EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS

go.bsky.app/6bWDSjT

A must-have for all #Pathsky Pathologists (and please add me, too)

Like ‘old Twitter’: The scientific community finds a new home on Bluesky After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

“Bluesky has rapidly emerged as the new online gathering place for researchers and scientists.”
#bluesky #medsky #pathsky #scientists #scientificcommunity

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The latest WHO Classification divides these endometrial stromal neoplasms into four distinct groups:
- Endometrial Stromal Nodule
- Low-Grade Endometrial Stromal Sarcoma (LG-ESS)
- High-Grade Endometrial Stromal Sarcoma (HG-ESS)
- Undifferentiated Uterine Sarcoma (UUS)

Monotonous oval to spindle cells with minimal cytologic atypia, often demonstrating whorling around blood vessels

LVI

H&E, CD10, ER, PR

Low-Grade Endometrial Stromal Sarcoma (LG-ESS), uterus: Proliferative-phase endometrial stromal-type tumor cells with “tongue/finger-like pattern” of myometrial invasion, frequent LVI - CD10, IFITM1 & ER/PR positive!
#pathology #pathsky #gynpath #oncsky #sarcoma #lgess #surgicalpathology #pathart

The latest WHO Classification divides these endometrial stromal neoplasms into four distinct groups:
- Endometrial Stromal Nodule
- Low-Grade Endometrial Stromal Sarcoma (LG-ESS)
- High-Grade Endometrial Stromal Sarcoma (HG-ESS)
- Undifferentiated Uterine Sarcoma (UUS)

I haven’t seen a #pathsky starter pack yet! I’ve tried to keep up with all of the new pathologists joining, but I know I have missed many! Please tag yourselves/others below and I will follow them and add them 😁 @kmirza.bsky.social @clilleymd.bsky.social @brettkurpiel.bsky.social go.bsky.app/6bWDSjT

Score 0, 1+, 2+, 3 by IHC of a breast carcinoma

The human epidermal growth factor receptor 2 (HER2), one of the most common biomarkers assessed by scoring of IHC-stained tissue: Overexpressed in 15-25% of breast carcinomas (likely to respond to HER2 targeted therapy) #biomarkers #oncology #Her2 #breastcancer #pathology #surgicalpathology #pathsky

The finger is the most frequently involved anatomic location for the classic (sporadic) glomus tumor.

Glomus Tumor, index finger, H&Es, 10x, 40x & 100x and immunostains - Composed of 3 components:
1. Glomus cells
2. Vasculature
3. Smooth muscle cells
Vimentin, SMA, h-caldesmon & CD34 positive and CKs & S100 negative!
#pathology #pathsky #softtissuepathology #glomustumor #surgicalpathology #pathart

The finger is the most frequently involved anatomic location for the classic (sporadic) glomus tumor.

go.bsky.app/MW6yavV

Hi! Can you please add me to this starter pack? Thank you!

A starter pack for people living, working, treating, studying kidney cancer #kidneycancer #kcsm #renalcellcarcinoma #RCC, please share and suggest

go.bsky.app/JGYhGhd

Androgen receptor immunohistochemical stain

Salivary Duct Carcinoma (SDC), parotid, H&Es,20 & 40x, AR and PAP smears: Aggressive salivary gland adenocarcinoma, abundant eosinophilic (oncocytic) cytoplasm and AR, GATA3 & GCDFP15 positive!
#pathology #pathsky #surgicalpathology #headandneckpathology #cytosky #salivaryductcarcinoma #sdc #pathart

Serous cystadenoma, pancreas, H&Es, 20x, 40x, 100x & DQ/PAP smears: Intracystic/intraluminal papillary projections lined by bland flattened to cuboidal epithelium - EMA, MUC1, inhibin, GLUT1 positive!
#pathology #pathsky #surgicalpathology #cytosky #pancreaticpathology #serouscystadenoma #pathart

Ameloblastoma (follicular type), mandible, H&Es, 20x and 40x: Epithelial nests with a peripheral layer of columnar cells showing "palisading" and "reverse polarity", surrounding a central area resembling the “stellate reticulum” of a developing tooth! #pathology #pathsky #surgicalpathology #pathart

CD68 immunohistochemical stain

S100 immunohistochemical stain

Granular cell tumor (GCT), tongue, H&Es, 10x and 40x & CD68 and S100, 20x: Large round to oval tumor cells with indistinct eosinophilic, granular cytoplasm - CD68, S100, and SOX10 positive!
#pathology #pathsky #surgicalpathology #granularcelltumor #gct #headandneckpathology #pathart

Cytokeratin 7 immunohistochemical stain

Chromophobe renal cell carcinoma (ChRCC), kidney, H&Es, 20x and 40x, CK7, 20x: Plant-like tumor cells - Vimentin negative; CK7 and C-Kit positive!
#pathology #pathsky #surgicalpathology #renalpathology #renalcellcarcinoma #renalpathology #RCC #kidneypathology #ChRCC #pathart

‘Starry sky’ appearance of Burkitt lymphoma, here involving testicle

#pathsky #medsky #pathology #hemepath

Pulmonary Blastomycosis, BAL, Pap stain, 40x and GMS stain, 40x: caused by Blastomyces dermatitidis spores, broad-based budding yeasts with thick, refractile cell walls!
#pathology #pathsky #cytopathology #cytosky #lungpathology #blastomycosis #pulomonaryblastomycosis #microbiology #pathart #cytoart

Invasive Micropapillary Carcinoma (IMPC), breast, H&E, 10x and 40x: Mimics lymphovascular space invasion due to “empty/clear spaces” around the tumor cells!
#pathology #pathsky #surgicalpathology #breastpathology #invasivemicropapillarycarcinoma #IMPC #pathart

Microglandular adenosis (MGA), breast, H&E, 10x and 40x: A rare breast lesion! #pathology #pathsky #surgicalpathology #breastpathology #microglandularadenosis #MGA

#pathology #pathsky #surgicalpathology #breastpathology #lobularneoplasia #ALH

#pathology #pathsky #surgicalpathology #pathart #colonicadenocarcinoma

Atypical lobular hyperplasia (ALH), breast, H&E, 40x

Atypical lobular hyperplasia (ALH), breast, H&E, 40x

Poorly differentiated colonic adenocarcinoma, H&E, 20x