

I’ve tried to put together a starter pack of immunologists/scientists exploring B Cell Repertoires and Antibody Affinities.

Please feel free to share/join!

go.bsky.app/4P64DmM

Congratulations Danika!!

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

go.bsky.app/QSEPDoj

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells - Nature Immunology PD-1 is commonly associated with inhibitory functions, yet it is highly expressed in follicular T cells. Shlomchik and colleagues find that PD-1 signaling in germinal centers is necessary for long-liv...

This study is a tour de force by Masato and Koji using rare samples from immunodeficient patients... and nicely complements our previous in vivo data (from my time in the Shlomchik lab) www.nature.com/articles/ni....

It's great to see this out in Immunity today!
Masato Ogishi, Koji Kitaoka, Jean-Laurent Casanova, Stuart Tangye on memory B cells in patients with PD-1 immunodeficiency

Also stoked to contribute unpublished recall response data from my postdoc a very long time ago 🙂

www.cell.com/immunity/abs...

Applying cellular recording technologies to immune cells with @jshendure.bsky.social is a focus of the #SeaHub and the most fun kind of collaborative effort. @cziscience.bsky.social @alleninstitute.bsky.social 🤓

The consequences of SARS-CoV-2 within-host persistence Nature Reviews Microbiology - In this Review, Sigal et al. explore SARS-CoV-2 persistence mechanisms, the frequency of persistent infections, their role in accelerated evolution and their link to...

The consequences of SARS-CoV-2 within-host persistence

SARS-CoV-2 causes an acute respiratory tract infection that resolves in most people in less than a month.What if it does not?

www.nature.com/artic...
1/4

I must admit that this annotated Nature abstract remains a useful recipe for constructing a summary paragraph. I show it to my students every time we get started.

Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy Competition among JAKs for receptor binding may underlie cell type–specific differences in cytokine signaling.

#TheMoreTheMerrier! Zoler, Meyer, Schreiber &co show @ Science Signaling that the type I interferon receptor IFNAR can promiscuously bind multiple JAKs affecting downstream signaling & competing with other cytokine receptors! doi.org/10.1126/scisignal.adl1892

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network

Below are the links

If you're an immunologist and I have missed you so far, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

🗣️The federal Health Minister Mark Butler will speak at the Parliamentary Friends of #MECFS meeting 18th Nov

👩🏻‍💻 Pls join event via zoom to ⬆️ attendee numbers
🗳️ Politicians notice numbers
🛌Cameras can be off to allow resting

Click on link to join zoom
tinyurl.com/2zt7wbas