Yttri Lab

two men are sitting in front of a window with blinds . ALT: two men are sitting in front of a window with blinds .

Powerful work by soonish-defending @markolas.bsky.social that contributes to discussions of M1 computations and the role of M1 and striatum in action selection, kinematic tuning.

Even when behavior partially recovered after 10+ days, kinematic tuning in striatum did not. Several lines of evidence point to this being delayed due to remapping in cortex. Reaches were performed but were varied, in line with aberrant striatal activity

What about striatum? @markolas.bsky.social recorded daily for 20 days post lesion and found that although baseline activity was unchanged, no motor-related signals were present for those movements that did occur, either in SPNs nor FSIs.

Following lesions, for the first 8-9 days, mice could not do the task. Also, while they could walk fine-they froze in place for MINUTES when deciding to go left or right or switch their motor pattern to navigate around an easy obstacle (unrewarded).
This also went away over several days.

Motor cortex is responsible for motoric dynamics in striatum and the execution of both skilled and unskilled actions Nicholas and Yttri find that in the absence of motor cortex, the stratum alone is not capable of producing goal-directed behavior. Lesions of motor cortex also produce a freezing of gait-like behavior...

In an effort to bring #neuroskyence to @bsky.app I wanted to share our recent paper in Neuron
tinyurl.com/LesionsOfM1
@markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions
@cmuscience.bsky.social @the-cnbc.bsky.social