ICYMI: At #ESCCongress, new TRANQUILITY data showed pacibekitug delivered consistent hs-CRP reductions across subgroups & effects on multiple IL-6-related biomarkers, reinforcing the potential of pacibekitug to address residual inflammatory risk in CVD. https://bit.ly/3HZE1Z1
12.09.2025 16:45 — 👍 0 🔁 0 💬 0 📌 0
Tourmaline Bio Enters into Agreement to be Acquired by Novartis AG
Transaction reflects the potential of Tourmaline’s pacibekitug, a long-acting, fully-human, anti-IL-6 monoclonal antibody with best-in-class potential, for the treatment of cardiovascular diseases
See our press release at ir.tourmalinebio.com/news for more details
This morning, Tourmaline announced an agreement to be acquired by @novartis.bsky.social. We believe this transaction will accelerate development of pacibekitug, our lead program targeting IL-6, a key driver of inflammation in cardiovascular disease. Read more: bit.ly/45UIbuv #cardiosky #biosky
09.09.2025 11:04 — 👍 1 🔁 0 💬 0 📌 0
New TRANQUILITY data at #ESCCongress 2025 show pacibekitug reduces hs-CRP across subgroups and lowers biomarkers like Lp(a), fibrinogen, and serum amyloid A, reinforcing pacibekitug’s consistent impact on IL-6-related biomarkers.
View poster: https://bit.ly/3HZE1Z1
31.08.2025 19:38 — 👍 0 🔁 0 💬 0 📌 0
We’re heading to #ESCCongress 2025 to share additional data from our ongoing Phase 2 TRANQUILITY trial. Learn more about our approach to tackling residual inflammatory risk in cardiovascular disease: https://bit.ly/3HWWtBs #cardiosky
28.08.2025 16:51 — 👍 0 🔁 0 💬 0 📌 0
More than 35 million people globally live with abdominal aortic #aneurysm (AAA). Yet there are no FDA-approved medicines to slow or stop its progression. The current treatment paradigm does not address the underlying biology of the disease.
Learn more: bit.ly/4m2Bc8h #Cardiosky #biosky
26.08.2025 13:34 — 👍 0 🔁 0 💬 0 📌 0
A new paper in Circulation: Genomic and Precision Medicine explores IL-6 signaling as a case study in drug development informed by human genetics, offering a roadmap for advancing precision therapies in ASCVD. #Cardiosky #biosky
Read more: bit.ly/3J3oXd7
19.08.2025 18:52 — 👍 1 🔁 1 💬 0 📌 0
Today, we announced our financial results for the second quarter of 2025 and recent business highlights. See our progress and preview what’s to come in the second half of 2025: bit.ly/45fsVrL
13.08.2025 11:16 — 👍 0 🔁 0 💬 0 📌 0
AAA isn’t just a structural issue; it’s an inflammatory disease. Research shows chronic #inflammation drives damage to the aortic wall, contributing to #aneurysm growth and rupture.
Targeting inflammation could offer a new way forward. Learn more: bit.ly/4m2Bc8h #biosky
07.08.2025 16:30 — 👍 0 🔁 0 💬 0 📌 0
We’re proud to feature Famina Hemani, PharmD, as this quarter’s Employee Spotlight. As VP, Head of Pharmacovigilance, she brings deep expertise and a patient-first commitment to our team, ensuring safety remains central as we work to advance meaningful therapies.
28.07.2025 14:34 — 👍 0 🔁 0 💬 0 📌 0
Often called a “ticking time bomb,” abdominal aortic #aneurysm (AAA) is a silent but serious threat. If undetected, an AAA can grow unnoticed until it ruptures- a frequently fatal event.
Despite this, treatment options remain limited. Learn more: bit.ly/3TXwnRr #Cardiosky #biosky
24.07.2025 14:33 — 👍 0 🔁 0 💬 0 📌 0
Tourmaline CEO, Sandeep Kulkarni and CFO, Ryan Robinson participated in Leerink Partners’ I&I and Metabolism Forum to discuss IL-6’s role in disease progression and the need for continued innovation in immune and inflammatory diseases.
Learn more: bit.ly/4eHaYWe #biosky
09.07.2025 18:51 — 👍 0 🔁 0 💬 0 📌 0
The Tourmaline Bio team at the NASDAQ belling ringing for becoming a publicly-listed biotech company.
👋Join us on the journey.
We’re a clinical-stage biotech exploring IL-6 biology to treat immune & inflammatory diseases, including atherosclerotic cardiovascular disease (ASCVD), thyroid eye disease (TED), & abdominal aortic aneurysm (AAA). $TRML
Meet Tourmaline Bio:
#Cardiosky #EndoSky #Ophthosky
23.06.2025 16:03 — 👍 1 🔁 0 💬 0 📌 0
From the experience of @stitches.today, we bring you the best papers in medicine, daily in your inbox - for free!
Subscribe 👉 www.stitches.today/medicine
Science journalist and correspondent for Nature (she/her). Reach me at alexwitze.01 (Signal), witzescience (@gmail.com), or awitze (@protonmail.com).
Features editor, Nature. E: r⟦dot⟧vannoorden⟦at⟧nature⟦dot⟧com or richardvannoorden⟦at⟧protonmail⟦dot⟧com. Signal: richvn.01 . (Currently on parental leave, to April 2026).
Editor in Chief of Nature, geneticist, editor, accidental potter. All views my own
Chief Biological, Clinical and Social Sciences Editor of Nature
Any views expressed here are my own
Deputy Editor at Nature, Cancer, Biomedicine, Genetics and Biotechnology. All views my own.
senior editor at Nature for cellular & mitochondrial metabolism, metabolic physiology, cardiology, vascular biology, clinical science. All views my own.
nerdy | queer | they/m
Senior Editor @Nature for cancer and cell cycle. Views my own
Editor @ Nature‘s Bio team (nature.com @nature.com) - struct bio, RNA, membrane transport, ribosomes, biophysics, proteomics, synth bio, … - located in Berlin. He/him. Opinions are my own.
I'm Nature's Deputy Editor for ecology, evolution and social science and handle papers in cog neuro, psych, and a variety of behavioral and social sciences. When I'm not working, I'm a mom (and sometimes even try to find time to play my harp or ski).
Snr. Ed. @Nature, author ‘The Decline & Fall of the Human Empire', ‘A (Very) Short History of Life on Earth'. Pronouns he/him/his. Adjectives dopey/sleepy/grumpy. Reposts don't imply approval. Views own. Black belt in Tsundoku. Rock god. Dog person.
I write the Nature Briefing, a daily email for Nature (@nature.com) about all the science, which I hope you will enjoy.
Senior editor at Nature, handling the micro stuff, including bacterial and fungal pathogens, host-associated microbiomes, host-microbiota interactions, phage-bacteria interactions, antimicrobial discovery and AMR, among many others...
All views my own
Astronomy & Astrophysics Editor at Nature, very invested in better life on Earth. Views my own.
Editor at Nature. Handling AI, computing & robotics. views my own
Chief Editor of Audience and Engagment at Nature. Twin mum, Irish, big fan of tea
Social media @nature.com. Has been known to enjoy a showtune. Scottish. She/her. Views are very much my own.
News featured editor at Nature. bmaher.01 on signal.
Climate science editor for @nature.com, handling submissions on atmospheric science, oceanography, the cryosphere, and hydrology. Podcast archive at https://forecastpod.org/.