Joe Curran

Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme Nature Chemistry - Models of abiotic RNA replication suffer from inherent product inhibition arising from the high stability of RNA duplexes. Now, it has been shown that RNA trinucleotide...

New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.

The latest preprint from our lab is out! 🎉 A phosphoproteomic adventure into how different phosphatases counteract CDK activity and how this can help to order substrate phosphorylation during the cell cycle. Find out more from first author, and my PhD lab partner in crime @theresazeisner.bsky.social

A map of the rubisco biochemical landscape - Nature A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible, signposting further e...

Every synthetic biologist, every biochemist, when they dream, will sometimes hear a voice calling

A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods

"...engineer RuBisCo..."

And this paper takes us one step closer
www.nature.com/articles/s41...

Hi #SciSky! It’s exciting to see that we’ve reached a critical mass and it’s all kicking off here. Looking forward to finding out about lots of cool science