Mel Eckersley-Maslin

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇

We’re looking for the next Metcalf Prize winners – up-and-coming researchers with big ideas. Two prizes worth $60,000 each will be awarded to one male and one female mid-career stem cell scientist. Nominations close 11 August. Please share widely: www.stemcellfoundation.net.au/metcalf_prizes

🚨 Abstract deadline extended!
You’ve got a little more time to submit for #ASSCR2025 🧬
📅 New deadline: Friday 15 August 11:59pm.
Don’t miss your chance to share your science at the Gold Coast! 🌊🌴
👉 lnkd.in/eqmcBi9Q
#StemCells #CallForAbstracts

Applications for prizes are also due on 15th August.

Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks - Genome Biology Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enha...

🚨 New paper alert 🚨
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵

Applications for two $60,000 #MetcalfPrizes for Stem Cell Research Are now open.
Do you know a rising star of Australian stem cell science? Encourage them to apply.
Please share widely. #MetcalfPrizes
stemcellfoundation.net.au/metcalf_prizes

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...

The Chromatin And Development lab are hiring a postdoc!

Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!

lms.mrc.ac.uk/work/vacanci...

Postdoc post in my lab from Autumn this year @lsiexeter.bsky.social @exeter.ac.uk
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!

I am recruiting for a postdoc in my lab at @blizardinstitute.bsky.social @qmulepigenetics.bsky.social to work on explainable AI/ML and epigenetics with a focus on enhancers. 3-year BBSRC funded position. A collaboration with @a-radzisheuskaya.bsky.social
qmul-jobs.tal.net/vx/mobile-0/.... Pls share.

On today!! Looking forward to catching up with the Melbourne Epigenetics community (and out of town friends) and hearing some great science!

Only 2 days left to apply for our ECR travel awards!! 🛬

Applications close at 5pm AEST Friday 13th June.

Note: You must be an ECR member to apply. T&Cs and application form are on our website www.aepia.org.au/conference-t...

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...

Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬:
www.biorxiv.org/content/10.1...

🧵 below

Predicting expression-altering promoter mutations with deep learning Only a minority of patients with rare genetic diseases are currently diagnosed by exome sequencing, suggesting that additional unrecognized pathogenic variants may reside in non-coding sequence. Here,...

Huge thanks to Illumina, Kyle Farh, Nicole Ersaro, Gherman Novakovsky, and the entire team behind PromoterAI for making this happen. Full paper: www.science.org/doi/10.1126/...
@science.org (10/)

PhD Student at the IOR - Institute of Oncology Research in Bellinzona, Switzerland The Institute of Oncology Research (IOR) The IOR, affiliated with the Università della Svizzera italiana (USI), is located in a brand-new, high-tech research building that hosts more than 20 differ

📣 Join us! Were looking for a PhD student to join our lab and work on human pluripotent stem cell (hPSC)-based models of the peripheral nervous system and disease. Come be part of our supportive and dynamic lab family in the beautiful Bellinzona, Southern Switzerland 🇨🇭☀️⛰️ ior.usi.ch/events-news/...

"Thinking time —the time needed to concentrate without interruptions has always been central to scholarly work. It is essential to designing experiments, compiling data, assessing results, reviewing literature and, of course, writing. Yet, [it] is often undervalued."
www.nature.com/articles/d41...

If you love #chromatin and are in Melbourne on 18th June, join us for the next Melbourne Epigenetics Club!

Featuring Tim Johanson, Conny Bonifer and Brent Thomson @dtgenomics.bsky.social, followed by networking reception

Free event but registration essential www.eventbrite.com.au/e/5th-melbou...

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

Stunning location for next stop of my Europe tour- the GRC cancer genetics and epigenetics conference. Thoroughly enjoying all the science presentations so far!

One of my favourite parts of this Europe trip has been catching up with former students @nchoy.bsky.social (now intern with @robertife.bsky.social) and @elisakre.bsky.social (now pdoc with @priscaliberali.bsky.social). It’s so great to see you both doing so well!

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISP...

www.science.org/doi/10.1126/...

Make your future Melbourne Lead the next wave of biomedical discovery

🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery.

For more information and to apply 👇

LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding…

A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @cellpress.bsky.social and available through @jacksonlab.bsky.social www.sciencedirect.com/science/arti...

First time back in Europe since establishing the lab in Australia in 2021. First stop #EMBLChromatin!

Stop by poster 200 or find me at coffee if you want to discuss Janith’s recent work on what happens when embryonic chromatin regulators are hijacked in cancers

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...

🚨 Preprint 🚨
Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens!

doi.org/10.1101/2025...

Australia should be doing this now and at a grander scale. Let’s reverse the brain drain and properly support the scientists we have @markbutlermp.bsky.social @edhusicmp.bsky.social

🚨 Registration open for ASSCR EMCR Symposia 2025 – FREE for members!
🎟️ Limited to 100 spots

📍NSW: June 27 (Abstracts due May 22)
📍VIC: July 3 (Abstracts due May 29)

👉 Register: www.eventbrite.com.au/cc/2025-assc...
#ASSCR2025 #EMCR #StemCells

Embryonic stem cell factors DPPA2/4 facilitate a unique chromatin state in non-small cell lung cancer Embryonic regulators are often re-expressed in cancers, however the functional and molecular significance of this is not always understood. The epigenetic priming factors Developmental Pluripotency As...

Read the paper here! www.biorxiv.org/content/10.1...

Congrats to Janith and the rest of the lab @petermaccc.bsky.social, and thanks to collaborators Shabih Shakeel @wehi-research.bsky.social, @benparkerlab.bsky.social and @burrlab.bsky.social, and ongoing support from @snowmedical.bsky.social
(6/6)

This raised a key Q: How can you have PRC1-deposited H2AK119Ub without PRC2-deposited H3K27me3?

At many of K4-K119Ub sites, PRC2 is present, but high levels of H3K27ac is likely preventing its catalytic activity. If we forcefully remove H3K27ac, now H3K27me3 accumulates, silencing the genes. (5/6)

Many of these DPPA2/4 bound promoters were poised with H3K4me3 and H2AK119Ub, but not H3K27me3. We validated these K4-K199 regions by reChIP, and found DPPA2/4 depletion leads to reduced K119Ub at these sites (4/6)

Proteomics and biochemistry confirmed these proteins physically interact to bind nucleosomes. Interestingly DPPA2 seems to require DPPA4 for its stability (but not vice versa).

We mapped their genome binding sites using both CUT&Run and ChIP - DPPA2/4 bind together at CpG rich promoters (3/6)