Rajan Singh

Fig. 1: Neurobiotic sense of feeding control.

DECEMBER ISSUE |NEWS & VIEWS "A neurobiotic sense curbs feeding: a new frontier in gut–brain communication"

www.nature.com/articles/s41...

#Gastrosky

Our December issue is out! #liversky #gastrosky.

Featuring a great cover by Richard Tibbitts inspired by the ‘Jekyll and Hyde’ roles of memory T cells

⏩#GLP1 #Serotonin, the body’s multitasking maestro #DGBIs💡 🎯A blueprint for developing #orally active small-molecule secretagogues capable of activating the body’s own incretin sensors & gut-brain axis👏 📢The advent of GLP-1–based therapies has reshaped modern metabolic medicine, providing unprecedented efficacy in treating diabetes and obesity. Yet, these advances rely heavily on injectable hormone mimetics #semaglutide #tirzepatide 🎯Transform EC and L cells into tunable therapeutic switches—enabling mechanism-based, physiological treatments for diabetes, obesity, and disorders of gut–brain communication‼️ 🎯Through #neuropod synapses, EECs transmit real-time information about nutrient composition to the brain—forming a crucial component of #interoception, the body’s sense of internal state 🎯A detailed map of human enteroendocrine cell function & receptor signaling—laying the foundation for oral therapies that stimulate endogenous hormone secretion🌟 ⏩Description and functional validation of human enteroendocrine cell sensors @ScienceMagazine👏 👉 https://www.science.org/doi/10.1126/science.adl1460

Dive deep into our latest #GastroDigest @aga-gastro.bsky.social 🆕🔥
🚨Turning #GutSensors into Therapeutic Switches: A #Sensorome Roadmap for Metabolic & Gut–Brain🧠Interaction Disorders‼️ @amergastroassn.bsky.social 🙌
Prof. Kara Margolis🙏😇
👉 www.gastrojournal.org/article/S001...
#DGBI #GLP1 #Serotonin

Gut–brain communication: types of sensory nerves and mechanisms of activation Nature Reviews Gastroenterology & Hepatology, Published online: 28 October 2025; doi:10.1038/s41575-025-01132-1This Review explores the different types of sensory nerves involved in gut–brain communication, detailing the locations of these nerve endings in the gut and their mechanisms of activation. Insights and new information regarding spinal and vagal afferents alongside viscerofugal neurons are detailed.

New online! Gut–brain communication: types of sensory nerves and mechanisms of activation

Proteases in intestinal health and disease Nature Reviews Gastroenterology & Hepatology, Published online: 20 October 2025; doi:10.1038/s41575-025-01129-wIn this Review, Deraison and Vergnolle describe the role of extracellular proteases and protease inhibitors in gastrointestinal physiology and in diseases including inflammatory bowel disease, irritable bowel syndrome and colorectal cancer. They also explore emerging therapeutic options for restoring proteolytic balance.

ICYMI: New online! Proteases in intestinal health and disease

A neurobiotic sense curbs feeding: a new frontier in gut–brain communication Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

ICYMI: New online! A neurobiotic sense curbs feeding: a new frontier in gut–brain communication

A neurobiotic sense curbs feeding: a new frontier in gut–brain communication Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

New online! A neurobiotic sense curbs feeding: a new frontier in gut–brain communication

🆕🔥The Path Forward: Assessing a Pilot Competency-Based Curriculum on #DGBIs for Gastroenterology Trainees‼️ #NGMJournal
👉 onlinelibrary.wiley.com/doi/10.1111/nm…
✅DGBI education curriculum
✅Pre-&Post-individual knowledge scores
🎯Attitudes in managing DGBIs👏
#ANMSociety #ESNM

We are excited to announce the launch of our new podcast highlighting the latest in Gastropsych research. Our first episode features an interview with Dr. Sarah Ballou.

Find us on Spotify spotifycreators-web.app.link/e/e5BnWaqDPTb

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

Gene editing treatment helps desperately ill baby thrive. This brings real hope for countless others.

A win for US investment in science.

www.nytimes.com/2025/05/15/h...

Ever noticed your crying baby quiets when you carry them? It’s an evolutionary response.

Both infants and mice pups reduced crying, and lower heart rate when carried compared to being held while sitting.

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🆕🔥#NeuroGastroMotil
#Sex-specific alterations in intestinal neuronal-epithelial interactions between #CGRP & #Goblet cells secondary to elevated enteric #AlphaSynuclein potentially contribute to GI dysfunction in #Parkinson's Disease‼️
👉
onlinelibrary.wiley.com/doi/10.1111/nm…
#ANMSociety #ESNM

#04: Professor Alex Ford - Navigating disorders of gut-brain interaction and IBS Podcast Episode · Two guys talking **it - A Gastroenterology and Hepatology podcast · 22/01/2025 · 1h 11m

A must-listen for anyone working with people with DGBI 👇🏼 Great summary and experience from Alex Ford podcasts.apple.com/au/podcast/t...

Love Thy Neighbor? Exploring Gastroenterology Attitudes Toward Endometriosis Screening - PubMed Endometriosis is a chronic painful condition affecting 10% of reproductive-aged women with a high prevalence of overlapping gastrointestinal symptoms. There is a significant diagnostic delay for endom...

And the prize for best title in GI goes to:

Love Thy Neighbor: Exploring Gastroenterology Attitudes toward Endometriosis Screening

@drlauriekeefer.bsky.social
@drmadisonsimons@bsky.social

pubmed.ncbi.nlm.nih.gov/39570538/

⏳ How to Break Bedtime Procrastination

📵 Limit blue light
⏰ Set a “wind-down” alarm → A cue to start relaxing.
🎧 Swap scrolling for audio → Podcasts or music help detach.
🌿 Consider melatonin
🔁 Stick to a schedule → Consistent bed & wake times regulate your body clock.

5 things I did this week to contribute to society:

1. Staid home when sick to protect others
2. Random acts of kindness as they tend to multiply
3. Recycled, to protect this earth
4. Donate/volunteer to give back to others
5. Shared evidence based health information to counteract misinformation

🎯#Practical approaches to managing gastroparesis👏 #BMoshiree #joytorious #DoerflerBethany #MichaelCline🎉 ✳️Choice of therapy in gastroparesis based on possible #pathophysiolocal correlates ✅Dietary management ⏩#Nutrient drinks commonly used in gastroparesis👏 🎯Healthy diet & tips to reduce particle size in gastroparesis💡 🎯Red flags for disordered eating behaviors 🎯Alternate diagnoses to gastroparesis✨ #ViceralHypersensitivity #PyloricDysfunction #ImpairedGastricAccomodation #DecreasedAntralContractility #VagalNerveDysfunction⚡️

🚨The Red Section: How I Approach it
✅The Management of #Gastroparesis Symptoms‼️
@amcollegegastro.bsky.social 🆕🔥
🎯Practical approaches to managing gastroparesis👏
✳️Choice of therapy in gastroparesis based on possible #pathophysiolocal correlates
✳️Dietary management👏
👉
journals.lww.com/ajg/citation...

• Evidence is building for mind body medicine in gut diseases. • Yoga, meditation and hypnotherapy may be beneficial because they create a deeply focused state of attention while introducing ideas or suggestions that encourage positive change. • More studies are need to examine the overlapping and shared mechanisms of mind-body approaches.

🆕🔥Yoga, Meditation, Mindfulness, or Hypnotherapy for GI disorders: Similar Mechanisms of Action?
🎯Evidence is building for mind body medicine in gut diseases‼️ @drvantilburg.bsky.social
✅Yoga, meditation & hypnotherapy may be beneficial for GI disorders👏
👉 onlinelibrary.wiley.com/doi/full/10....

Thank you @rajansingh.bsky.social and all the faculty and grad students at @unevadareno.bsky.social who invited me to give a talk, and for many memorable meetings and chats!!

See who is here today #UNRMed
Dr. Subhash Kulkarni @klab.bsky.social 🙏
What an amazing talk on Age-associated gut dysmotility-linking development to aging👏
🎯ENS plasticity-Replacing the ENS through neurogenesis
So much learning in the field😇
Thanks a bunch for sharing ENS insights #Halloween mouse🔥

Excited share that our @romefoundation.bsky.social Working Team's manuscript 📄 on Overlap in Disorders of Gut-Brain Interaction #DGBI is now published in @natrevgastrohep.bsky.social! Grateful for this amazing journey with global experts. Read here: nature.com/articles/s41...
#DGBI #GISky #GutSky

🌟 Recognizing #DGBI in patients with organic GI disease remission prevents overtreatment with risky drugs and ensures targeted care. Let’s focus on better outcomes! 👉 bit.ly/3Ee3iwv #GISky #MedSky #GutSky

Honoured but a bit sad to be giving the Inaugural Gary Mawe Memorial Lecture in @uvmvermont.bsky.social tomorrow. It will be strange to be in Vermont without Gary… a giant if Neurogastroenterology gone far too soon…

Have a kid with a sweet tooth? It may be their gut microbiota steering their cravings.

A recent study found a complex, bidirectional relationship between marital quality and #DGBI symptoms in married Malay women. These findings underscore the importance of considering psychosocial factors when treating women with DGBIs.

A recent study found a complex, bidirectional relationship between marital quality and #DGBI symptoms in married Malay women. These findings underscore the importance of considering psychosocial factors when treating women with DGBIs.

Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study In a population-based case-control study, Raphael Peter and colleagues investigate the clinical characteristics and diagnostic findings in patients with post-COVID-19 syndrome.

Long #COVID symptoms persists for at least 2 years, study finds. Not great news for many sufferers.

journals.plos.org/plosmedicine...

I've been on Bluesky for a while now, waiting for a starter pack to bring the #DGBI community together. Since none existed, I decided to create one myself! The DGBI Starter Pack is here to help us connect, share, and grow together. Join us and make gut health a priority! 🌐🌱 #GISky #GutSky #IBS #FGID

Highlights • Metagenome-informed metaproteomics (MIM) concurrently assesses diet, host, and microbiome • MIM distinguishes compositional from functional dysbiosis in multiple disease contexts • MIM links host IBD cues to commensal suppression and uncovers trans-kingdom biomarkers • MIM gauges IBD-related dietary shifts, EEN compliance, and small intestinal malabsorption ⏬Dive into to learn more about how dietary-bacterial-host metagenome-informed metaproteomics #MIM assessment functionally uncovers trans-kingdom interactomes shaping #GI ecology while offering #personalized diagnostic & therapeutic insights into #MicrobiomeAssociatedDisease💡 🎯#IPHOMED (Integrated Proteo-genomics of HOst-MicrobiomE-Diet) may contribute to the decoding of the pathogenesis of microbiome-associated diseases, while unveiling promising diagnostic and therapeutic opportunities👏 ✨Benchmarking⏩In vitro, In silico, & In vivo #Disease compliance #Disease biomarkers #Therapeutics targets #Antibiotics💊 perturbation🙌

🚨Utmost importance the food we eat & the #GutMicrobiota
we have🔥
Fascinating study #CellCellPress 🆕
🎯#Metagenome-informed metaproteomics of the human #GutMicrobiome,🦠 host, & #dietary exposome uncovers signatures of #health & #InflammatoryBowelDisease‼️
👉 www.cell.com/cell/abstrac...
#IPHOMED #IBD

Congratulations to the 2025 #ACGInstitute Leadership Program cohorts! 🎉 Excited to see such a diverse group of future leaders shaping the field of gastroenterology. Leadership YOU in DC sounds like an incredible opportunity for growth and collaboration. 👏👏