Our beloved and long-serving @mrclmb.bsky.social PNAC Divisional Administrator Michele Hare has retired. We gathered to wish her well and a long, happy and music-filled retirement.
23.01.2026 18:42 — 👍 7 🔁 1 💬 0 📌 0
YouTube video by MRC Laboratory of Molecular Biology
Through the doors of discovery - an introduction to the MRC Laboratory of Molecular Biology
To complement the launch of our new LMB website, we’ve shared a new introductory video on our YouTube channel.
Meet some of our scientists and support staff, take a look around our wonderful building and see how we come together to unravel how life works.
youtu.be/JmC17_4bEMA?...
23.01.2026 15:28 — 👍 6 🔁 4 💬 1 📌 0
🌐Our new LMB website is live!🌐
Fresh design, better navigation, same first-class science.
Take a look around ➡️ mrclmb.ac.uk
19.01.2026 17:25 — 👍 21 🔁 11 💬 1 📌 1
An AI Researcher in the Cathedral of Molecular Biology
How we designed catalytic RNA functions, and what I learned holding a pipette at the MRC Laboratory of Molecular Biology.
I wrote some personal reflections about being physically embedded in a world-leading molecular biology lab @mrclmb.bsky.social, learning to communicate with experimentalists, back-breaking wet lab work, scientific rigour, and skin in the game!
💌: chaitjo.substack.com/p/an-ai-rese...
18.12.2025 15:38 — 👍 4 🔁 1 💬 0 📌 0
Excited to release the fully open-source code for gRNAde - our wet-lab validated, generative AI framework for 3D RNA inverse design 🚀⭐️
I pride myself on open-science & this is probably the most intense release I've done!
15.12.2025 09:25 — 👍 8 🔁 2 💬 1 📌 0
Pre-pore and cis pores formed by full length perforin-2 during antigen escape from early phagosomes
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
11.12.2025 09:21 — 👍 15 🔁 8 💬 0 📌 0
SynHG logo, with letters Syn coloured orange, H represented by an image of a paired chromosome, followed by capital G in black.
New pipeline to implant human chromosomes into mouse cells and back again signals first step in mammoth undertaking to synthesise the human genome.
Read more about the achievement from LMB’s PNAC Division as part of the SynHG project: www2.mrc-lmb.cam.ac.uk/transplant-o...
#LMBResearch
05.12.2025 09:51 — 👍 3 🔁 2 💬 0 📌 0
Check out the latest paper from Leo James and William McEwan which explains the science behind LMB spin out TRIMTECH Therapeutic's TRIMTAC® degraders ⤵️
28.11.2025 14:54 — 👍 3 🔁 2 💬 0 📌 0
Great culture can save lives. Literally.
Amazing letter in today’s @thetimes.com about Tom Stoppard
02.12.2025 08:48 — 👍 11872 🔁 4084 💬 145 📌 447
Congratulations!
03.12.2025 11:46 — 👍 1 🔁 0 💬 0 📌 0
Ana Tufegdžić Vidaković at a lab bench
Congratulations to @anatv.bsky.social, Group Leader in the LMB’s PNAC Division, who has joined @embo.org’s Young Investigator Programme!
Read more about the programme and Ana’s research here: www2.mrc-lmb.cam.ac.uk/ana-tufegdzi...
#LMBNews
02.12.2025 13:05 — 👍 19 🔁 3 💬 1 📌 0
Pilar raises her Asgard bridge from the sea!
02.12.2025 23:08 — 👍 8 🔁 2 💬 1 📌 0
Introducing gRNAde: our own little "AlphaGo Moment" for RNA design! 🧬🚀
📝: tinyurl.com/gRNAde-paper
Unlike proteins, RNA design has long relied on "wisdom of the crowd" (human experts) or the slow crawl of directed evolution — gRNAde changes that! 🧵👇
03.12.2025 06:45 — 👍 28 🔁 6 💬 2 📌 5
YouTube video by Cambridge Biomedical Campus
Welcome to the Cambridge Biomedical Campus
What do apple trees, Nobel Prizes, cows, and world-changing innovation all have in common? Well, they're all part of a new animated journey across one of Europe’s most extraordinary places, the Cambridge Biomedical Campus.
youtu.be/2K7Txdwb_k4
20.10.2025 10:57 — 👍 6 🔁 6 💬 0 📌 1
LMB prize winners with certificates in the Max Perutz Lecture Theatre with clapping audience
Congratulations to the 2025 recipients of the Eileen Southgate Staff Prize which recognises those who have made outstanding contributions to the LMB: Ian Elbrow, Pam Gallacher, Jessica McCool and Alison Turnock.
Read more about their work here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
24.10.2025 08:53 — 👍 10 🔁 3 💬 0 📌 0
LMB prize winners with certificates in the Max Perutz Lecture Theatre with clapping audience
Congratulations to the 2025 recipients of the Perutz Student Prize and the Joan Steitz Postdoc Prize: Claudia De Miguel, @lucaschwarz.bsky.social, Tom Dendooven, Sofia Lövestam, Katerina Naydenva & Tomke Stürner.
Find out why they won here: www2.mrc-lmb.cam.ac.uk/lmb-prizes-2...
#LMBNews 👏
24.10.2025 08:52 — 👍 16 🔁 5 💬 0 📌 1
Glowing E. coli bacteria in green and blues on a background of DNA bases
Rewriting the language of life: Jason Chin’s group in the LMB’s PNAC Division have synthesised E. coli with just 57 codons instead of the usual 64.
Syn57 required 101000+ codon changes & represents a bold step towards programmable life.
Read more: www2.mrc-lmb.cam.ac.uk/syn57-repres...
#LMBResearch🧪
01.08.2025 08:27 — 👍 7 🔁 4 💬 0 📌 1
We are excited to be a part of a collaboration lead by Tarafder and Bharat titled "Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms" - this work has exciting implications for biofilm-targeted therapeutics.
www.biorxiv.org/content/10.1...
29.07.2025 13:08 — 👍 13 🔁 4 💬 1 📌 1
Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
14.07.2025 12:09 — 👍 27 🔁 33 💬 1 📌 4
Excited to be at the MRC Laboratory of Molecular Biology (LMB) for the first time to present at the Life Sciences Students Symposium. Such impressive venue. No pressure!
11.07.2025 13:43 — 👍 3 🔁 1 💬 0 📌 0
Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.
Glad to be featured in the Editors’ Highlights!
www.nature.com/articles/s41...
#splicing #cryoEM
10.07.2025 14:29 — 👍 71 🔁 21 💬 1 📌 0
Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.
11.07.2025 10:22 — 👍 59 🔁 17 💬 1 📌 0
In the paper, we investigate RNA polymerase ribozymes and their ability to perform rolling circle synthesis (RCS).
We previously showed that RCS is possible, though inefficient. Now, we use cryo-EM and identify a network of unexpected structures (see movie) which affect RCS.
(2/4)
18.06.2025 09:41 — 👍 3 🔁 3 💬 0 📌 0
Andy Fire
Stanford University
Cellular response to genetic change
Monday 30th June at 11am (BST)
Interested in how cells respond to genetic change?
Don’t miss this #LMBSeminar from Andy Fire of Stanford University!
Visit our website for more info on how to join: www2.mrc-lmb.cam.ac.uk/news-and-eve...
05.06.2025 15:58 — 👍 4 🔁 2 💬 0 📌 0
Portrait photo of Tanmay Bharat
Congratulations to @tbharat-lab.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has received the Gold Medal from @embo.org for his research on prokaryotic surface molecules.
Read more here: www2.mrc-lmb.cam.ac.uk/tanmay-bhara...
#LMBNews
05.06.2025 12:07 — 👍 61 🔁 12 💬 3 📌 1
Structural biologist interested in human health and disease, working on structure and function of proteins.
https://scholar.google.com/citations?user=EAfSbDcAAAAJ
Cutting-edge research, news, commentary, and visuals from the Science family of journals. https://www.science.org
Research, news, and commentary from Nature, the international science journal. For daily science news, get Nature Briefing: https://go.nature.com/get-Nature-Briefing
physician-scientist, author, editor
https://www.scripps.edu/faculty/topol/
Ground Truths https://erictopol.substack.com
SUPER AGERS https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666
Senior Desk Editor for Life Sciences at Scientific American, covering earth and the environment. (she/her) Posts are entirely my own and not reflective of my employer. Email: andrea.thompson@sciam.com Signal: @AndreaT.95
Chief Editor of Nature Biomedical Engineering. Ph.D. Previously at Nature Methods. @rita_strack on the place formerly known as twitter.
The Milner Therapeutics Institute encompasses both a research institute and a global outreach programme, which aims to transform pioneering science into therapies.
Your trusted specialist life science distributor.
Cell biologist and immunologist.
Group Leader at MRC LMB @mrclmb.bsky.social
🧪 Dendritic cells, antigen presentation, endocytic escape
CDT in BioDesign Engineering PhD student at Imperial College London working on retrons, genome editing and continous evolution in the Jimenez lab; Biochemistry MSci and BA Graduate from University of Cambridge
Immunologist x cell biologist x microbiologist at MRC LMB in Cambridge. Occasionally birdwatching. Less nerdy than my bio sounds. Views my own.
Our group at the LMB in Cambridge is dedicated to uncovering structures and mechanisms of the replisome.
https://www2.mrc-lmb.cam.ac.uk/group-leaders/t-to-z/joseph-yeeles/
A multidisciplinary community of researchers with the mission to better understand the roots of disease and narrow the gap between new biological insights and impact for patients. Broadinstitute.org
🥖😬👨🎨 (France) - 🍯🍷🌧️ (Dijon) - 🧬🔬🧪 (CNRS)
Chemical biology/genetics. Occasional fiction writer in the grant-proposal genre.
Trying to understand why and how DNA and RNA fold into ωєιя∂ℓу ѕнαρє∂ structures.
https://sites.google.com/site/monchaudchembiolab/
Group Leader, MRC Laboratory of Molecular Biology & Joint Head of the Division of Protein & Nucleic Acid Chemistry. Senior Executive Editor, Nucleic Acids Research.
Interdisciplinary organization led by Dr. Steven Benner combining chemistry, synthetic biology & astrobiology, translating basic research into medical and commercial technologies. Visit our website at https://ffame.org/.
Award-Winning Author, Senior Editor at Nature. Recovering Palaeontologist. DISCLAIMER: This is a personal account. Reposts aren’t Endorsements. Views expressed need not reflect the official view of Springer Nature. Glad we've cleared that one up.
Assistant Professor @ Princeton MolBio |
From transposons to telomeres and back | bicycles and biochemistry
https://ghanim.lab.princeton.edu
Science writer and author of books including Bright Earth, The Music Instinct, Beyond Weird, How Life Works.
Reader in Synthetic Biology at Imperial College London #synbio and evolution for health, the environment and the circular economy josejimenezlab.com
