Hannah Stacey

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.

After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.

* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

🚨 New preprint! We show that intranasal FluMist vaccination induces local HA-specific memory B cell responses in the upper airway, even in the absence of strong systemic responses. Investigating local immunity will be key to designing improved vaccines for respiratory pathogens.