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What if pediatric T-cell leukemia isn’t just one disease, but many?

New study reveals 15 genomic subtypes of pediatric T-ALL, transforming risk assessment and treatment! Read more: ashpublications.org/...

Clinical metagenomics for diagnosis and surveillance of viral pathogens Nature Reviews Microbiology, Published online: 13 August 2025; doi:10.1038/s41579-025-01223-5Metagenomics approaches are being increasingly used for the diagnosis of viral infections, outbreak investigation, and new and emerging pathogen surveillance. This Review highlights sequencing approaches and technologies, discusses their applications in diagnostics, surveillance and virus discovery, and outlines future perspectives for the field.

New online! Clinical metagenomics for diagnosis and surveillance of viral pathogens

This tiny device can shrink dangerous blood clots. It’s called the ‘milli-spinner’ and its invention was partly an accident…

From period pain to heart disease, the gender health gap is real – here’s how to close it Millions of women live with delayed diagnoses, dismissed pain and inadequate care. Now, progress is at risk of reversal.

Millions of women live with delayed diagnoses, dismissed pain and inadequate care. Now, progress is at risk of reversal.

On this day in 1863, Harriet Tubman's forces freed more than 700 slaves in a raid of South Carolina plantations .

mississippitoday.org/2025/06/02/o...

Bacteria-killing paint could dramatically improve hospital hygiene – Physics World A novel antimicrobial coating can be applied to a range of surfaces to destroy bacteria and viruses

An antimicrobial coating can be painted onto a range of surfaces to continuously destroy bacteria and viruses. 🧪⚛️ physicsworld.com/a/bacteria-k...

bsky.app/profile/hrw....

It is so normalized that I hear it regularly among average to highly informed and scientifically minded people.

In most cases it's something akin to: "seems the most likely" and "well, that one turned out to be true".

It's mind boggling 🤯

"die Not im Gazastreifen" - Ja, so kann man einen Völkermord natürlich auch nennen.

Ich frage mich ja, wer für diesen wohl verantwortlich ist und welche Mittäter dies unterstützen?

Within the last hour - the Senate hearing is ongoing.

AE1/AE3

#PathSky Right femur lesion in an older woman. Diffusely keratin-positive with 3 different antibodies.

The biopsy from this adult kidney transplant recipient shows features of cytomegalovirus (CMV) infection, including prominent enlargement (“cytomegalo-”) of tubular epithelial cells and their nuclei, along with small basophilic inclusions which expand the cell cytoplasm.

#renalpath #kidneypath

"It’s like I’m surrounded by an electric fence that will trigger a bad day if I touch it. But the fence is invisible, and moves every day."

Excellent article about the stigmatization of ME/CFS and its deep roots in misogyny female-biased diseases regularly encounter.

#LongCovid #ME/CFS

Prompt: "A funky fungus that evokes slight trypophobia"

Sir David Attenborough laying in the sand next to a turtle.

Sir David Attenborough laying on the ground next to a group of puffins.

Sir David Attenborough laying on the ground next to a group of meerkats

Sir David Attenborough laying on the ground next to two gorillas.

Happy 99th Birthday to Sir David Attenborough!

Joyfully showing the beauty of the planet we live on and share with others. Always educating on the complex ecological interactions it relies on.

A legend - here seen in his natural habitat: on the ground next to one of world's beautiful creatures 🌍

Public health is part of healthcare - they are inseparable.

It's in the language and the research - or often the lack thereof - of women's health. One more great example why diversity in science matters! 🧪

Very interesting read. Here's a link for all without a subscription:

archive.is/Duh33

A resurrected defence of beanbag genetics | Aeon Essays Today a bitter dispute about the nature of biology is underway. A simple bag of beans may be what tips the balance

A resurrected defence of beanbag genetics – aeon.co/essays/a-res...

Lysozyme nephropathy
•Rare cause of AKI in monocytic leukemias
•Proximal tubules have hypereosinophilic granular cytoplasm, which are PAS +/- & silver➖
•IHC stain: lysozyme strongly➕in cytoplasm
•EM:⬆️# of lysosomes with electron dense stuff
#renalpath #nephsky, #pathsky #medsky

Non-invasive pressure sensor could revolutionize how brain injuries are diagnosed – Physics World Panicos Kyriacou of UK-based Crainio is our podcast guest

Rapid measurement of intracranial pressure is crucial to the treatment of traumatic brain injury. A new non-invasive sensor could help, explains Panicos Kyriacou in this podcast. 🧪⚛️ ow.ly/23Nk50Vy6Z1

The best part is that they just use their own definition of 'species' and call it a day.

Remarkably, relying mainly on morphology became obsolete due to the rise in genetic sequencing - something Colossal should be familiar with.

Yes, unfortunately. There might be valuable research in there but this project is mainly driven by headlines = $$$.

While there are disagreements on where the speciation line is in some cases, this statement by the CSO is deeply unserious.

A species is whatever we want it to be, so everyone is correct 👏🏼

This short interview by the New Scientist gets to the crux of the whole thing pretty well.

www.newscientist.com/article/2475...

#colossal #direwolf #evolutionarybiology #deextinction

Brightens up my day every time to see those happy endings 🥰

Thyroid FNA #1 of 2:

What is your interpretation?

A) Benign
B) Follicular neoplasm
C) Malignant
D) Non-Diagnostic
#Thyroid #CytoPath #Pathology #PathSky

Itacitinib for prevention of graft-versus-host disease and cytokine release syndrome in haploidentical transplantation Key PointsItacitinib with haploidentical transplantation, when added to standard GVHD prophylaxis, was well tolerated without impairing engraftment.Itaciti

Itacitinib improved patient outcomes after haploidentical transplantation, reducing severe complications and achieving an 80% one-year survival rate.

by Abboud R, Schroeder MA (...) DiPersio JF et 16 al. in Blood #MedSky

📖 read the article:

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...

Challenging cases of light chain proximal tubulopathy. Only real clue was eosinophilia of proximal tubular cytoplasm. Crystals essentially invisible on LM (including tol blue); only few proximal tubules on EM with focal crystals. Glad I did the pronase IF. #renalpath #pathsky #nephsky

Roman-era battlefield mass grave discovered under Vienna football pitch Archaeologists say ‘catastrophic military event’ took place at site where 129 bodies have been found so far

A Roman era battlefield mass grave found from Vienna #Archaeology
www.theguardian.com/world/2025/a...

Very timely research 💉

#vaccines #misinformation #diseasecontrol #medsky