Simon Snoeck

β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling Nature Communications - Using AI-based structural modeling, the authors reveal the ligand-binding and subsequent receptor complex formation mechanisms of three LRR-RP-type plant PRRs and propose a...

Much like the Island Domain shifting its shape, our preprint has transformed too @natcomms.nature.com rdcu.be/eTOhF

09.12.2025 09:01 — 👍 10    🔁 5    💬 0    📌 0

By the @cellsensing.bsky.social and Zipfel labs: The plant receptor kinase HSL3 senses a cyclic, disulfide-bond stabilized peptide phytocytokine. www.biorxiv.org/content/10.1...

25.10.2025 07:19 — 👍 28    🔁 16    💬 0    📌 0

Is my bike a Fabaceae? San Bernardino pass, wowie!

01.08.2025 06:48 — 👍 1    🔁 0    💬 0    📌 0

*Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism.

09.07.2025 12:52 — 👍 0    🔁 0    💬 0    📌 0

Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism. www.biorxiv.org/content/10.1...

09.07.2025 11:45 — 👍 28    🔁 15    💬 1    📌 0

Exclusive: Famed protein structure competition nears end as NIH grant money runs out Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold

Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.

04.07.2025 12:06 — 👍 63    🔁 45    💬 0    📌 3

MIK2 clade receptor function in perception of a Fusarium-derived elicitor is conserved among different plant families https://www.biorxiv.org/content/10.1101/2025.05.22.655486v1

23.05.2025 12:03 — 👍 6    🔁 5    💬 0    📌 0