So exciting to see ASSCR partner with @isscr.org to support Australasian student and ECR researchers to attend the ISSCR Annual meeting in Montreal!! This Joint Travel Award, the first of its kind, will enable more interactions with the international community for our EMCR members!!
#stemcells
09.02.2026 06:39 โ ๐ 3 ๐ 2 ๐ฌ 0 ๐ 0
New ISSCR-ASSCR joint travel awards to support Australian students and EMCRs to attend @isscr.org annual meeting in Montreal
07.02.2026 23:38 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
Our new preprint on SMCHD1! Weโve shown SMCHD1โs ATPase activity is critical for function in vivo, and excitingly a new DNA binding domain neighbouring the ATPase domain activates the enzymatic function, which is important for normal chromatin binding.
urldefense.com/v3/__https:/...
06.02.2026 07:56 โ ๐ 33 ๐ 14 ๐ฌ 1 ๐ 1
Lovely lab hike in Werribee Gorge to celebrate the EckMasLabโs 5th birthday ๐
05.02.2026 21:30 โ ๐ 12 ๐ 1 ๐ฌ 0 ๐ 1
A Triumvirate of Transformation: Oncogene, Ontogeny, and Plasticity
Summary:. Cancer cells display extensive heterogeneity that influences therapy response and clinical outcome, yet the underlying mechanisms remain incompletely understood. Recent studies reveal that t...
New Spotlight in @aacrjournals.bsky.social
#Oncogene ร #Ontogeny ร #Plasticity shape leukemia biology & therapy response.
Two complementary studies show: mutations alone donโt explain disease behaviorโdevelopmental state and cellular plasticity matter.
aacrjournals.org/bloodcancerd...
๐ฉธ๐งฌ
EpiSci
04.02.2026 18:28 โ ๐ 7 ๐ 4 ๐ฌ 1 ๐ 0
Institut Pasteur (@pasteur.fr) is recruiting new young PIs to open new groups in the Institute. Deadline is February 9th! Don't miss the opportunity!
27.01.2026 18:56 โ ๐ 34 ๐ 49 ๐ฌ 0 ๐ 0
SS18::SSX activates Polycomb target genes without BAF โ
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
โก๏ธ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma ๐ฏ
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
28.01.2026 10:20 โ ๐ 22 ๐ 16 ๐ฌ 3 ๐ 0
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity
Synovial sarcoma is driven by the SS18-SSX fusion oncoprotein, which has been assumed to promote tumorigenesis through its incorporation into the SWI/SNF chromatin remodeling complexes. Accordingly, therapeutic efforts have focused on targeting SS18-SSX containing SWI/SNF assemblies, yet these approaches have produced limited clinical benefit. Here, we demonstrate that SS18-SSX sustains oncogenic transcription independent of SWI/SNF activity. Despite efficient degradation and dismantling of SWI/SNF complexes, fusion occupancy at target loci and associated gene expression programs remain largely intact. Instead, we identify the acetyltransferase P300 as an essential co-factor supporting SS18-SSX chromatin binding and transcriptional activation. Targeting P300 displaces the fusion from chromatin, suppresses its transcriptional output, compromising synovial sarcoma viability. Notably, dual PROTAC mediated degradation of P300 and SWI/SNF produces strong synergistic effects, broadly disrupting SS18-SSX localization and function. These findings redefine the mechanistic basis of synovial sarcoma and reveal a mechanistically anchored therapeutic strategy for targeting its core oncogenic driver. ### Competing Interest Statement C.R.V. has been a consultant for Flare Therapeutics, Roivant Sciences and C4 Therapeutics; has served on the advisory boards of KSQ Therapeutics, Syros Pharmaceuticals and Treeline Biosciences; has received research funding from Boehringer Ingelheim and Treeline Biosciences; and owns stock in Treeline Biosciences. S.A.A. has been a consultant and/or shareholder for Neomorph, Imago Biosciences, Hyku Therapeutics, C4 Therapeutics, Accent Therapeutics and Nimbus Therapeutics; and has received research support from Janssen and Syndax. N.O.C. is a co-founder, shareholder and management consultant for PhenoTherapeutics Ltd; and a shareholder in Amplia Therapeutics Ltd All other authors declare no financial interests UKRI, EP/X039633/1 Worldwide Cancer Research, https://ror.org/031tfbz57, 21-0271 Science Foundation Ireland, https://ror.org/0271asj38, 18/SIRG/5573
Synovial sarcoma is driven almost exclusively by a single oncofusion โ SS18-SSX
For years, the assumptions on disease mechanisms were simple:
โก๏ธ SS18-SSX works by hijacking SWI/SNF chromatin remodeling activity
Our new study shows that assumption was wrong ๐งต๐
www.biorxiv.org/content/10.6...
28.01.2026 09:54 โ ๐ 24 ๐ 10 ๐ฌ 2 ๐ 2
#FragileNuclesome is back tomorrow! Join us to hear about exciting talks from:
- @au-ho-yu.bsky.social in @robklose.bsky.social's group about transcriptional control by SET1/MLL complexes
- @gcloner.bsky.social at @epicypher.bsky.social about the histone PTM landscape of the immune system
27.01.2026 18:24 โ ๐ 9 ๐ 5 ๐ฌ 0 ๐ 0
Great to catch up with alumni @nchoy.bsky.social who stopped by to visit the lab. So great to hear about your internship adventures with @robertife.bsky.social and see you doing so well!
23.01.2026 07:00 โ ๐ 8 ๐ 1 ๐ฌ 0 ๐ 0
Medical Research Matters
Right now, the Government is starving medical research of full funding, even as it claims that science and research are national priorities. If our leaders truly value science as much as they say, then they must back their words with actionโand fund it properly.
Join the campaign!
23.01.2026 05:23 โ ๐ 96 ๐ 43 ๐ฌ 4 ๐ 6
Humbled to have recieved NHMRC funding to understand molecular underpinnings of breast cancer plasticity.
Sadly, the bleak 8% success means many deserving applications went unfunded. Australia is missing out on scientific discoveries and all the direct and indirect benefits this brings our society.
14.01.2026 07:46 โ ๐ 10 ๐ 0 ๐ฌ 1 ๐ 0
๐ ASSCR Call for Reviewers (2026)
PhD-qualified members are invited to join the Abstract & Awards reviewer panel.
๐๏ธ Commitment AugโNov | ~20โ30 abstracts
๐
Apply by 12 Jan 2026
๐ docs.google.com/forms/d/e/1F...
#ASSCR #StemCells
06.01.2026 03:00 โ ๐ 0 ๐ 1 ๐ฌ 0 ๐ 0
Most researchers miss out on innovation grants while medical fund sits on $25b
Nine in 10 Australian researchers had their โideas grantโ applications rejected last year, even as Australiaโs medical investment fund sits on $5 billion more than it was designed to hold.
The government canโt claim that medical research is a priority while failing to treat it as one. Nine in 10 leading researchers in Australia are missing out on government support for worldโclass proposals, leaving exceptional talent uncertain about their future.
03.01.2026 23:32 โ ๐ 108 ๐ 48 ๐ฌ 2 ๐ 2
Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
30.12.2025 15:02 โ ๐ 184 ๐ 50 ๐ฌ 13 ๐ 14
Celebrating a wonderful end to 2025! Wishing everyone a happy festive season and happy new year
16.12.2025 09:35 โ ๐ 15 ๐ 1 ๐ฌ 0 ๐ 0
Australiaโs medical and scientific research sectors save lives and are vital to our economy. The government has to step up and lean in to their potential.
Itโs small-minded and short-sighted to force them to wither on the vine, when we have money put aside for this purpose in the Future Fund.
07.12.2025 22:25 โ ๐ 48 ๐ 20 ๐ฌ 2 ๐ 0
Half the Funding. Half the Future. - AAMRI
The Medical Research Future Fund (MRFF) was designed to deliver $1 billion each year in new, lifesaving funding for medical research. We know through financial modelling that the full amount can be re...
The Medical Research Future Fund (MRFF) funds medical research in Australia. Only half the funds have been released. If you're an Australian and able to vote please use the form below to email your local MP to release the full amount of the MRFF
aamri.org.au/mrff/
16.11.2025 21:14 โ ๐ 7 ๐ 7 ๐ฌ 0 ๐ 0
Great first day of stem cell science on the beach at #ASSCR2025! Here is our @asscr.bsky.social president opening the conference. Highlights include keynote from @josh-brickman.bsky.social and presentation of @ausstemcell.bsky.social 2025 Metcalf awards. Congratulations to the worthy recipients!
10.11.2025 08:54 โ ๐ 5 ๐ 2 ๐ฌ 0 ๐ 0
Speakers โ Lorne Genome
No description found
Last chance! Early bird rates and oral presentation abstract submissions for Lorne Genome ๐๐ง๐ ๐๐จ๐ฏ๐๐ฆ๐๐๐ซ ๐๐ญ๐ก, ๐๐๐๐ - only one week away: https://www.lornegenome.org/registrations
We have a fantastic lineup of national and international speakers: https://www.lornegenome.org/speakers. Join us!
30.10.2025 21:30 โ ๐ 6 ๐ 6 ๐ฌ 0 ๐ 0
๐ Congrats to Prof Caroline Gargett, recipient of the 2025 #ASSCR Presidentโs Award! ๐
A pioneer in endometrial stem/progenitor cell research, her work continues to shape womenโs health & inspire our field. ๐งฌโจ
#StemCells #Leadership #ScientificExcellence
21.10.2025 02:57 โ ๐ 2 ๐ 1 ๐ฌ 0 ๐ 1
Congratulations to the winners of the 2025 AEpiA Emma Whitelaw Publication Award!
๐งฌ 1st place: @shellainasci.bsky.social
๐งฌ 2nd place: @victoriasugrue.bsky.social
๐งฌ 3rd place: @dairegannon.bsky.social
This award recognises outstanding publications by ECRs in the field of epigenetics.
20.10.2025 06:16 โ ๐ 13 ๐ 4 ๐ฌ 1 ๐ 1
Very much looking forward to this new โspin-outโ from Australiaโs highly successful Stem Cell Conversations - this new series focuses on research career and development. Join us for the first Stem Cell Transitions! It will only take 30min out of your dayโฆ
@asscr.bsky.social
19.10.2025 22:17 โ ๐ 6 ๐ 0 ๐ฌ 0 ๐ 0
Saddened to hear of the passing of one of my scientific heros who has inspired me, as Iโm sure so many others, throughout my career. My thoughts are with his family and friends
08.10.2025 09:40 โ ๐ 5 ๐ 0 ๐ฌ 0 ๐ 0
Melbourne Epigenetics club on today! Two fabulous speakers followed by a catered networking reception. If youโre in Melbourne please drop by!
06.10.2025 21:43 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
#Jobalert ๐จ: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...
22.09.2025 14:22 โ ๐ 14 ๐ 19 ๐ฌ 0 ๐ 0
Computational Biologist in the Narita Lab, CRUK CI and CRA at Homerton College, University of Cambridge. ๐ฉท ๐๐โโฌ๐งถ๐งฎ๐ป๐งฌ๐งช๐งซ๐ญ
noun | a reference source containing words alphabetically arranged along with information about their forms, pronunciations, functions, and etymologies
Childhood Cancer | Chromatin Biology | Therapeutics | Outdoor Adventures
https://www.brienlab.com/
Associate Member in csBio at Memorial Sloan Kettering. Perturb-seq, single-cell functional genomics, and techniques for perturbing the genome.
The European Association for Cancer Research has 14,000+ members. Our aim? Advancing cancer research ๐ฅผ๐ฌ๐ #KeepResearchCurious
www.eacr.org
A project of The Center For Scientific Integrity https://centerforscientificintegrity.org/
Daily newsletter http://eepurl.com/bNRlUn
Database http://retractiondatabase.org
Tips team@retractionwatch.com (better than @ replies)
The preeminent Australian conference on the organisation and expression of the genome
Group leader at @cbgpmadrid.bsky.social working on #epigenetics and #genomics in Arabidopsis and Brassica crops. Tweets science & related stuff in english and espaรฑol.
Scientist/PI Hubrecht Institute. Exploring gene regulation in early development and cancer. Single-cell spatial genome organization & epigenomics
Computational & Genomics Lab studying 3D genome function and dynamics @ Netherlands Cancer Institute
Chromatin Systems Biology
Assistant Professor at Center for Molecular Medicine - UMC Utrecht
Functional Genomics, Rare Diseases and Cardiovascular Disease @ Exeter University
ORCID 0000-0001-8074-6299
The Kwan lab at Univ of Michigan studies neural circuit development, chromatin regulation, & brain disorders using genetics & genomics.
kwanlab.org
Professor at the Australian National University. Biosecurity, fungal and plant genomics, evolution, and biochemistry. Dad. Swimming, reading, nature.
PhD Student at Iovino Lab, Max Planck Institute of Immunobiology and Epigenetics.
๐จ๐ด #EvoDevo PostDoc in the constant *Job-Hunting in EU*
Single-cell-omics & other-omics
Opinions are only my own
#embryo2019
Github: dasalam42
Mastodon: @drsalamander@genomic.social
Twitter: @DrSalamander
https://evobioseries.com/#episode-14
New PI @mpi_ie, interested epigenetics, development, homologous chromosome interactions and their function (she/her)
