Come join us in person for an AI workshop watch party.

Come work with us in this vibrant and diverse department csb.utoronto.ca

The Department of Cell & Systems Biology at University of Toronto invites applications for a full-time tenure stream position in the field of Animal Morphogenesis.
#CellBiology #DevelopmentalBiology #mechanobiology #TissueMorphogenesis
#SystemsBiology

jobs.utoronto.ca/job/Toronto-...

CEEHRC 11th Annual Canadian Conference on Epigenetics Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

CALL FOR ABSTRACTS!

The deadline for abstract submission (for talk consideration), early-bird rates, and travel award applications for the 2025 CEEHRC Annual Meeting is TODAY, FRIDAY, SEPTEMBER 19!

event.fourwaves.com/...

#epigenetics #ceehrc #epigenomes
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DEADLINE EXTENDED!

Early-bird registration, abstract submission for talk consideration, and travel award application deadline has been extended to FRIDAY, SEPTEMBER 19!

Abstracts submitted after Sep 19 will be included in poster sessions.

event.fourwaves.com/...
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Come join us in person for an AI workshop watch party.

Job add showing the lab logo and the following text: WHAT WE OFFER Fully-funded fellowships up to five years Opportunity to start your own research program or lead ongoing projects. Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville. WHO YOU ARE You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

Fragile Nucleosome Fall Seminars: September 10 Grace Bower, Kvon Lab @ UC Irvine, USA Jennifer Phillips-Cremins, UPenn, USA September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA Juanma Schvartzman, Columbia University, USA October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA Alex Federation, Talus Bio, USA October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland Seungsoo Kim, UC Irvine, USA November 5 Hannah Long, University of Edinburgh, UK Jeff Vierstra, Altius Institute, USA November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada Sarah Teichmann, University of Cambridge, UK December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain Jonathan Henninger, Carnegie Mellon, USA December 17 Rebecca Berrens, Oxford University, UK Jean-Benoit Lalanne, University of Montreal, Canada

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

Enhancers mediate euchromatin hopping at chromatin contact points Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...

Our latest is online now, we discovered that enhancers cause surrounding chromatin to acquire euchromatin modifications and produce non-coding RNA making regions without enhancer activity look like enhancers. doi.org/10.1101/2025...

Researchers identify protein that evolved to enable plants to thrive on land Evolutionary plant biologists at the University of Toronto have identified a protein that evolved approximately 500 million years ago that enables plants to convert light into energy through photosynt...

🧪🌱Plants started off as aquatic organisms. But how did they make the jump to land?
The Christendat lab show in @molbioevol.bsky.social that SKL1 is necessary for chloroplast formation and this function is conserved in land plants from liverworts to flowering plants!
www.utoronto.ca/news/researc...

#DYK there is #SciArt on display around the CSB Buildings @utoronto.ca?
Keep your eyes open for gorgeous images created by our @uoftartsci.bsky.social students, from their research and as artwork
You can also view these images in our online gallery!
csb.utoronto.ca/research-ove...

CEEHRC 11th Annual Canadian Conference on Epigenetics Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

The CEEHRC Annual Meeting returns this fall!

Register NOW for the 11th Canadian Conference on Epigenetics taking place November 12-15, 2025 at the Banff Centre for Arts and Creativity in Banff, Alberta.

event.fourwaves.com/...
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Welcome Felix, we’re thrilled to have you join CSB@UofT

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium Author summary The muscular layer of the uterus, is responsible for the forceful contractions that deliver the baby at the end of pregnancy. During the majority of pregnancy this muscle is not able to...

Our study of how the AP1 transcription factor JUND regulates gene expression during human pregnancy is out now in @PLOS Genetics can01.safelinks.protection.outlook.com?url=https%3A...

It’s a pun-tastic research day @uoftcellsysbiol.bsky.social

b2B speed networking event: connecting CSB students and alumni through shared experiences and snacks - Department of Cell & Systems Biology CSB students networked with alumni during a recent speed mentorship reception. Along with specific career advice, students learned a few common themes for the modern job market

CSB students from @uoftartsci.bsky.social networked with alumni during a recent Backpack to Briefcase speed mentorship reception with @uoftalumni.bsky.social. Check out the story for career tips and examples of potential career paths!

Access alone is not enough; people need high-quality care.

Fewer women are dying in childbirth as access to health care has increased.

Maternity service coverage has increased.

Access to health care saves lives. Pregnancy can be a dangerous time in a woman's life.

It's #WorldHealthDay
Since 2000, maternal deaths globally declined by 40%! 💙

BUT—progress is slowing, and aid funding cuts mean major threats to lifesaving maternity services in many parts of the world. ❌

Image shows Melanie Woodin

Melanie Woodin, an internationally recognized neuroscientist who studies the mechanisms underlying learning and memory in the brain, has been named #UofT’s 17th president. ➡️ uoft.me/uoftpres

As you scroll through our skeets, you’ll see that women scientists are vital to discoveries made at CSB.
For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience
csb.utoronto.ca/supporting-t...

Supporting the talented women scientists of CSB on IDWGS csb.utoronto.ca/supporting-t...

This was a big collaborative effort started by Sakthi D Moorthy, now at CCRM, and brought to the finish by @itobiaslab.bsky.social now at @uofguelph.bsky.social
Thank you to all the team and to CIHR for funding our efforts to understand gene expression regulation in the brain!

The cells missing SRR2-18 shift their transcriptome and accessible chromatin away from the developing forebrain to a state more similar to the neural tube.

Deleting the Sox2 SRR2-18 enhancer cluster on both alleles causes a loss of neural stem cell self renewal at higher passages.

A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells Abstract. Sex-determining region Y box 2 (Sox2) is a critical transcription factor for embryogenesis and neural stem and progenitor cell (NSPC) maintenance

Our work on the enhancers regulating Sox2 in neural stem cells is published! This one has been a long time in the works. We found a cluster of downstream enhancers, including the more well studied SRR2, are required to maintain Sox2 expression and anterior neural identity.
doi.org/10.1093/g3jo...

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

Career achievement unlocked - two publications come out on the same day!

Great collaboration with Tom Sexton
doi.org/10.1126/scia...

And fantastic work by Tiegh Taylor and Mitchell lab colleagues
journals.plos.org/plosgenetics...

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

Out now in @ScienceAdvances A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin
doi.org/10.1126/scia...

The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells Author summary Our study explores how two closely related genes, Lefty1 and Lefty2, are regulated independently despite their proximity in the genome. Both genes play important roles in stem cell main...

The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells. How are 2 genes separately regulated even though they are fairly close to each other in the genome, we find a primary role for gene separation distance. journals.plos.org/plosgenetics...

The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells Author summary Our study explores how two closely related genes, Lefty1 and Lefty2, are regulated independently despite their proximity in the genome. Both genes play important roles in stem cell main...

journals.plos.org/plosgenetics...

Beautiful walk at #AsilomarChromatin this afternoon. Looking forward to the evening session.

Always been amazed how cells actually INTENTIONALLY cause double strand breaks. At @asilomarchroma last night, Cheyenne Sadeghi @FrockLab @Stanford showed evidence supporting that during #meiosis, #ATM kinase can suppress translocations after #SPO11 induces the meiotic double strand break.